Skincare Boutique & Facial Institute
Skincare Boutique & Facial Institute
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Explore La Crem rewardsPersistent dark spots and uneven-looking tone
Two complementary steps: Intensive is the short-contact dark-spot cream you rinse off; Ageless is the daily leave-on care that follows.
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For delivery in Canada: Standard is $25 CAD below $149 CAD. Priority is $30 CAD below $249 CAD and free from $249 CAD on eligible orders. Adding an item excluded from free Priority removes free Priority for the entire order.
This selected item excludes the entire order from free Priority shipping in Canada. Standard is $25 CAD below $149 CAD and free from $149 CAD. A paid Priority upgrade is $30 CAD where available, including orders of $249 CAD or more.
Thresholds apply after discounts, before taxes and shipping. Product, ground-shipping and destination restrictions may apply. Available services and final charges appear at checkout.
Selected with care.
Cyspera
Your ritual begins with the right choice.
$355.00 CAD
Taxes calculated at checkout.
The skincare focus
Two complementary steps: Intensive is the short-contact dark-spot cream you rinse off; Ageless is the daily leave-on care that follows.
Explore our ingredient glossaryCyspera
The ingredients behind this formula—and what they bring to your skin.
Cysteamine 7% in Intensive
the targeted short-contact ingredient for uneven-looking pigmentation.
Isobionic-Amide™
part of the current Cyspera formulas.
Panthenol and squalane in Ageless
support hydration and a comfortable skin feel.
Ingredient imagery is illustrative. Explore the full ingredient list below.
Made to work together
Explore another step in your face-care routine.
Your routine
Prep your skin with the best daily moisturizer that delivers light, soothing hydration with a refreshing citrus scent. This natural moisturizer for dry skin features jojoba seed oil, lemon oil, and hyaluronic acid to hydrate your skin and help support the skin's barrier.
Your routine
The cleansing step and the first step of your Biologique Recherche routine, removing makeup, sunscreen and impurities before your Lotion P50.
Worth knowing
A closer look at your skin, your routine and what goes into the formula.
The Intensive Duo brings together targeted dark-spot care and daily comfort. Intensive combines 7% cysteamine with Isobionic-Amide™ to help soften the appearance of persistent dark spots. Ageless follows on clean, dry skin to support hydration and a smoother-looking complexion.
The routine is easy to remember: apply Intensive, wait for the recommended contact time, cleanse, then apply Ageless. Daily sunscreen is the final morning step.
Give the routine time: Intensive is used daily for 16 weeks, then twice weekly for maintenance; Ageless is used daily. The published before-and-after cases show the original three-step Intensive System with Boost, not this current two-product Duo.
Persistent dark spots and uneven-looking tone
Cyspera Intensive
Aqua/Water, Cysteamine HCl, Isobionic-Amide, Paraffinum Liquidum/Mineral Oil, Glycolic Acid, Potassium Cetyl Phosphate, Glycerin, Isopropyl Myristate, Cetyl Alcohol, Sodium Ascorbyl Phosphate, Arachidyl Alcohol, Butyrospermum Parkii (Shea Butter), Ascorbyl Palmitate, Xanthan Gum, Behenyl Alcohol, Propylheptyl Caprylate, Octyldodecanol, Ethylhexylglycerin, Parfum/Fragrance, Arachidyl Glucoside, Tocopherol, Helianthus Annuus (Sunflower) Seed Oil, Disodium EDTA, Acetyl Cedrene, Amyl Salicylate, Tetramethyl Acetyloctahydronaphthalenes.
Cyspera Ageless
Aqua/Water, Glycerin, Isobionic-Amide, Octyldodecanol, Cetyl Alcohol, Panthenol, Butyrospermum Parkii (Shea) Butter, Hordeum Vulgare (Barley) Seed Flour, Potassium Cetyl Phosphate, Propylheptyl Caprylate, Behenyl Alcohol, Squalane, Xylitylglucoside, Paraffinum Liquidum/Mineral Oil, Ascorbyl Palmitate, Sodium Ascorbyl Phosphate, Phenoxyethanol, Glycine Soja (Soybean) Oil, Ethylhexylglycerin, Anhydroxylitol, Tetrasodium Glutamate Diacetate, Tocopherol, Xanthan Gum, Xylitol, Helianthus Annuus (Sunflower) Seed Oil, Retinol, Tasmannia Lanceolata Fruit/Leaf Extract.
Cyspera Intensive and Cyspera Ageless. Neutralize is a separate complimentary gift during the qualifying offer, subject to gift availability.
Yes. One Intensive Duo qualifies for one Neutralize 50 ml, expiry May 2027, while gift stock lasts. One gift per order; other product or order discounts cannot be combined.
Complete the 16-week daily Intensive phase and compare photos every four weeks in the same lighting. Individual progress varies.
No. The published cases used Intensive, Neutralize and the earlier Boost formula. The current Duo pairs Intensive with Ageless; those cases are context, not a guarantee for this exact combination.
For delivery and return information, view our policy.
The Intensive Duo brings together targeted dark-spot care and daily comfort. Intensive combines 7% cysteamine with Isobionic-Amide™ to help soften the appearance of persistent dark spots. Ageless follows on clean, dry skin to support hydration and a smoother-looking complexion.
The routine is easy to remember: apply Intensive, wait for the recommended contact time, cleanse, then apply Ageless. Daily sunscreen is the final morning step.
Give the routine time: Intensive is used daily for 16 weeks, then twice weekly for maintenance; Ageless is used daily. The published before-and-after cases show the original three-step Intensive System with Boost, not this current two-product Duo.
