Your routine
Biologique RechercheLotion P50T
Why it fits
Biologique Recherche’s exfoliating, purifying and balancing lotion for seborrheic Skin Instants. The first step after cleansing.

Skincare Boutique & Facial Institute
Skincare Boutique & Facial Institute
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Explore La Crem rewardsFirst visible signs of aging, very dry skin
A rich smoothing and firming cream for very dry skin with lines and wrinkles that is losing elasticity. It helps smooth the look of fine lines and leaves the complexion hydrated and more radiant.
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5238 Windermere Boulevard
Edmonton AB T6W 0L9
Canada
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Biologique Recherche
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The skincare focus
A rich smoothing and firming cream for very dry skin with lines and wrinkles that is losing elasticity. It helps smooth the look of fine lines and leaves the complexion hydrated and more radiant.
Explore our ingredient glossaryBiologique Recherche
The ingredients behind this formula—and what they bring to your skin.
Green Anise Extract & Walnut Extract
Smoothing ingredients, combined with the formula's botanical tensing ingredient.
Edelweiss Extract
An antioxidant ingredient.
Specific BR Oxygenating Complex
A revitalizing complex.
Ingredient imagery is illustrative. Explore the full ingredient list below.
Made to work together
Cleanse with the milk selected for your Skin Instant, then apply the Lotion P50 selected for your Skin Instant. Apply your serums, such as Sérum Élastine or Sérum Colostrum VG, then Crème Biofixine. Add sunscreen in the morning. These pairings are suggestions; your routine should be personalized to your Skin Instant.
Your routine
Biologique Recherche’s exfoliating, purifying and balancing lotion for seborrheic Skin Instants. The first step after cleansing.
Your routine
Sérum Élastine is one of the serums we suggest applying before Crème Biofixine, adding a serum step to a routine focused on the look of fine lines and suppleness.
Worth knowing
A closer look at your skin, your routine and what goes into the formula.
Biologique Recherche Crème Biofixine is a rich cream for very dry skin with lines and wrinkles that is losing elasticity. It helps smooth the look of fine lines and wrinkles, helps skin look firmer and more toned, and leaves the complexion hydrated and more radiant.
It is especially well suited to the eye and mouth areas and to expression lines, and is recommended for all skin types showing the first visible signs of aging, as well as devitalized Skin Instants.
The formula combines a botanical tensing ingredient with anise: green anise and walnut extracts for smoothing, edelweiss extract as an antioxidant, a specific BR Oxygenating Complex for revitalizing, and grape seed oil for moisture.
Crème Biofixine is the cream we reach for when the first expression lines start to show around the eyes and mouth. We love that it is rich and comforting for very dry skin, while helping the skin look firmer and smoother. It can be used in the morning, but we especially like it in the evening. Layered over a serum such as Sérum Élastine or Sérum Colostrum VG, it completes a routine focused on fine lines and suppleness.
First visible signs of aging, very dry skin
Make it your evening cream, and spend an extra moment smoothing it over expression lines around the eyes and mouth.
WATER (AQUA), STEARIC ACID, GLYCERIN, PROPYLENE GLYCOL, PALMITIC ACID, VITIS VINIFERA (GRAPE) SEED OIL, CETYL ALCOHOL, PENTYLENE GLYCOL, POLYSORBATE 40, HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL, BUTYLENE GLYCOL, PEG-2 STEARATE, TEA-STEARATE, JUGLANS REGIA (WALNUT) SEED EXTRACT, LEONTOPODIUM ALPINUM FLOWER/LEAF EXTRACT, NASTURTIUM OFFICINALE EXTRACT, PIMPINELLA ANISUM (ANISE) FRUIT EXTRACT, ACETYL HEXAPEPTIDE-8, PERFLUORODECALIN, POLYPERFLUOROMETHYLISOPROPYL ETHER, POLOXAMER 188, CAPRYLYL GLYCOL, P-ANISIC ACID, PHENOXYETHANOL, BENZOIC ACID, SODIUM BENZOATE, SODIUM METABISULFITE, SORBIC ACID.
All skin types showing the first visible signs of aging, and devitalized Skin Instants. It is a rich cream, especially for very dry skin with lines and wrinkles that is losing elasticity.
Yes. It is especially well suited to the eye and mouth areas and to expression lines.
It can be used in the morning, but we especially like it in the evening.
Apply your serums first, such as Sérum Élastine or Sérum Colostrum VG, and, if you use one, a finishing serum such as Sérum Grand Millésime or Le Grand Sérum.
It helps reduce the look of fine lines and wrinkles, including crow's feet, forehead lines and smile lines.
Yes. The formula contains ingredients derived from walnut. If you have a nut allergy, please book a consultation with one of our estheticians before purchasing.
