Your routine
Biologique RechercheLotion P50T
Why it fits
Biologique Recherche’s exfoliating, purifying and balancing lotion for seborrheic Skin Instants. The first step after cleansing.
Biologique Recherche Le Grand Coffret
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La Grande Crème and Le Grand Sérum together in one set, for Skin Instants showing visible signs of aging. The rich cream and the finishing serum are designed to be layered.
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Boutique details
Your Edmonton boutique.
5238 Windermere Boulevard
Edmonton AB T6W 0L9
Canada
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Selected with care.
Biologique Recherche
Le Grand Coffret
Your ritual begins with the right choice.
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The skincare focus
The most complete finish to a Biologique Recherche routine.
La Grande Crème and Le Grand Sérum together in one set, for Skin Instants showing visible signs of aging. The rich cream and the finishing serum are designed to be layered.
Explore our ingredient glossaryBiologique Recherche
The formula, explained.
The ingredients behind this formula—and what they bring to your skin.
Paeonia Albiflora (Peony) Root Extract (La Grande Crème)
A botanical extract included to help skin look plumper and more supple.
Camellia Sinensis Leaf Extract & Lepidium Sativum (Watercress) Sprout Extract (La Grande Crème)
Botanical extracts included to help even the look of skin tone.
Acetyl Hexapeptide-8 (both formulas)
A peptide included to help soften the look of expression lines.
Ingredient imagery is illustrative. Explore the full ingredient list below.
Made to work together
Pairs beautifully.
Cleanse with your milk, apply the Lotion P50 selected for your Skin Instant, then your Quintessential Serums. Apply La Grande Crème, then finish with Le Grand Sérum. For a more complete ritual, add Masque Biofixine and Crème Contour des Yeux et Lèvres Biofixine for the eye and lip area, and wear sunscreen in the morning.
Your routine
Biologique RechercheCrème Contour des Yeux et Lèvres Biofixine
Why it fits
Le Grand Coffret covers the face, neck and décolleté, and our estheticians like to round it out with Crème Contour des Yeux et Lèvres Biofixine for the eye and lip area.
Worth knowing
The finer details.
A closer look at your skin, your routine and what goes into the formula.
Biologique Recherche Le Grand Coffret
Biologique Recherche Le Grand Coffret brings together two of the brand's most luxurious formulas, La Grande Crème and Le Grand Sérum, in one set. It includes La Grande Crème (50 ml) with its spatula, and Le Grand Sérum (30 ml).
The rich cream and the finishing serum are designed to be layered: together, they help reduce the look of fine lines and wrinkles, help skin look firmer with more defined-looking contours, and leave the complexion looking more even and radiant. Their antioxidant ingredients help protect skin from environmental stressors.
Le Grand Sérum contains hazelnut protein, and both formulas contain peppermint oil. If you have a nut allergy or very reactive skin, please book a consultation with one of our estheticians before purchasing.
Why we love it
This is a beautiful ritual for anyone who wants the most complete Biologique Recherche routine for skin showing visible signs of aging. We love the way the rich cream and the finishing serum are layered as the last two steps. To round it out, our estheticians like to add Masque Biofixine and Crème Contour des Yeux et Lèvres Biofixine for the eye and lip area. And in the morning, daily sunscreen always completes it.
Benefits
- Helps visibly reduce the look of fine lines and wrinkles
- Helps skin look firmer, with more defined-looking contours
- Helps fade the look of dark spots and even the look of skin tone
- Helps the complexion look more radiant
- Antioxidant ingredients help protect skin from environmental stressors
Best for
Skin showing visible signs of aging
Use the spatula for La Grande Crème, and keep Le Grand Sérum for last: 4 to 5 drops are enough for the face, neck and décolleté.
How to use
- Cleanse with your milk, then apply the Lotion P50 selected for your Skin Instant and your Quintessential Serums.
- Apply a small amount of La Grande Crème to the entire face, neck and décolleté, morning and/or evening.
- Finish with 4 to 5 drops of Le Grand Sérum on the same areas, as the final step of your routine.
- In the morning, wear your daily sunscreen.
- Avoid contact with the eyes. For external use only.
