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Le Mieux24 Hr. Age Defying Cream
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A Loshen & Crem bestseller for lasting moisture, barrier support and smoother, firmer-looking skin

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Explore La Crem rewardsA multi-pathway nighttime serum for dark spots, uneven tone and dehydrated skin
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Edmonton AB T6W 0L9
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Le Mieux
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$135.00 CAD
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The skincare focus
A multi-pathway nighttime serum for dark spots, uneven tone and dehydrated skin
Explore our ingredient glossaryLe Mieux
The ingredients behind this formula—and what they bring to your skin.
Azelaic Acid
Helps improve the appearance of discoloration, congestion and uneven texture.
Tranexamic Acid
Supports a more even-looking complexion and helps target persistent dark spots.
Niacinamide
Supports the moisture barrier while improving the appearance of dullness and uneven tone.
Ingredient imagery is illustrative. Explore the full ingredient list below.
Made to work together
Explore another step in your face-care routine.
Your routine
A Loshen & Crem bestseller for lasting moisture, barrier support and smoother, firmer-looking skin
Your routine
A nourishing peptide cleanser for soft, supple and comfortably clean skin
Worth knowing
A closer look at your skin, your routine and what goes into the formula.
A multi-pathway nighttime serum for dark spots, uneven tone and dehydrated skin
Award-winning Le Mieux Brightening Serum is a creamy nighttime treatment formulated to improve the appearance of sun-induced dark spots, post-blemish marks, dullness and uneven pigmentation. Rather than relying on one brightening ingredient, it combines azelaic acid, tranexamic acid, niacinamide, alpha-arbutin, vitamin C derivatives, diacetyl boldine, licorice root and mulberry leaf extract.
The formula also includes the Hya10+ Complex—10 forms of hyaluronic acid—to support hydration and visible plumpness while ceramide NP, botanical oils, shea butter and phospholipids help condition the moisture barrier. Galactomyces ferment filtrate forms the base, complemented by antioxidants and peptides for a smoother, more luminous-looking complexion.
Brightening Serum is intended to improve uneven-looking pigmentation, not bleach the skin or eliminate its natural melanin. Consistent nighttime use must be paired with diligent daytime sun protection; otherwise, new exposure can undermine progress.
Galactomyces Ferment Filtrate, Sodium Hyaluronate, Oryza Sativa (Rice) Bran Water, Hyaluronic Acid, Zinc Hydrolyzed Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Sodium Hyaluronate Dimethylsilanol, Sodium Hyaluronate Crosspolymer, C12-13 Alkyl Glyceryl Hydrolyzed Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Ascorbyl Propyl Hyaluronate, Pyrus Malus (Apple) Fruit Water, Malus Domestica Fruit Cell Culture Extract, Lecithin, Azelaic Acid, Ceramide NP, Tranexamic Acid, Niacinamide, Dipalmitoyl Hydroxyproline, Epigallocatechin Gallatyl Glucoside, Alpha Arbutin, Teprenone, Oligopeptide-225, Acetyl Octapeptide-3, Palmitoyl Tetrapeptide-7, Maltodextrin, Bisabolol, Palmitoyl Tripeptide-1, Palmitoyl Pentapeptide-4, Tetrahexyldecyl Ascorbate, Allantoin, Bidens Pilosa Extract, Diacetyl Boldine, Elaeis Guineensis (Palm) Oil, Oryza Sativa (Rice) Bran Oil, Gossypium Herbaceum Seed Oil, Caprylic/Capric Triglyceride, Linum Usitatissimum (Linseed) Seed Oil, Glycyrrhiza Glabra (Licorice) Root Extract, Morus Alba Leaf Extract, Tocotrienols, Cyclodextrin, Glycolipids, Aloe Barbadensis Leaf Extract, Phospholipids, Butyrospermum Parkii (Shea) Butter, Vaccinium Myrtillus Fruit Extract, Hydroxyethylcellulose, Tocopherol, Soy Isoflavones, Caprylyl Glycol, Ethylhexylglycerin, Undecylenoyl Glycine, Capryloyl Glycine.
