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Le Mieux24 Hr. Age Defying Cream
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A Loshen & Crem bestseller for lasting moisture, barrier support and smoother, firmer-looking skin

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Explore La Crem rewardsA peptide-rich daytime serum for firmer, smoother and more resilient-looking skin
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Edmonton AB T6W 0L9
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Le Mieux
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$180.00 CAD
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The skincare focus
A peptide-rich daytime serum for firmer, smoother and more resilient-looking skin
Explore our ingredient glossaryLe Mieux
The ingredients behind this formula—and what they bring to your skin.
Hya10+ Complex
Supports multi-level hydration and a smoother, plumper appearance.
Galactomyces Ferment Filtrate
Conditions the skin and supports hydration and visible radiance.
Niacinamide
Helps support the moisture barrier while improving the appearance of redness, dullness and uneven tone.
Ingredient imagery is illustrative. Explore the full ingredient list below.
Made to work together
Explore another step in your face-care routine.
Your routine
A Loshen & Crem bestseller for lasting moisture, barrier support and smoother, firmer-looking skin
Your routine
A nourishing peptide cleanser for soft, supple and comfortably clean skin
Worth knowing
A closer look at your skin, your routine and what goes into the formula.
A peptide-rich daytime serum for firmer, smoother and more resilient-looking skin
Le Mieux Youth Drops Daytime Firming Serum is an advanced morning treatment formulated to address dehydration, fine lines, uneven tone and early loss of elasticity. Its multi-peptide formula supports a firmer, more refined appearance while helping the skin remain comfortable throughout the day.
At the heart of the formula is Le Mieux’s Hya10+ Complex—a bioferment-based system featuring 10 forms of hyaluronic acid. Niacinamide, squalane, botanical oils, beta-glucan, aloe and panthenol complement the complex with barrier-supporting, conditioning and visibly calming benefits.
Youth Drops also contains an extensive blend of conventional and bioengineered peptides intended to support smoother, more resilient-looking skin. Although Le Mieux describes these as collagen-boosting peptides, the formula should be understood as a cosmetic age-supportive serum—not a treatment that physically lifts tissue or permanently restructures the skin.
Galactomyces Ferment Filtrate, Sodium Hyaluronate, Oryza Sativa (Rice) Bran Water, Hyaluronic Acid, Zinc Hydrolyzed Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Sodium Hyaluronate Dimethylsilanol, Sodium Hyaluronate Crosspolymer, C12-13 Alkyl Glyceryl Hydrolyzed Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Ascorbyl Propyl Hyaluronate, Saccharomyces/Rice Ferment Filtrate, Aloe Barbadensis Leaf Juice, Squalane, Niacinamide, Bacillus/Folic Acid Ferment Filtrate Extract, Citrullus Lanatus (Watermelon) Seed Oil, Simmondsia Chinensis (Jojoba) Seed Oil, Oligopeptide-225, Oligopeptide-223, sh-Polypeptide-123, Acetyl Hexapeptide-8, Acetyl Tetrapeptide-2, Palmitoyl Tripeptide-8, Dipeptide-2, Acetyl Tetrapeptide-5, Methyl Gluceth-20, Glycyrrhiza Glabra (Licorice) Root Extract, Beta-Glucan, Dimethyl Isosorbide, Poria Cocos Extract, sh-Oligopeptide-1, sh-Oligopeptide-2, Nonapeptide-1, Sodium DNA, Oryza Sativa (Rice) Bran Extract, Propanediol, Adansonia Digitata Fruit Extract, Oryza Sativa (Rice) Bran Oil, Hydrogenated Ethylhexyl Olivate, sh-Polypeptide-9, sh-Polypeptide-11, Bacillus/Soybean Ferment Extract, Glyceryl Oleate Citrate, Phospholipids, Octyldodecanol, Hydrogenated Olive Oil Unsaponifiables, Octyldodecyl Xyloside, Lysolecithin, Hydrolyzed Wheat Protein, Lecithin, Hydrolyzed Oat Protein, Acetyl Glutamine, Rosmarinus Officinalis (Rosemary) Leaf Extract, Hamamelis Virginiana (Witch Hazel) Water, Tasmannia Lanceolata Fruit/Leaf Extract, Helianthus Annuus (Sunflower) Extract, Sodium Polystyrene Sulfonate, Tocotrienols, Panthenol, Sclerotium Gum, Xanthan Gum, Pullulan, Glycerin, Tocopherol, Sodium Phytate, Sodium Citrate, Caprylyl Glycol, Ethylhexylglycerin, Undecylenoyl Glycine, Capryloyl Glycine.
