Your routine
iS ClinicalSheald Recovery Balm
Why it fits
A rich moisturizer or targeted comfort balm.
iS Clinical Super Serum Advance+
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Explore La Crem rewardsDullness, uneven tone; not sensitive
A vitamin C serum with copper tripeptide that brightens, evens the look of tone and softens fine lines.
Discover the formula & ingredientsPickup in Edmonton
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Boutique details
Your Edmonton boutique.
5238 Windermere Boulevard
Edmonton AB T6W 0L9
Canada
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Let’s talk about your skin and what belongs in your routine.
From our boutique to your door
Shipping, on usRegular $149+ · Priority $249+ CAD
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Selected with care.
iS Clinical
Super Serum Advance+
Your ritual begins with the right choice.
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The skincare focus
Vitamin C for brightness.
A vitamin C serum with copper tripeptide that brightens, evens the look of tone and softens fine lines.
Explore our ingredient glossaryiS Clinical
The formula, explained.
The ingredients behind this formula—and what they bring to your skin.
Ascorbic Acid
Vitamin C to brighten.
Tripeptide-1 (copper tripeptide)
Firmer, smoother-looking skin.
Arbutin and Polyporus Umbellatus (Mushroom) Extract
Even the look of tone.
Ingredient imagery is illustrative. Explore the full ingredient list below.
Made to work together
Pairs beautifully.
Cleansing Complex, Super Serum Advance+, Hydra-Cool Serum, moisturizer, Eclipse SPF 50+.
Your routine
iS ClinicalCleansing Complex
Why it fits
The cleansing step, before serums.
Worth knowing
The finer details.
A closer look at your skin, your routine and what goes into the formula.
iS Clinical Super Serum Advance+
iS Clinical Super Serum Advance+ pairs L-ascorbic acid with copper tripeptide.
Arbutin, mushroom extract and centella help even the look of tone and comfort the skin, with powerful antioxidant care.
Skin looks brighter, more even and smoother. Not for sensitive skin.
Why we love it
Our go-to iS Clinical vitamin C for brightness and visible firmness, beautiful in the morning under sunscreen.
Benefits
- Brightens
- Evens the look of tone
- Softens fine lines
- Firmer-looking skin
- Antioxidant care
Best for
Dullness, uneven tone; not sensitive
Mornings under sunscreen give the best brightening routine.
How to use
- Morning and/or evening, after cleansing.
- Smooth 4 to 5 drops over face and neck.
- Follow with moisturizer.
- Sunscreen every morning.
Precautions
Full Ingredient List
Water/Aqua/Eau, Ascorbic Acid, Hyaluronic Acid, Pentylene Glycol, Urea, Glucose, Guanidine, Tripeptide-1, Arbutin, Polyporus Umbellatus (Mushroom) Extract, Calcium Pantothenate, Asiaticoside, Asiatic Acid, Zinc Sulfate, Glycerin, Phenoxyethanol.
Ingredients may be updated by the manufacturer. Please refer to the product packaging for the most current ingredient list.
Shipping
For delivery and return information, view our policy.
A Brightening Vitamin C Serum for Smoother, More Even-Looking Skin
iS Clinical Super Serum Advance+ combines 15% L-ascorbic acid (vitamin C) with copper tripeptide, centella, arbutin and mushroom extract. It helps brighten the complexion, even the look of tone and soften the appearance of fine lines, while offering powerful antioxidant care.
Benefits
- Brightens a dull-looking complexion
- Helps even the look of skin tone and dark spots
- Helps soften the look of fine lines and wrinkles
- Supports firmer, smoother-looking skin
- Powerful antioxidant care against daily environmental stress
Best For
- Dullness and uneven-looking tone
- Fine lines and loss of firmness
- Normal, combination and oily skin
- Not recommended for sensitive or reactive skin
How to Use
- Morning and/or evening, after cleansing, apply 4 to 5 drops over the face and neck.
- Follow with Hydra-Cool Serum if you like, then moisturizer.
- Apply sunscreen every morning.