Precautions
Full Ingredient List
Biologique Recherche La Grande Crème
WATER (AQUA), OCTYLDODECANOL, CETEARYL ALCOHOL, GLYCERYL STEARATE, BUTYLENE GLYCOL, GLYCERIN, PROPANEDIOL, ALCOHOL DENAT., UNDECANE, BUTYROSPERMUM PARKII (SHEA) BUTTER, PROPYLENE GLYCOL, CETEARETH-20, PENTAERYTHRITYL TETRASTEARATE, SORBITAN STEARATE, CERA ALBA (BEESWAX), CAMELLIA SINENSIS LEAF EXTRACT, PAEONIA ALBIFLORA ROOT EXTRACT, MIMOSA TENUIFLORA BARK EXTRACT, ONOPORDUM ACANTHIUM FLOWER/LEAF/STEM EXTRACT, VITIS VINIFERA (GRAPE) JUICE EXTRACT, JASMINUM GRANDIFLORUM (JASMINE) FLOWER EXTRACT, SAMBUCUS NIGRA FLOWER EXTRACT, TERMINALIA CATAPPA LEAF EXTRACT, SOY ISOFLAVONES, LEPIDIUM SATIVUM SPROUT EXTRACT, HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL, LACTOBACILLUS/WASABIA JAPONICA ROOT FERMENT EXTRACT, PICHIA ANOMALA EXTRACT, ACETYL HEXAPEPTIDE-8, PALMITOYL OLIGOPEPTIDE, PENTAPEPTIDE-48, PALMITOYL TETRAPEPTIDE-7, ALPHA-GLUCAN OLIGOSACCHARIDE, DECARBOXY CARNOSINE HCL, SODIUM LACTATE, TANNIC ACID, CARUM CARVI (CARAWAY) FRUIT OIL, MENTHA PIPERITA (PEPPERMINT) OIL, CETYL PALMITATE, COCOGLYCERIDES, LECITHIN, HYDROGENATED LECITHIN, MALTODEXTRIN, TOCOPHEROL, CARBOMER, TRIDECANE, POLYSORBATE 80, ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER, TRIETHANOLAMINE, PVP, DISODIUM EDTA, POLYACRYLATE CROSSPOLYMER-6, POLYSORBATE 20, T-BUTYL ALCOHOL, PHENOXYETHANOL, METHYLPROPANEDIOL, ETHYLHEXYLGLYCERIN, CAPRYLHYDROXAMIC ACID, PHENETHYL ALCOHOL, CAPRYLYL GLYCOL, SORBIC ACID, LIMONENE.
Biologique Recherche Le Grand Sérum
WATER (AQUA), PROPYLENE GLYCOL, GLYCERIN, PROPANEDIOL, MALTODEXTRIN, HYDROLYZED HAZELNUT PROTEIN, LACTOBACILLUS/WASABIA JAPONICA ROOT FERMENT EXTRACT, PENTYLENE GLYCOL, CARVONE, MENTHOL, MYRTUS COMMUNIS LEAF EXTRACT, ALLIUM CEPA (ONION) BULB EXTRACT, COMMIPHORA MYRRHA RESIN EXTRACT, HONEY EXTRACT (MEL EXTRACT), CAMELLIA SINENSIS LEAF EXTRACT, HAMAMELIS VIRGINIANA (WITCH HAZEL) BARK/LEAF EXTRACT, CENTELLA ASIATICA EXTRACT, HYPERICUM PERFORATUM FLOWER/LEAF/STEM EXTRACT, PUNICA GRANATUM PERICARP EXTRACT, HAEMATOCOCCUS PLUVIALIS EXTRACT, HYDROLYZED SOY PROTEIN, HYDROLYZED YEAST PROTEIN, YEAST EXTRACT, SACCHAROMYCES CEREVISIAE EXTRACT, BIOSACCHARIDE GUM-1, ACETYL HEXAPEPTIDE-8, NIACINAMIDE, SODIUM HYALURONATE, LACTIC ACID, SODIUM LACTATE, CITRIC ACID, ALLANTOIN, SERINE, ROYAL JELLY EXTRACT, CARUM CARVI (CARAWAY) FRUIT OIL, MENTHA PIPERITA (PEPPERMINT) OIL, ACACIA SENEGAL GUM, XANTHAN GUM, CARAMEL, HYDROGENATED STARCH HYDROLYSATE, LECITHIN, 1,2-HEXANEDIOL, TEA-LACTATE, UREA, PHENYLPROPANOL, PHENOXYETHANOL, CAPRYLYL GLYCOL, SODIUM BENZOATE, POTASSIUM SORBATE, LIMONENE.
Frequently Asked Questions
What is included in Le Grand Coffret?
La Grande Crème (50 ml), the La Grande Crème spatula and Le Grand Sérum (30 ml).
In what order do I apply them?
La Grande Crème first, after your Lotion P50 and Quintessential Serums, then 4 to 5 drops of Le Grand Sérum as the final step of your routine.
When should I use them?
Morning and/or evening. In the morning, wear your daily sunscreen.
Is there anything to know about allergies?
Le Grand Sérum contains hazelnut protein, and both formulas contain peppermint oil. If you have a nut allergy or very reactive skin, please book a consultation with one of our estheticians before purchasing.
Where can I find the full ingredient lists?
Each formula has its own ingredient list; please check the packaging, or write to info@loshen.ca and our team will help verify the most current list.
Consultation & reactions
At Loshen & Crem, we want to ensure you have the best possible experience with Biologique Recherche. Before purchasing any Biologique Recherche product, we highly recommend booking a consultation with one of our estheticians. Consultations are available virtually through Google Meet or in person at our Edmonton boutique. An appointment is required.
In the event of a reaction, Biologique Recherche requires photos of the reaction and the product, the lot number found on the product or the bottom of the box, and proof of a consultation with one of our estheticians before they can review the concern.
