Your routine
BiodermaSensibio H2O Micellar Water
Why it fits
A gentle micellar cleanser and makeup remover, the first step of your routine.
Bioderma Sensibio Defensive Serum
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Explore La Crem rewardsSensitive, tired-looking skin
A lightweight, milky soothing serum for sensitive skin that feels uncomfortable, dehydrated or tired. Carnosine, a peptide, red sage extract and hyaluronic acid help soothe, hydrate and revive the look of radiance.
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Shipping, on usRegular $149+ · Priority $249+ CAD
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Bioderma
Sensibio Defensive Serum
Your ritual begins with the right choice.
$44.99 CAD
Taxes calculated at checkout.
The skincare focus
Calm and radiance for reactive skin.
A lightweight, milky soothing serum for sensitive skin that feels uncomfortable, dehydrated or tired. Carnosine, a peptide, red sage extract and hyaluronic acid help soothe, hydrate and revive the look of radiance.
Explore our ingredient glossaryBioderma
The formula, explained.
The ingredients behind this formula—and what they bring to your skin.
Carnosine
An antioxidant that helps protect the skin from external stressors that contribute to dryness and visible aging.
Palmitoyl Tetrapeptide-10
A peptide that helps support the skin’s moisture barrier and its resilience.
Hydrolyzed Hyaluronic Acid
Helps provide lightweight hydration for smoother, plumper-looking skin.
Ingredient imagery is illustrative. Explore the full ingredient list below.
Made to work together
Pairs beautifully.
Cleanse gently with Sensibio H2O Micellar Water, apply the serum, then seal it in with Sensibio Defensive.
Your routine
BiodermaSensibio Eye+
Why it fits
A targeted eye care applied after cleansing and serum, before your moisturizer.
Worth knowing
The finer details.
A closer look at your skin, your routine and what goes into the formula.
Bioderma Sensibio Defensive Serum
Bioderma Sensibio Defensive Serum is a light, milky serum for sensitive and sensitized skin that feels uncomfortable, dehydrated or tired from daily external stressors.
Carnosine and vitamin E (tocopherol) offer antioxidant support, palmitoyl tetrapeptide-10 helps support the moisture barrier, and red sage root extract helps soothe the look of reactivity. Hydrolyzed hyaluronic acid and glycerin bring lightweight hydration.
Fragrance-free and very comfortable, it layers easily under your moisturizer and leaves the skin calm, hydrated and fresh-looking, with fine lines looking softer over time.
Why we love it
Sensitive skin can look dull and tired as well as reactive, and most radiance serums are too much for it. This one is gentle enough for easily irritated skin, yet it still brings back a fresher look. We like how quickly it sinks in, so it never makes a routine feel heavy.
Benefits
- Helps soothe sensitive skin
- Provides lasting hydration
- Helps soften the look of fine lines
- Helps revive the look of radiance
- Supports the skin’s moisture barrier
- Lightweight, milky, fragrance-free texture
Best for
Sensitive, tired-looking skin
Apply to slightly damp skin and let it settle for a minute before your moisturizer.
How to use
- Morning and evening.
- Apply to clean skin on the face and neck.
- Follow with your moisturizer.
- In the morning, finish with a daily sunscreen.
Full Ingredient List
Aqua/Water/Eau, Glycerin, Butylene Glycol, C15-19 Alkane, Squalane, Cellulose, C20-22 Alkyl Phosphate, C20-22 Alcohols, Pentylene Glycol, 1,2-Hexanediol, Caprylyl Glycol, Carnosine, Polyacrylate Crosspolymer-6, Maltodextrin, Xanthan Gum, Mannitol, Xylitol, Tocopherol, Salvia Miltiorrhiza Root Extract, Rhamnose, Biosaccharide Gum-1, Citric Acid, Glycine Soja (Soybean) Oil, Hydrolyzed Hyaluronic Acid, Sodium Hydroxide, Palmitoyl Tetrapeptide-10. [BI 2010]
Frequently Asked Questions
Is the serum fragrance-free?
Yes. It is fragrance-free and made for sensitive skin.
Do I still need a moisturizer?
Yes. Follow with your moisturizer; Sensibio Defensive is the natural partner.
Can I use it morning and evening?
Yes. Apply it twice a day to clean skin, before your moisturizer.
Does it suit very reactive skin?
It is formulated for sensitive and sensitized skin. As with any new product, start slowly and watch how your skin responds.
Shipping & returns
For delivery and return information, view our policy.