Ingredient lists may change. Always refer to the product packaging for the most current ingredient list, particularly if you have allergies or sensitivities. Contact info@loshen.ca if you need help reviewing the formula before purchasing.
For delivery and return information, view our policy.
A multi-pathway nighttime serum for dark spots, uneven tone and dehydrated skin
Award-winning Le Mieux Brightening Serum is a creamy nighttime treatment formulated to improve the appearance of sun-induced dark spots, post-blemish marks, dullness and uneven pigmentation. Rather than relying on one brightening ingredient, it combines azelaic acid, tranexamic acid, niacinamide, alpha-arbutin, vitamin C derivatives, diacetyl boldine, licorice root and mulberry leaf extract.
The formula also includes the Hya10+ Complex—10 forms of hyaluronic acid—to support hydration and visible plumpness while ceramide NP, botanical oils, shea butter and phospholipids help condition the moisture barrier. Galactomyces ferment filtrate forms the base, complemented by antioxidants and peptides for a smoother, more luminous-looking complexion.
Brightening Serum is intended to improve uneven-looking pigmentation, not bleach the skin or eliminate its natural melanin. Consistent nighttime use must be paired with diligent daytime sun protection; otherwise, new exposure can undermine progress.
Brightening Serum is particularly well suited to:
Brightening Serum is not intended to remove raised, indented or structural acne scars. Persistent melasma or rapidly changing pigmentation should be assessed by a qualified skincare or medical professional.
Brightening Serum approaches uneven pigmentation through several complementary cosmetic pathways while supporting hydration and the moisture barrier.
It is not a lightweight acid solution. The creamy formula pairs pigment-focused ingredients with hyaluronic acid forms, ceramide, peptides, shea butter and botanical oils, making it especially relevant when pigmentation is accompanied by dryness or visible signs of aging.
Use at night only.
After cleansing and toning, gently pat one to two pumps onto the face and neck, avoiding the eyelids and immediate eye area. Apply after lightweight, water-based serums and before moisturizer.
For sensitive skin or those new to multi-active brightening treatments, begin every other evening for one to two weeks. Increase to nightly use only if the skin remains comfortable.
During the introduction period, avoid applying Brightening Serum in the same routine as retinol, strong exfoliating acids, peel pads or another concentrated pigmentation treatment.
Apply a broad-spectrum sunscreen every morning and reapply during prolonged daylight exposure. Consistent sun protection is essential when trying to improve discoloration.
Pigmentation requires patience and consistency. Apply Brightening Serum across the full area affected by uneven tone rather than chasing individual spots with excessive product. One pump may be sufficient for the face; use a second pump when extending the treatment to the neck.
Because the formula is creamy and contains shea butter, ceramide and botanical oils, dry and mature skin may appreciate its cushioning texture. Combination or congestion-prone skin should begin with a smaller amount and monitor how the skin responds.
If you use a dedicated vitamin C serum, apply it in the morning and reserve Brightening Serum for the evening. This creates a focused routine without stacking every brightening ingredient at once.
For melasma, Brightening Serum may provide helpful cosmetic support, but it should not be presented as a cure. Melasma is persistent and influenced by several factors, including UV exposure, visible light, heat and hormones. A professionally selected Cyspera, Meline or Cosmelan program may be more appropriate for some clients.
Do not place Brightening Serum inside the Le Mieux Ionized Oxygen Infuser. Le Mieux specifically identifies it as incompatible with the device. Apply it directly to the skin by hand.
Morning:
Evening:
Brightening Toner, peel pads and stronger exfoliating treatments can be used on alternate evenings if appropriate. They do not need to accompany Brightening Serum every night.
These products support radiance in different ways.
Most clients do not need Brightening Toner, Perfect Renewal and Brightening Serum in the same evening.
These concerns are related but not identical.
Brightening Serum is best positioned for the visible appearance of excess pigmentation. It is not a medical treatment for melasma or structural scarring.
Le Mieux states that Brightening Serum is clinically shown to reduce melanin synthesis by up to 80% and minimize the appearance of UV-induced dark spots by 42–56%.
