Your routine
Biologique RechercheLotion P50T
Why it fits
Biologique Recherche’s exfoliating, purifying and balancing lotion for seborrheic Skin Instants. The first step after cleansing.

Skincare Boutique & Facial Institute
Skincare Boutique & Facial Institute
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Explore La Crem rewardsFirst signs of wrinkles
An intensive smoothing mask for Skin Instants showing the first signs of wrinkles, from expression lines to more settled lines. In 15 to 20 minutes, wrinkles look softer and skin looks smoother and more rested.
Discover the formula & ingredientsPickup in Edmonton
Usually ready in 24 hours
5238 Windermere Boulevard
Edmonton AB T6W 0L9
Canada
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Biologique Recherche
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$230.00 CAD
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The skincare focus
An intensive smoothing mask for Skin Instants showing the first signs of wrinkles, from expression lines to more settled lines. In 15 to 20 minutes, wrinkles look softer and skin looks smoother and more rested.
Explore our ingredient glossaryBiologique Recherche
The ingredients behind this formula—and what they bring to your skin.
Acetyl Hexapeptide-8
Biologique Recherche's Myorelax Peptide, included to help reduce the appearance of expression lines.
Biosaccharide Gum-1
A moisture-supporting polysaccharide that helps improve hydration and skin comfort.
Glycerin
Helps attract and maintain water in the skin for comfort and a visibly plumper look.
Ingredient imagery is illustrative. Explore the full ingredient list below.
Made to work together
Cleanse, apply the Lotion P50 selected for your Skin Instant, then Masque Biofixine for 15 to 20 minutes. After rinsing, follow with your serums, such as Sérum Élastine for ongoing elasticity and wrinkle care, and finish with your cream, such as Crème Biofixine for daily wrinkle-focused moisture. Use dedicated eye-contour care around the eyes.
Your routine
Biologique Recherche’s exfoliating, purifying and balancing lotion for seborrheic Skin Instants. The first step after cleansing.
Your routine
The targeted serum step for elasticity and wrinkle smoothing, applied after cleansing, Lotion P50 and any lighter serums, and before your moisturizer.
Worth knowing
A closer look at your skin, your routine and what goes into the formula.
Your face is supposed to move. The conversation changes when smile lines and forehead lines begin to stay visible even after the expression has relaxed. Biologique Recherche Masque Biofixine is an intensive smoothing mask designed for both expression lines created by repeated movement and more settled wrinkles associated with changes in the skin over time.
At the heart of the formula is Acetyl Hexapeptide-8, the peptide Biologique Recherche calls its Myorelax Peptide, selected to help reduce the appearance of expression lines. Hydrating, antioxidant and film-forming ingredients complement it by plumping the look of dehydration lines and helping maintain the integrity of the skin barrier.
After 15 to 20 minutes, wrinkles appear softer, skin looks smoother and facial features look more relaxed and refined. The purpose is cosmetic: your face will still move and you will still smile, but expression-related lines look smoother and less pronounced.
Masque Biofixine is what we think about when a client tells us their forehead lines are starting to stay, or that they can see their expression lines even when they aren't making the expression. Its personality is wrinkle smoothing, not facial restructuring: if the concern is a changing jawline, we would rather talk about Platysma or VG Tensil. We also love it before an event, when tired or dehydrated skin makes lines look more pronounced.
First signs of wrinkles
Rinse this one with warm water, not cold: it is a detail worth noting, since many other Biologique Recherche masks call for cold-water removal.
Water (Aqua), Stearic Acid, Kaolin, Palmitic Acid, Glycerin, Propylene Glycol, Macadamia Ternifolia Seed Oil, Cetyl Alcohol, Pentylene Glycol, Polysorbate 40, Calcium Carbonate, PEG-2 Stearate, Vitis Vinifera (Grape) Seed Oil, Gossypium Herbaceum (Cotton) Seed Oil, Helianthus Annuus (Sunflower) Seed Oil, Tapioca Starch, Caprylyl Glycol, Triethanolamine, Phenoxyethanol, Tocopheryl Acetate, Biosaccharide Gum-1, 1,2-Hexanediol, Nasturtium Officinale Extract, Alteromonas Ferment Extract, Juglans Regia (Walnut) Seed Extract, Magnesium Stearate, Phenethyl Alcohol, TEA-Stearate, DATEM, Sunflower Seed Oil Glycerides, Benzoic Acid, Pimpinella Anisum (Anise) Fruit Extract, Rosmarinus Officinalis (Rosemary) Leaf Extract, Acetyl Hexapeptide-8, Anise Alcohol, Disodium EDTA, Limonene, Linalool, Sodium Metabisulfite, Sorbic Acid.
Expression lines are associated with repeated facial movements such as smiling, squinting or raising the eyebrows. Static wrinkles stay visible when the face is relaxed and are associated with changes in the skin over time. Masque Biofixine is formulated to improve the appearance of both.
No. Its Myorelax Peptide works cosmetically on the appearance of expression lines; your face will still move and you will still smile.
Yes. Its hydrating ingredients help plump the look of dehydration lines while supporting the skin barrier.
Its focus is wrinkles and expression lines. Features can look more refined after use, but if sagging or jawline definition is the main concern, VG Tensil, Platysma or Masque Caviar Vert may be more targeted.
Biologique Recherche recommends 15 to 20 minutes, then rinse thoroughly with warm water.
Masque Biofixine is occasional, intensive care for wrinkles and expression lines. Crème Biofixine is the ongoing, wrinkle-focused moisturizing step of your daily routine.