1. Apply a thin layer of Intensive to dry, unwashed skin. After cleansing, wait at least one hour.
2. Start at 5 minutes and increase gradually to a maximum of 15 minutes as tolerated.
3. Cleanse and pat dry. With Neutralize, massage two pumps directly over Intensive, then rinse.
4. Apply a thin layer of Ageless and leave on.
Use Intensive daily for 16 weeks, then twice weekly; use Ageless daily. Apply broad-spectrum SPF 30 or higher every morning.
Cyspera Intensive
Aqua/Water, Cysteamine HCl, Isobionic-Amide, Paraffinum Liquidum/Mineral Oil, Glycolic Acid, Potassium Cetyl Phosphate, Glycerin, Isopropyl Myristate, Cetyl Alcohol, Sodium Ascorbyl Phosphate, Arachidyl Alcohol, Butyrospermum Parkii (Shea Butter), Ascorbyl Palmitate, Xanthan Gum, Behenyl Alcohol, Propylheptyl Caprylate, Octyldodecanol, Ethylhexylglycerin, Parfum/Fragrance, Arachidyl Glucoside, Tocopherol, Helianthus Annuus (Sunflower) Seed Oil, Disodium EDTA, Acetyl Cedrene, Amyl Salicylate, Tetramethyl Acetyloctahydronaphthalenes.
Cyspera Ageless
Aqua/Water, Glycerin, Isobionic-Amide, Octyldodecanol, Cetyl Alcohol, Panthenol, Butyrospermum Parkii (Shea) Butter, Hordeum Vulgare (Barley) Seed Flour, Potassium Cetyl Phosphate, Propylheptyl Caprylate, Behenyl Alcohol, Squalane, Xylitylglucoside, Paraffinum Liquidum/Mineral Oil, Ascorbyl Palmitate, Sodium Ascorbyl Phosphate, Phenoxyethanol, Glycine Soja (Soybean) Oil, Ethylhexylglycerin, Anhydroxylitol, Tetrasodium Glutamate Diacetate, Tocopherol, Xanthan Gum, Xylitol, Helianthus Annuus (Sunflower) Seed Oil, Retinol, Tasmannia Lanceolata Fruit/Leaf Extract.
The ingredient list on your packaging is the reference.
What is included in the Duo?
Cyspera Intensive and Cyspera Ageless. Neutralize is a separate complimentary gift during the qualifying offer, subject to gift availability.
Does one Duo qualify for the Neutralize gift?
Yes. One Intensive Duo qualifies for one Neutralize 50 ml, expiry May 2027, while gift stock lasts. One gift per order; other product or order discounts cannot be combined.
When should I assess progress?
Complete the 16-week daily Intensive phase and compare photos every four weeks in the same lighting. Individual progress varies.
Is the Duo the same as the original Intensive System?
No. The published cases used Intensive, Neutralize and the earlier Boost formula. The current Duo pairs Intensive with Ageless; those cases are context, not a guarantee for this exact combination.
Ageless contains retinol. Follow each product’s packaging and do not exceed Intensive’s recommended contact time. Avoid eyes, mucous membranes and irritated skin. Ask our team before combining with strong exfoliants or other retinoids. Use daily sun protection.
Published Cyspera case photographs, with the original Day 0, Day 28 and Day 84 labels. View the change in uneven-looking tone across each series.
Individual results vary. These images are shown as published by Cyspera distributor Medevo. The exact formulation and full regimen are not identified for these panels; they do not show results for the current Intensive Duo or for a single product used alone.
View the published Cyspera cases and source information.
The care behind your order
A few helpful details, before your next delivery.
Track your orderDelivery
For delivery in Canada: Standard is $25 CAD below $149 CAD. Priority is $30 CAD below $249 CAD and free from $249 CAD on eligible orders. Adding an item excluded from free Priority removes free Priority for the entire order.
This selected item excludes the entire order from free Priority shipping in Canada. Standard is $25 CAD below $149 CAD and free from $149 CAD. A paid Priority upgrade is $30 CAD where available, including orders of $249 CAD or more.
Thresholds apply after discounts, before taxes and shipping. Product, ground-shipping and destination restrictions may apply. Available services and final charges appear at checkout.
CAD · After discounts, before taxes and shipping. Conditions and product exclusions apply.
Canada & U.S. delivery details02 · Close to home
Choose pickup at checkout when available. We’ll let you know when your order is ready.
Speak with our boutique03 · Care you can count on
Request an eligible return within 30 days. Items must be unopened, unused and in their original packaging. Final-sale exclusions apply.
Returns & order support
the targeted short-contact ingredient for uneven-looking pigmentation.
part of the current Cyspera formulas.
support hydration and a comfortable skin feel.
consider other retinoids in your routine.
Curious about your ingredients?
Explore La Matière
Expert guidance. A considered routine.
Beautiful formulas are only part of the story. Knowing what belongs in your routine makes all the difference.
Talk through your skin, the products you already use and the questions on your mind with one of our facialists.
Book a consultation Just a product question? Ask us.The care behind your care
From your first question to your next replenishment, there’s a real person here to help.
You don’t need to start over. Bring us your current routine and we’ll help you understand where a new formula fits.
Ask our teamTake our skin questionnaire for a thoughtful starting point, then speak with us if you’d like to explore your recommendations.
Find your starting pointA question about how to use it? Unsure about your next step? You’re welcome to come back to our team for guidance.
We’re here to helpFrom our Edmonton boutique
Discover Cyspera Intensive Duo at Loshen & Crem, a skin-health boutique and facial studio in Edmonton, Alberta. Explore the Cyspera collection online across Canada, or speak with our facialists about how this formula fits into the products you already use.
Care, to keep.
The guidance you’ll want when you get home: how to use it, what to expect and when to check in. Your reminder, with your team still in reach.
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