However, the current public product page does not disclose the number of participants, testing duration, study design or whether both percentages were measured using the complete finished formula rather than individual ingredient testing.
Loshen & Crem therefore presents these figures as manufacturer-reported results, not guaranteed outcomes. Individual results depend on the type and depth of pigmentation, consistency of use, sun exposure and the complete skincare routine.
Melanin is the natural pigment that gives colour to the skin and helps protect it against ultraviolet exposure. The goal of a brightening serum is not to eliminate melanin or lighten someone’s natural skin tone.
A responsible pigmentation routine focuses on areas where pigment has become uneven or excessive while protecting the surrounding skin from inflammation and additional exposure.
This distinction is especially important for deeper skin tones, where irritation and aggressive exfoliation can trigger further post-inflammatory pigmentation.
Despite its name, azelaic acid is not an alpha hydroxy acid or beta hydroxy acid. It is a dicarboxylic acid used in skincare to support clearer-looking pores, more even tone and smoother texture.
The concentration and pH of azelaic acid in Brightening Serum are not disclosed. The formula should not be compared directly with a prescription azelaic acid treatment or assumed to function as a high-strength chemical peel.
Brightening Serum contains 10 forms of hyaluronic acid:
Together, they support moisture retention, visible surface plumping and skin comfort. They do not create permanent volume or function like injectable hyaluronic acid.
Full Ingredient List:
Galactomyces Ferment Filtrate, Sodium Hyaluronate, Oryza Sativa (Rice) Bran Water, Hyaluronic Acid, Zinc Hydrolyzed Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Sodium Hyaluronate Dimethylsilanol, Sodium Hyaluronate Crosspolymer, C12-13 Alkyl Glyceryl Hydrolyzed Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Ascorbyl Propyl Hyaluronate, Pyrus Malus (Apple) Fruit Water, Malus Domestica Fruit Cell Culture Extract, Lecithin, Azelaic Acid, Ceramide NP, Tranexamic Acid, Niacinamide, Dipalmitoyl Hydroxyproline, Epigallocatechin Gallatyl Glucoside, Alpha Arbutin, Teprenone, Oligopeptide-225, Acetyl Octapeptide-3, Palmitoyl Tetrapeptide-7, Maltodextrin, Bisabolol, Palmitoyl Tripeptide-1, Palmitoyl Pentapeptide-4, Tetrahexyldecyl Ascorbate, Allantoin, Bidens Pilosa Extract, Diacetyl Boldine, Elaeis Guineensis (Palm) Oil, Oryza Sativa (Rice) Bran Oil, Gossypium Herbaceum Seed Oil, Caprylic/Capric Triglyceride, Linum Usitatissimum (Linseed) Seed Oil, Glycyrrhiza Glabra (Licorice) Root Extract, Morus Alba Leaf Extract, Tocotrienols, Cyclodextrin, Glycolipids, Aloe Barbadensis Leaf Extract, Phospholipids, Butyrospermum Parkii (Shea) Butter, Vaccinium Myrtillus Fruit Extract, Hydroxyethylcellulose, Tocopherol, Soy Isoflavones, Caprylyl Glycol, Ethylhexylglycerin, Undecylenoyl Glycine, Capryloyl Glycine.
Ingredient lists may change. Always refer to the product packaging for the most current ingredient list, particularly if you have allergies or sensitivities. Contact info@loshen.ca if you need help reviewing the formula before purchasing.
It is formulated to improve the appearance of sun-induced dark spots, uneven tone, dullness and flat post-blemish marks.
It may support a more even-looking complexion within a melasma routine, but it is not a cure or prescription treatment. Melasma is persistent and frequently requires a broader plan involving strict sun protection and professionally selected treatments.
Yes, it may help improve flat brown or grey post-blemish marks. It will not remove raised or indented acne scars.
No. The goal is to improve uneven pigmentation and restore visible clarity, not alter the skin’s natural colour.
No hydroquinone appears in the current published ingredient list.
No retinol or retinoid appears in the current ingredient list. Bidens pilosa is a botanical extract and should not be described as retinol.