A lightweight, milky soothing serum for sensitive and sensitized skin that feels uncomfortable, dehydrated or tired from daily external aggressions. Sensibio Defensive Serum helps soothe the skin, support its moisture barrier and revive the look of radiance, while helping soften the appearance of fine lines over time. Fragrance-free and very comfortable, it layers easily under your moisturizer and leaves the skin calm, hydrated and fresh-looking.
Benefits:
- Helps soothe sensitive skin
- Provides lasting hydration
- Helps reduce the appearance of fine lines and wrinkles
- Helps revive the look of radiance
- Supports the skin’s moisture barrier
- Lightweight, milky, fragrance-free texture
How to Use:
- Apply morning and evening to the face and neck
- Use on clean skin
- Follow with your moisturizer
- Follow with sunscreen in the morning
Loshen & Crem’s Recommendation:
The serum we reach for when sensitive skin looks dull and tired as well as reactive. Seal it in with Sensibio Defensive for a simple, complete soothing routine.
Ingredients:
Key Ingredients:
- Carnosine: An antioxidant that helps protect the skin from external stressors that contribute to dryness and visible aging.
- Palmitoyl Tetrapeptide-10: Helps support the skin’s moisture barrier and its resilience.
- Salvia Miltiorrhiza Root Extract: Helps soothe the skin and reduce the look of reactivity.
- Hydrolyzed Hyaluronic Acid: Helps provide lightweight hydration for smoother, plumper-looking skin.
Full Ingredients List:
Aqua/Water/Eau, Glycerin, Butylene Glycol, C15-19 Alkane, Squalane, Cellulose, C20-22 Alkyl Phosphate, C20-22 Alcohols, Pentylene Glycol, 1,2-Hexanediol, Caprylyl Glycol, Carnosine, Polyacrylate Crosspolymer-6, Maltodextrin, Xanthan Gum, Mannitol, Xylitol, Tocopherol, Salvia Miltiorrhiza Root Extract, Rhamnose, Biosaccharide Gum-1, Citric Acid, Glycine Soja (Soybean) Oil, Hydrolyzed Hyaluronic Acid, Sodium Hydroxide, Palmitoyl Tetrapeptide-10. [BI 2010]
The care behind your order
From our boutique.
To your door.
A few helpful details, before your next delivery.
Track your order01 · Across Canada
A good thing, on its way.
$149+Free Regular shipping
$249+Free Priority shipping
CAD · After discounts, before taxes and shipping. Conditions and product exclusions apply.
Canada & U.S. delivery details02 · Close to home
Collect in Edmonton.
Choose pickup at checkout when available. We’ll let you know when your order is ready.
Speak with our boutique03 · A little reassurance
Here after checkout, too.
Request an eligible return within 30 days. Items must be unopened, unused and in their original packaging. Final-sale exclusions apply.
Returns & order support
Carnosine
An antioxidant that helps protect the skin from external stressors that contribute to dryness and visible aging.
Palmitoyl Tetrapeptide-10
A peptide that helps support the skin’s moisture barrier and its resilience.
Hydrolyzed Hyaluronic Acid
Helps provide lightweight hydration for smoother, plumper-looking skin.
Salvia Miltiorrhiza (Red Sage) Root Extract
Helps soothe the skin and reduce the look of reactivity.
Curious about your ingredients?
Explore La Matière
A little guidance. A more considered routine.
Your skin.
Our attention.
Beautiful formulas are only part of the story. Knowing what belongs in your routine makes all the difference.
Talk through your skin, the products you already use and the questions on your mind with one of our facialists.
Book a consultation Just a product question? Ask us.Personal guidance, in Edmonton or online.
The care behind your care
A place in your routine.
A team in your corner.
From your first question to your next replenishment, there’s a real person here to help.
01 Make sense of what you already use
You don’t need to start over. Bring us your current routine and we’ll help you understand where a new formula fits.
Ask our team02 Get to know your skin
Take our skin questionnaire for a thoughtful starting point, then speak with us if you’d like to explore your recommendations.
Find your starting point03 Keep the conversation going
A question about how to use it? Unsure about your next step? You’re welcome to come back to our team for guidance.
We’re here to helpFrom our Edmonton boutique
Explore Bioderma.
Find your place to begin.
Discover Bioderma Sensibio Defensive Serum at Loshen & Crem, a skin-health boutique and facial studio in Edmonton, Alberta. Explore the Bioderma collection online across Canada, or speak with our facialists about how this formula fits into the products you already use.
A little care, to keep.
Your ritual, beautifully noted.
The guidance you’ll want when you get home: how to use it, what to expect and when to check in. A little reminder, with your team still in reach.