Ingredient lists may change. Always refer to the product packaging for the most current ingredient list, particularly if you have allergies or sensitivities. Contact info@loshen.ca if you need help reviewing the formula before purchasing.
For delivery and return information, view our policy.
A peptide-rich daytime serum for firmer, smoother and more resilient-looking skin
Le Mieux Youth Drops Daytime Firming Serum is an advanced morning treatment formulated to address dehydration, fine lines, uneven tone and early loss of elasticity. Its multi-peptide formula supports a firmer, more refined appearance while helping the skin remain comfortable throughout the day.
At the heart of the formula is Le Mieux’s Hya10+ Complex—a bioferment-based system featuring 10 forms of hyaluronic acid. Niacinamide, squalane, botanical oils, beta-glucan, aloe and panthenol complement the complex with barrier-supporting, conditioning and visibly calming benefits.
Youth Drops also contains an extensive blend of conventional and bioengineered peptides intended to support smoother, more resilient-looking skin. Although Le Mieux describes these as collagen-boosting peptides, the formula should be understood as a cosmetic age-supportive serum—not a treatment that physically lifts tissue or permanently restructures the skin.
Youth Drops Daytime Firming Serum is particularly well suited to:
The formula contains many active peptides, ferments and botanical extracts. Highly reactive skin should patch test and introduce it gradually rather than assuming that a fragrance-free formula will automatically be sensitivity-free.
Youth Drops combines the hydration of a hyaluronic acid serum with the broader benefits of peptides, niacinamide, antioxidants, ferments and barrier-supporting lipids.
It is designed specifically as a daytime serum. The formula helps prepare the complexion for daily environmental exposure while supporting hydration, smoothness and visible firmness beneath moisturizer and sunscreen.
Use every morning.
After cleansing and toning, apply a small amount evenly over the face, neck and décolleté. Gently press or smooth the serum into the skin until absorbed.
Follow with moisturizer when needed, then apply broad-spectrum sunscreen as the final morning skincare step.
For oily or combination skin, Youth Drops may provide enough conditioning beneath sunscreen without an additional moisturizer. Dry or mature skin will generally benefit from moisturizer applied afterward.
Avoid direct contact with the eyes. Use Eye Revive Firming Cream around the orbital contour.
Youth Drops is an excellent daytime choice for clients who want more than basic hydration but do not necessarily want a strong acid or vitamin C treatment every morning. It combines hydration, peptides, tone support and barrier care in one sophisticated formula.
Use a modest amount and allow it to settle before applying moisturizer or sunscreen. Applying too many layers—or too much of each layer—can create pilling without improving results.
For dry or mature skin, follow with Bio Cell Rejuvenating Cream or 24 Hr. Age Defying Cream. For normal, combination or sensitive skin, Essence Moisturizer provides a lighter finish.
Youth Drops contains antioxidants, but it is not a sunscreen. Antioxidant skincare complements daily sun protection; it does not replace it.
If your skin is highly reactive, begin every other morning. The formula is fragrance-free according to the published INCI, but it contains witch hazel water, rosemary extract, multiple ferments and a large peptide complex. Skin tolerance is always individual.
A separate hyaluronic acid serum is not essential when using Youth Drops because the formula already contains Le Mieux’s 10-form Hya10+ Complex.
These Le Mieux serums overlap in hydration and age support, but each has a different emphasis.
Most clients do not need to layer several Le Mieux peptide serums together. Select the formula that best matches your primary concern and preferred texture.
Youth Drops cannot physically lift sagging tissue or reproduce the effect of an in-office procedure. Its visible firming benefits come from hydration, film-forming ingredients, emollients and peptides that support a smoother, more resilient appearance over time.
Hyaluronic acid and pullulan may create a more immediate feeling of smoothness and temporary tightness. Peptides, niacinamide and barrier-supporting ingredients require consistent use to support longer-term cosmetic improvements.