Yes. The formula contains tetrahexyldecyl ascorbate and ascorbyl propyl hyaluronate, two vitamin C–related ingredients.
Le Mieux does not disclose the percentage of azelaic acid in the current formula. It should not be compared directly with a prescription or single-active azelaic acid treatment.
Begin every other evening if you are new to brightening treatments or have sensitive skin. Increase to nightly use when the skin remains comfortable.
Le Mieux directs Brightening Serum for nighttime use only. Apply a separate antioxidant serum and broad-spectrum sunscreen during the day.
Pigmentation changes gradually. Allow approximately eight to twelve weeks of consistent use before assessing progress, while recognizing that results vary and no specific timeline is guaranteed by the current product information.
Yes. Daily broad-spectrum sunscreen is essential. Without consistent protection, UV and visible-light exposure can darken existing pigmentation and encourage new discoloration.
The formula can support uneven pigmentation across skin tones. Deeper skin tones should introduce active treatments cautiously because irritation itself can lead to additional post-inflammatory pigmentation.
Potentially, but the formula combines several active brightening ingredients. Patch test first, begin every other evening and avoid combining it immediately with several exfoliants or retinoids.
No parfum, fragrance or essential oils appear in the published ingredient list. Individual sensitivity to botanical extracts and other components can still vary.
Possibly, but the creamy formula contains shea butter, palm oil, rice bran oil, cottonseed oil, linseed oil and other emollients. These ingredients are not automatically pore-clogging, but the texture may feel rich on very oily skin. It is not an acne medication.
Use them on alternate evenings when beginning. Combining a retinoid with this multi-active brightening serum may increase dryness or irritation.
Alternate Brightening Serum with peel pads, glycolic acid, mandelic acid or salicylic acid until tolerance has been established. Daily use of multiple active treatments is unnecessary for most clients.
Yes. A practical routine is Vita-C Serum in the morning and Brightening Serum at night, followed by daily sunscreen.
Some clients may tolerate the combination, but both products contain active brightening ingredients. Loshen & Crem recommends beginning on alternate evenings, particularly for sensitive or dehydration-prone skin.
It can be applied to targeted areas, but pigmentation is often more widespread than the most visible spots. A thin, even layer across the affected area generally supports a more uniform-looking result.
Avoid the eyelids and immediate eye contour. Use a dedicated eye product for that area.
Le Mieux directs application to the face and neck. It may also be extended cautiously to the décolleté if the skin tolerates it, followed by daily sun protection.
No. Le Mieux specifically identifies Brightening Serum as incompatible with the Ionized Oxygen Infuser. Apply it directly by hand.
Because it is a creamy, emollient-rich serum, Loshen & Crem prefers applying it by hand. Use a lighter water-based serum for the Skin Perfecter’s serum-application technique.
Only after the professional who performed the procedure confirms that the skin is fully healed. Introducing a multi-active brightening serum too early may increase irritation and post-inflammatory pigmentation.
The formula contains alpha-arbutin, tranexamic acid and several other active brightening ingredients. Pregnancy and breastfeeding safety data for complete cosmetic formulas remain limited. Consult your physician or qualified healthcare provider before use.
Le Mieux reports up to an 80% reduction in melanin synthesis and a 42–56% reduction in the appearance of UV-induced dark spots. The current public product page does not provide the study design, number of participants, duration or sufficient information to determine whether these percentages relate to the complete formula. Individual results are not guaranteed.
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Returns & order support
Helps improve the appearance of discoloration, congestion and uneven texture.
Supports a more even-looking complexion and helps target persistent dark spots.
Supports the moisture barrier while improving the appearance of dullness and uneven tone.
Helps minimize the look of excess pigmentation and post-blemish marks.
Curious about your ingredients?
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We’re here to helpFrom our Edmonton boutique
Discover Le Mieux Brightening Serum at Loshen & Crem, a skin-health boutique and facial studio in Edmonton, Alberta. Explore the Le Mieux collection online across Canada, or speak with our facialists about how this formula fits into the products you already use.
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