Yes. The formula contains ingredients derived from walnut and macadamia. If you have a nut allergy, please book a consultation with one of our estheticians before purchasing.
At Loshen & Crem, we want to ensure you have the best possible experience with Biologique Recherche. Before purchasing any Biologique Recherche product, we highly recommend booking a consultation with one of our estheticians. Consultations are available virtually through Google Meet or in person at our Edmonton boutique. An appointment is required.
In the event of a reaction, Biologique Recherche requires photos of the reaction and the product, the lot number found on the product or the bottom of the box, and proof of a consultation with one of our estheticians before they can review the concern.
If you choose to purchase without a consultation and experience a reaction, we will be unable to provide a refund. Our team is always happy to answer your questions and help you select the products best suited to your skin.
For delivery and return information, view our policy.
Your face is supposed to move. The conversation changes when smile lines and forehead lines begin to stay visible even after the expression has relaxed. Biologique Recherche Masque Biofixine is an intensive smoothing mask designed for both expression lines created by repeated movement and more settled wrinkles associated with changes in the skin over time.
At the heart of the formula is Acetyl Hexapeptide-8, the peptide Biologique Recherche calls its Myorelax Peptide, selected to help reduce the appearance of expression lines. Hydrating, antioxidant and film-forming ingredients complement it by plumping the look of dehydration lines and helping maintain the integrity of the skin barrier.
After 15 to 20 minutes, wrinkles appear softer, skin looks smoother and facial features look more relaxed and refined. The purpose is cosmetic: your face will still move and you will still smile, but expression-related lines look smoother and less pronounced.
Water (Aqua), Stearic Acid, Kaolin, Palmitic Acid, Glycerin, Propylene Glycol, Macadamia Ternifolia Seed Oil, Cetyl Alcohol, Pentylene Glycol, Polysorbate 40, Calcium Carbonate, PEG-2 Stearate, Vitis Vinifera (Grape) Seed Oil, Gossypium Herbaceum (Cotton) Seed Oil, Helianthus Annuus (Sunflower) Seed Oil, Tapioca Starch, Caprylyl Glycol, Triethanolamine, Phenoxyethanol, Tocopheryl Acetate, Biosaccharide Gum-1, 1,2-Hexanediol, Nasturtium Officinale Extract, Alteromonas Ferment Extract, Juglans Regia (Walnut) Seed Extract, Magnesium Stearate, Phenethyl Alcohol, TEA-Stearate, DATEM, Sunflower Seed Oil Glycerides, Benzoic Acid, Pimpinella Anisum (Anise) Fruit Extract, Rosmarinus Officinalis (Rosemary) Leaf Extract, Acetyl Hexapeptide-8, Anise Alcohol, Disodium EDTA, Limonene, Linalool, Sodium Metabisulfite, Sorbic Acid.
At Loshen & Crem, we want to ensure you have the best possible experience with Biologique Recherche. Before purchasing any Biologique Recherche product, we highly recommend booking a consultation with one of our estheticians. Consultations are available virtually through Google Meet or in person at our Edmonton boutique. An appointment is required.
In the event of a reaction, Biologique Recherche requires photos of the reaction and the product, the lot number found on the product or the bottom of the box, and proof of a consultation with one of our estheticians before they can review the concern.
If you choose to purchase without a consultation and experience a reaction, we will be unable to provide a refund. Our team is always happy to answer your questions and help you select the products best suited to your skin.
The care behind your order
A few helpful details, before your next delivery.
Track your order01 · Across Canada
$149+Free Regular shipping
$249+Free Priority shipping
CAD · After discounts, before taxes and shipping. Conditions and product exclusions apply.
Canada & U.S. delivery details02 · Close to home
Choose pickup at checkout when available. We’ll let you know when your order is ready.
Speak with our boutique03 · Care you can count on
Request an eligible return within 30 days. Items must be unopened, unused and in their original packaging. Final-sale exclusions apply.
Returns & order support
Biologique Recherche's Myorelax Peptide, included to help reduce the appearance of expression lines.
A moisture-supporting polysaccharide that helps improve hydration and skin comfort.
Helps attract and maintain water in the skin for comfort and a visibly plumper look.
A marine-derived ferment included in the smoothing and conditioning complex.
Botanical oils that help nourish, soften and condition the skin, with antioxidant support from grape seed oil.
Provides botanical antioxidant support.
Curious about your ingredients?
Explore La Matière
Expert guidance. A considered routine.
Beautiful formulas are only part of the story. Knowing what belongs in your routine makes all the difference.
Talk through your skin, the products you already use and the questions on your mind with one of our facialists.
Book a consultation Just a product question? Ask us.The care behind your care
From your first question to your next replenishment, there’s a real person here to help.
You don’t need to start over. Bring us your current routine and we’ll help you understand where a new formula fits.
Ask our teamTake our skin questionnaire for a thoughtful starting point, then speak with us if you’d like to explore your recommendations.
Find your starting pointA question about how to use it? Unsure about your next step? You’re welcome to come back to our team for guidance.
We’re here to helpFrom our Edmonton boutique
Discover Biologique Recherche Masque Biofixine at Loshen & Crem, a skin-health boutique and facial studio in Edmonton, Alberta. Explore the Biologique Recherche collection online across Canada, or speak with our facialists about how this formula fits into the products you already use.
Care, to keep.
The guidance you’ll want when you get home: how to use it, what to expect and when to check in. Your reminder, with your team still in reach.
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