Le Mieux does not publish a finished-product clinical trial or percentage-based consumer study for Youth Drops on its current public product page. Results should therefore be presented as cosmetic benefits rather than guaranteed clinical outcomes.
Youth Drops contains several categories of peptides:
Le Mieux specifically describes sh-oligopeptide-1 as a laboratory-synthesized peptide that mimics epidermal growth factor. It is not a living cell, injectable growth factor or a medical treatment.
The Hya10+ Complex combines 10 forms of hyaluronic acid:
These ingredients differ in molecular structure and skin affinity, allowing the formula to support hydration across the skin’s surface. They help the complexion appear smoother and temporarily plumper but do not create permanent facial volume.
Youth Drops includes niacinamide, vitamin E, botanical extracts and fermented ingredients that provide antioxidant and barrier-supporting benefits. These ingredients may help the skin manage the visible effects associated with environmental exposure.
They do not block ultraviolet radiation. A broad-spectrum sunscreen remains necessary every morning, even when Youth Drops is used consistently.
Full Ingredient List:
Galactomyces Ferment Filtrate, Sodium Hyaluronate, Oryza Sativa (Rice) Bran Water, Hyaluronic Acid, Zinc Hydrolyzed Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Sodium Hyaluronate Dimethylsilanol, Sodium Hyaluronate Crosspolymer, C12-13 Alkyl Glyceryl Hydrolyzed Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Ascorbyl Propyl Hyaluronate, Saccharomyces/Rice Ferment Filtrate, Aloe Barbadensis Leaf Juice, Squalane, Niacinamide, Bacillus/Folic Acid Ferment Filtrate Extract, Citrullus Lanatus (Watermelon) Seed Oil, Simmondsia Chinensis (Jojoba) Seed Oil, Oligopeptide-225, Oligopeptide-223, sh-Polypeptide-123, Acetyl Hexapeptide-8, Acetyl Tetrapeptide-2, Palmitoyl Tripeptide-8, Dipeptide-2, Acetyl Tetrapeptide-5, Methyl Gluceth-20, Glycyrrhiza Glabra (Licorice) Root Extract, Beta-Glucan, Dimethyl Isosorbide, Poria Cocos Extract, sh-Oligopeptide-1, sh-Oligopeptide-2, Nonapeptide-1, Sodium DNA, Oryza Sativa (Rice) Bran Extract, Propanediol, Adansonia Digitata Fruit Extract, Oryza Sativa (Rice) Bran Oil, Hydrogenated Ethylhexyl Olivate, sh-Polypeptide-9, sh-Polypeptide-11, Bacillus/Soybean Ferment Extract, Glyceryl Oleate Citrate, Phospholipids, Octyldodecanol, Hydrogenated Olive Oil Unsaponifiables, Octyldodecyl Xyloside, Lysolecithin, Hydrolyzed Wheat Protein, Lecithin, Hydrolyzed Oat Protein, Acetyl Glutamine, Rosmarinus Officinalis (Rosemary) Leaf Extract, Hamamelis Virginiana (Witch Hazel) Water, Tasmannia Lanceolata Fruit/Leaf Extract, Helianthus Annuus (Sunflower) Extract, Sodium Polystyrene Sulfonate, Tocotrienols, Panthenol, Sclerotium Gum, Xanthan Gum, Pullulan, Glycerin, Tocopherol, Sodium Phytate, Sodium Citrate, Caprylyl Glycol, Ethylhexylglycerin, Undecylenoyl Glycine, Capryloyl Glycine.
Ingredient lists may change. Always refer to the product packaging for the most current ingredient list, particularly if you have allergies or sensitivities. Contact info@loshen.ca if you need help reviewing the formula before purchasing.
Youth Drops is a peptide-rich morning serum formulated to support hydration, visible firmness, barrier function, resilience and a more even-looking complexion.
The formula combines hydration, antioxidants, niacinamide, peptides and barrier-supporting ingredients intended to help prepare the skin for daily environmental exposure. It should be followed with sunscreen.
It does not contain an ingredient that restricts it to daytime use, but Le Mieux specifically positions and directs it as a morning serum. A dedicated nighttime treatment may provide more complementary benefits.