At Loshen & Crem, we want to ensure you have the best possible experience with Biologique Recherche. Before purchasing any Biologique Recherche product, we highly recommend booking a consultation with one of our estheticians. Consultations are available virtually through Google Meet or in person at our Edmonton boutique. An appointment is required.
In the event of a reaction, Biologique Recherche requires photos of the reaction and the product, the lot number found on the product or the bottom of the box, and proof of a consultation with one of our estheticians before they can review the concern.
If you choose to purchase without a consultation and experience a reaction, we will be unable to provide a refund. Our team is always happy to answer your questions and help you select the products best suited to your skin.
For delivery and return information, view our policy.
Biologique Recherche Crème Biofixine is a rich cream for very dry skin with lines and wrinkles that is losing elasticity. It helps smooth the look of fine lines and wrinkles, helps skin look firmer and more toned, and leaves the complexion hydrated and more radiant.
It is especially well suited to the eye and mouth areas and to expression lines, and is recommended for all skin types showing the first visible signs of aging, as well as devitalized Skin Instants.
The formula combines a botanical tensing ingredient with anise: green anise and walnut extracts for smoothing, edelweiss extract as an antioxidant, a specific BR Oxygenating Complex for revitalizing, and grape seed oil for moisture.
WATER (AQUA), STEARIC ACID, GLYCERIN, PROPYLENE GLYCOL, PALMITIC ACID, VITIS VINIFERA (GRAPE) SEED OIL, CETYL ALCOHOL, PENTYLENE GLYCOL, POLYSORBATE 40, HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL, BUTYLENE GLYCOL, PEG-2 STEARATE, TEA-STEARATE, JUGLANS REGIA (WALNUT) SEED EXTRACT, LEONTOPODIUM ALPINUM FLOWER/LEAF EXTRACT, NASTURTIUM OFFICINALE EXTRACT, PIMPINELLA ANISUM (ANISE) FRUIT EXTRACT, ACETYL HEXAPEPTIDE-8, PERFLUORODECALIN, POLYPERFLUOROMETHYLISOPROPYL ETHER, POLOXAMER 188, CAPRYLYL GLYCOL, P-ANISIC ACID, PHENOXYETHANOL, BENZOIC ACID, SODIUM BENZOATE, SODIUM METABISULFITE, SORBIC ACID.
At Loshen & Crem, we want to ensure you have the best possible experience with Biologique Recherche. Before purchasing any Biologique Recherche product, we highly recommend booking a consultation with one of our estheticians. Consultations are available virtually through Google Meet or in person at our Edmonton boutique. An appointment is required.
In the event of a reaction, Biologique Recherche requires photos of the reaction and the product, the lot number found on the product or the bottom of the box, and proof of a consultation with one of our estheticians before they can review the concern.
If you choose to purchase without a consultation and experience a reaction, we will be unable to provide a refund. Our team is always happy to answer your questions and help you select the products best suited to your skin.
The care behind your order
A few helpful details, before your next delivery.
Track your order01 · Across Canada
$149+Free Regular shipping
$249+Free Priority shipping
CAD · After discounts, before taxes and shipping. Conditions and product exclusions apply.
Canada & U.S. delivery details02 · Close to home
Choose pickup at checkout when available. We’ll let you know when your order is ready.
Speak with our boutique03 · A little reassurance
Request an eligible return within 30 days. Items must be unopened, unused and in their original packaging. Final-sale exclusions apply.
Returns & order support
Smoothing ingredients, combined with the formula's botanical tensing ingredient.
An antioxidant ingredient.
A revitalizing complex.
A moisturizing ingredient.
Curious about your ingredients?
Explore La Matière
A little guidance. A more considered routine.
Beautiful formulas are only part of the story. Knowing what belongs in your routine makes all the difference.
Talk through your skin, the products you already use and the questions on your mind with one of our facialists.
Book your consultation Just a product question? Ask us.The care behind your care
From your first question to your next replenishment, there’s a real person here to help.
You don’t need to start over. Bring us your current routine and we’ll help you understand where a new formula fits.
Ask our teamTake our skin questionnaire for a thoughtful starting point, then speak with us if you’d like to explore your recommendations.
Find your starting pointA question about how to use it? Unsure about your next step? You’re welcome to come back to our team for guidance.
We’re here to helpFrom our Edmonton boutique
Discover Biologique Recherche Crème Biofixine at Loshen & Crem, a skin-health boutique and facial studio in Edmonton, Alberta. Explore the Biologique Recherche collection online across Canada, or speak with our facialists about how this formula fits into the products you already use.
A little care, to keep.
The guidance you’ll want when you get home: how to use it, what to expect and when to check in. A little reminder, with your team still in reach.