If you choose to purchase without a consultation and experience a reaction, we will be unable to provide a refund. Our team is always happy to answer your questions and help you select the products best suited to your skin.
Shipping
For delivery and return information, view our policy.
Biologique Recherche Le Grand Coffret brings together two of the brand's most luxurious formulas, La Grande Crème and Le Grand Sérum, in one set. It includes La Grande Crème (50 ml) with its spatula, and Le Grand Sérum (30 ml).
The rich cream and the finishing serum are designed to be layered: together, they help reduce the look of fine lines and wrinkles, help skin look firmer with more defined-looking contours, and leave the complexion looking more even and radiant. Their antioxidant ingredients help protect skin from environmental stressors.
Le Grand Sérum contains hazelnut protein, and both formulas contain peppermint oil. If you have a nut allergy or very reactive skin, please book a consultation with one of our estheticians before purchasing.
Benefits
- Helps visibly reduce the look of fine lines and wrinkles
- Helps skin look firmer, with more defined-looking contours
- Helps fade the look of dark spots and even the look of skin tone
- Helps the complexion look more radiant
- Antioxidant ingredients help protect skin from environmental stressors
How to use
- Cleanse with your milk, then apply the Lotion P50 selected for your Skin Instant and your Quintessential Serums.
- Apply a small amount of La Grande Crème to the entire face, neck and décolleté, morning and/or evening.
- Finish with 4 to 5 drops of Le Grand Sérum on the same areas, as the final step of your routine.
- In the morning, wear your daily sunscreen.
- Avoid contact with the eyes. For external use only.
Skin Reaction Policy
At Loshen & Crem, we want to ensure you have the best possible experience with Biologique Recherche. Before purchasing any Biologique Recherche product, we highly recommend booking a consultation with one of our estheticians. Consultations are available virtually through Google Meet or in person at our Edmonton boutique. An appointment is required.
In the event of a reaction, Biologique Recherche requires photos of the reaction and the product, the lot number found on the product or the bottom of the box, and proof of a consultation with one of our estheticians before they can review the concern.
If you choose to purchase without a consultation and experience a reaction, we will be unable to provide a refund. Our team is always happy to answer your questions and help you select the products best suited to your skin.
The care behind your order
From our boutique.
To your door.
A few helpful details, before your next delivery.
Track your order01 · Across Canada
A good thing, on its way.
$149+Free Regular shipping
$249+Free Priority shipping
CAD · After discounts, before taxes and shipping. Conditions and product exclusions apply.
Canada & U.S. delivery details02 · Close to home
Collect in Edmonton.
Choose pickup at checkout when available. We’ll let you know when your order is ready.
Speak with our boutique03 · A little reassurance
Here after checkout, too.
Request an eligible return within 30 days. Items must be unopened, unused and in their original packaging. Final-sale exclusions apply.
Returns & order support
Paeonia Albiflora (Peony) Root Extract (La Grande Crème)
A botanical extract included to help skin look plumper and more supple.
Camellia Sinensis Leaf Extract & Lepidium Sativum (Watercress) Sprout Extract (La Grande Crème)
Botanical extracts included to help even the look of skin tone.
Acetyl Hexapeptide-8 (both formulas)
A peptide included to help soften the look of expression lines.
Niacinamide & Sodium Hyaluronate (Le Grand Sérum)
Vitamin B3 helps skin look smoother and more even, while hyaluronic acid hydrates the upper layers of the epidermis.
Centella Asiatica & Hamamelis Virginiana (Witch Hazel) Extracts (Le Grand Sérum)
Botanical extracts that help skin feel comfortable.
Curious about your ingredients?
Explore La Matière
A little guidance. A more considered routine.
Your skin.
Our attention.
Beautiful formulas are only part of the story. Knowing what belongs in your routine makes all the difference.
Talk through your skin, the products you already use and the questions on your mind with one of our facialists.
Book your consultation Just a product question? Ask us.Personal guidance, in Edmonton or online.
The care behind your care
A place in your routine.
A team in your corner.
From your first question to your next replenishment, there’s a real person here to help.
01 Make sense of what you already use
You don’t need to start over. Bring us your current routine and we’ll help you understand where a new formula fits.
Ask our team02 Get to know your skin
Take our skin questionnaire for a thoughtful starting point, then speak with us if you’d like to explore your recommendations.
Find your starting point03 Keep the conversation going
A question about how to use it? Unsure about your next step? You’re welcome to come back to our team for guidance.
We’re here to helpFrom our Edmonton boutique
Explore Biologique Recherche.
Find your place to begin.
Discover Biologique Recherche Le Grand Coffret at Loshen & Crem, a skin-health boutique and facial studio in Edmonton, Alberta. Explore the Biologique Recherche collection online across Canada, or speak with our facialists about how this formula fits into the products you already use.
A little care, to keep.
Your ritual, beautifully noted.
The guidance you’ll want when you get home: how to use it, what to expect and when to check in. A little reminder, with your team still in reach.