No. It contains antioxidant and barrier-supporting ingredients, but it does not provide an SPF rating or replace broad-spectrum sunscreen.
It can create a smoother, firmer and temporarily tightened appearance through hydration, film-forming ingredients and consistent peptide care. It cannot physically lift facial tissue or reproduce an in-office lifting procedure.
The formula contains several lab-created sh-oligopeptides and sh-polypeptides. Le Mieux describes sh-oligopeptide-1 as a peptide that mimics epidermal growth factor. These are cosmetic signaling ingredients—not living cells or injectable treatments.
No exosomes are identified in the published ingredient list, and Youth Drops should not be described or marketed as an exosome serum.
Le Mieux lists it for oily, normal-to-oily, normal, normal-to-dry and dry skin. Individual tolerance and preferred texture will still vary.
The formula contains soothing ingredients and no added fragrance is listed, but it also contains numerous peptides, ferments, witch hazel water and rosemary extract. Reactive skin should patch test and begin every other morning.
Niacinamide, beta-glucan, aloe, palmitoyl tripeptide-8 and Poria cocos extract may help improve the appearance of mild redness. Youth Drops is not a treatment for rosacea or persistent inflammatory skin conditions.
Niacinamide, nonapeptide-1 and licorice root extract support a brighter, more even-looking complexion. For persistent or significant pigmentation, a more targeted brightening treatment may be required.
For many clients, yes. Youth Drops already contains the complete Hya10+ Complex. Hyaluronic Serum may be preferable when hydration is the only concern or when a simpler formula is desired.
It is possible, but often unnecessary. If the skin is exceptionally dehydrated, apply Hyaluronic Serum first and Youth Drops second, using small amounts to reduce the risk of pilling.
Yes. Youth Drops can generally be layered with a well-tolerated vitamin C serum. Apply the thinner product first and introduce the combination gradually if your skin is reactive.
Youth Drops already contains niacinamide. Adding another high-niacinamide serum is unlikely to be necessary and may complicate the routine.
Yes. Use Youth Drops in the morning and retinol at night. Apply sunscreen consistently during the day.
Yes. A practical routine is Youth Drops in the morning and Le Mieux Brightening Serum at night.
Both are peptide-rich, hydrating formulas, so layering them may be excessive. Use Youth Drops during the day and Collagen Peptide Serum at night, or select one according to your texture preference and primary concerns.
Avoid applying directly onto the eyelids or close to the lash line. Use Eye Revive Firming Cream around the orbital contour.
Yes. Apply a modest amount and allow it to absorb before moisturizer, sunscreen and makeup. Using too much may contribute to pilling.
No parfum, added fragrance or essential oils appear in the current published ingredient list. Botanical extracts and fermented ingredients may still give the formula a natural scent.
The published ingredient list contains hydrolyzed wheat protein. It should not be marketed as gluten-free without direct confirmation from the manufacturer.
No retinol, retinoid, glycolic acid, lactic acid or salicylic acid appears in the published ingredient list.
No retinoid is listed, but pregnancy and breastfeeding safety information for many specialized cosmetic peptides remains limited. Consult your physician or qualified healthcare provider before use.
Only when the treatment provider confirms that the skin is ready for regular skincare. Do not apply it to broken, actively peeling or significantly irritated skin.
Hydration and surface smoothness may be noticed relatively quickly. Improvements in fine lines, firmness, redness and uneven tone require consistent use and will vary. Le Mieux does not publish a specific finished-product clinical timeline on its public product page.
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Request an eligible return within 30 days. Items must be unopened, unused and in their original packaging. Final-sale exclusions apply.
Returns & order support
Supports multi-level hydration and a smoother, plumper appearance.
Conditions the skin and supports hydration and visible radiance.
Helps support the moisture barrier while improving the appearance of redness, dullness and uneven tone.
Provides additional conditioning and antioxidant support.
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We’re here to helpFrom our Edmonton boutique
Discover Le Mieux Youth Drops Daytime Firming Serum at Loshen & Crem, a skin-health boutique and facial studio in Edmonton, Alberta. Explore the Le Mieux collection online across Canada, or speak with our facialists about how this formula fits into the products you already use.
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