Loshen & Crem’s Recommendation
Super Serum Advance+ is the iS Clinical vitamin C we recommend for brightening and visible firmness. We love it in the morning under sunscreen. If your skin is sensitive, our team will usually suggest Pro-Heal Serum Advance+ instead.
Opening and Storage
Vitamin C formulas can fizz slightly when first opened, because of shaking and pressure changes during shipping. It does not affect the product. Open the cap a quarter turn, wait about 30 seconds, then continue a quarter turn at a time. Store at room temperature or below, away from direct sunlight, and do not freeze.
Ingredients
- L-Ascorbic Acid (Vitamin C): Brightens and provides antioxidant care.
- Copper Tripeptide (Tripeptide-1): Helps skin look firmer and smoother.
- Arbutin and Mushroom Extract: Help even the look of tone.
- Centella Asiatica Compounds: Help comfort the skin.
- Hyaluronic Acid: Hydrates.
Full Ingredient List
Water/Aqua/Eau, Ascorbic Acid, Hyaluronic Acid, Pentylene Glycol, Urea, Glucose, Guanidine, Tripeptide-1, Arbutin, Polyporus Umbellatus (Mushroom) Extract, Calcium Pantothenate, Asiaticoside, Asiatic Acid, Zinc Sulfate, Glycerin, Phenoxyethanol.
Ingredients may be updated by the manufacturer. Please refer to the product packaging for the most current ingredient list.
Frequently Asked Questions
Is it suitable for sensitive skin?
iS Clinical does not recommend it for sensitive skin. Pro-Heal Serum Advance+ is a gentler vitamin C option.
Why did my bottle fizz?
Vitamin C formulas can fizz after shipping. It does not affect the product.
Where can I buy iS Clinical Super Serum Advance+ in Canada?
iS Clinical Super Serum Advance+ is available from Loshen & Crem online across Canada and at our Edmonton, Alberta boutique.
The care behind your order
From our boutique.
To your door.
A few helpful details, before your next delivery.
Track your order01 · Across Canada
A good thing, on its way.
$149+Free Regular shipping
$249+Free Priority shipping
CAD · After discounts, before taxes and shipping. Conditions and product exclusions apply.
Canada & U.S. delivery details02 · Close to home
Collect in Edmonton.
Choose pickup at checkout when available. We’ll let you know when your order is ready.
Speak with our boutique03 · A little reassurance
Here after checkout, too.
Request an eligible return within 30 days. Items must be unopened, unused and in their original packaging. Final-sale exclusions apply.
Returns & order support
Ascorbic Acid
Vitamin C to brighten.
Tripeptide-1 (copper tripeptide)
Firmer, smoother-looking skin.
Arbutin and Polyporus Umbellatus (Mushroom) Extract
Even the look of tone.
Asiaticoside and Asiatic Acid
Comfort the skin.
Hyaluronic Acid
Hydrates.
Curious about your ingredients?
Explore La Matière
A little guidance. A more considered routine.
Your skin.
Our attention.
Beautiful formulas are only part of the story. Knowing what belongs in your routine makes all the difference.
Talk through your skin, the products you already use and the questions on your mind with one of our facialists.
Book your consultation Just a product question? Ask us.Personal guidance, in Edmonton or online.
The care behind your care
A place in your routine.
A team in your corner.
From your first question to your next replenishment, there’s a real person here to help.
01 Make sense of what you already use
You don’t need to start over. Bring us your current routine and we’ll help you understand where a new formula fits.
Ask our team02 Get to know your skin
Take our skin questionnaire for a thoughtful starting point, then speak with us if you’d like to explore your recommendations.
Find your starting point03 Keep the conversation going
A question about how to use it? Unsure about your next step? You’re welcome to come back to our team for guidance.
We’re here to helpFrom our Edmonton boutique
Explore iS Clinical.
Find your place to begin.
Discover iS Clinical Super Serum Advance+ at Loshen & Crem, a skin-health boutique and facial studio in Edmonton, Alberta. Explore the iS Clinical collection online across Canada, or speak with our facialists about how this formula fits into the products you already use.
A little care, to keep.
Your ritual, beautifully noted.
The guidance you’ll want when you get home: how to use it, what to expect and when to check in. A little reminder, with your team still in reach.