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Le Mieux24 Hr. Age Defying Cream
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A Loshen & Crem bestseller for lasting moisture, barrier support and smoother, firmer-looking skin

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Explore La Crem rewardsA rich Hya10+ and multi-peptide serum for visibly plumper, firmer and more resilient-looking skin
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5238 Windermere Boulevard
Edmonton AB T6W 0L9
Canada
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Le Mieux
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$135.00 CAD
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The skincare focus
A rich Hya10+ and multi-peptide serum for visibly plumper, firmer and more resilient-looking skin
Explore our ingredient glossaryLe Mieux
The ingredients behind this formula—and what they bring to your skin.
Hya10+ Complex
Provides multi-dimensional hydration and supports visible plumpness.
Galactomyces Ferment Filtrate
Helps condition the skin and supports a smoother, more radiant appearance.
Acetyl Tetrapeptide-2
Supports firmer and more elastic-looking skin.
Ingredient imagery is illustrative. Explore the full ingredient list below.
Made to work together
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Your routine
A Loshen & Crem bestseller for lasting moisture, barrier support and smoother, firmer-looking skin
Your routine
A nourishing peptide cleanser for soft, supple and comfortably clean skin
Worth knowing
A closer look at your skin, your routine and what goes into the formula.
A rich Hya10+ and multi-peptide serum for visibly plumper, firmer and more resilient-looking skin
Le Mieux Collagen Peptide Serum is a creamy, moisture-intensive treatment developed for visible loss of firmness, elasticity and facial definition. The updated formula combines six peptides with the Hya10+ Complex—10 distinct forms of hyaluronic acid—to replenish hydration and help dry, depleted skin appear smoother, fuller and more supple.
Galactomyces ferment filtrate forms the antioxidant-rich base, while ceramides, shea butter, rice bran oil and plant sterols support the skin’s moisture barrier. Apple fruit cell culture extract, green tea derivatives, vitamin E and superoxide dismutase complement the formula with conditioning and antioxidant benefits.
Despite its name, Collagen Peptide Serum does not contain topical collagen. Its peptides and supporting ingredients are intended to promote the appearance of firmer, more elastic skin; they should not be presented as physically lifting facial tissue or guaranteeing new collagen production.
Galactomyces Ferment Filtrate, Sodium Hyaluronate, Oryza Sativa (Rice) Bran Water, Hyaluronic Acid, Zinc Hydrolyzed Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Sodium Hyaluronate Dimethylsilanol, Sodium Hyaluronate Crosspolymer, C12-13 Alkyl Glyceryl Hydrolyzed Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Ascorbyl Propyl Hyaluronate, Acetyl Tetrapeptide-2, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-5, Acetyl Octapeptide-3, Epigallocatechin Gallatyl Glucoside, Camellia Sinensis Leaf Extract, Hydrolyzed Avocado Protein, Glycine Soja (Soybean) Seed Extract, Teprenone, Oryza Sativa (Rice) Bran Oil, Caprylic/Capric Triglyceride, Ceramide NS, Ceramide NP, Tocotrienols, Brassica Campestris (Rapeseed) Sterols, Butyrospermum Parkii (Shea) Butter, Sodium Palmitoyl Proline, Nymphaea Alba Flower Extract, Malus Domestica Fruit Cell Culture Extract, Dipalmitoyl Hydroxyproline, Sodium Carboxymethyl Beta-Glucan, Superoxide Dismutase, Glucosamine HCl, Laminaria Digitata Extract, Cellulose Gum, Isomalt, Saccharomyces Cerevisiae Extract, Sodium PCA, Enteromorpha Compressa Extract, Urea, Retinyl Palmitate, Tocopherol, Caprylyl Glycol, Ethylhexylglycerin, Undecylenoyl Glycine, Capryloyl Glycine.
Ingredient lists may change. Always refer to the product packaging for the most current ingredient list, particularly if you have allergies or sensitivities. Contact info@loshen.ca if you need help reviewing the formula before purchasing.
For delivery and return information, view our policy.
A rich Hya10+ and multi-peptide serum for visibly plumper, firmer and more resilient-looking skin
Le Mieux Collagen Peptide Serum is a creamy, moisture-intensive treatment developed for visible loss of firmness, elasticity and facial definition. The updated formula combines six peptides with the Hya10+ Complex—10 distinct forms of hyaluronic acid—to replenish hydration and help dry, depleted skin appear smoother, fuller and more supple.
Galactomyces ferment filtrate forms the antioxidant-rich base, while ceramides, shea butter, rice bran oil and plant sterols support the skin’s moisture barrier. Apple fruit cell culture extract, green tea derivatives, vitamin E and superoxide dismutase complement the formula with conditioning and antioxidant benefits.
Despite its name, Collagen Peptide Serum does not contain topical collagen. Its peptides and supporting ingredients are intended to promote the appearance of firmer, more elastic skin; they should not be presented as physically lifting facial tissue or guaranteeing new collagen production.
Collagen Peptide Serum is particularly well suited to:
Very oily or highly congestion-prone skin may find the rich combination of shea butter, rice bran oil and emollients heavier than a conventional gel serum. Individual tolerance varies.
Collagen Peptide Serum combines the concentrated feel of a serum with some of the nourishing components more commonly associated with a moisturizer.
Rather than relying on one peptide or one form of hyaluronic acid, it pairs six peptides with 10 forms of hyaluronic acid, ceramides, antioxidants, fermented ingredients and moisture-supporting lipids.
Use morning and night.
After cleansing and toning, gently pat one to two pumps onto the face and neck. Apply after lightweight, water-based essences or serums and before moisturizer.
One pump may be sufficient for the face. Use a second pump when extending the treatment to the neck and décolleté or when the skin requires additional nourishment.
If your skin is sensitive or unfamiliar with vitamin A derivatives, begin once daily or every other evening and increase gradually if the skin remains comfortable.
Follow with broad-spectrum sunscreen every morning.
Collagen Peptide Serum is an excellent choice when the skin looks less firm but also feels dry, tight or depleted. Its creamy texture makes it more nourishing than Le Mieux Hyaluronic Serum or TGF-β Booster.
Apply it while the skin is still slightly damp from toner or essence, then seal it in with moisturizer. Dry and mature skin may enjoy it morning and night, while combination skin may prefer it in the evening or during colder, drier seasons.
More is not better with this formula. Begin with one pump and allow it to settle before applying your next step. Using too many rich layers can create pilling without improving results.
Because the formula contains retinyl palmitate, we would not immediately combine it with a separate retinol or strong retinoid in the same routine. Alternate evenings at first and monitor for dryness, peeling or sensitivity.
Do not place Collagen Peptide Serum inside the Le Mieux Ionized Oxygen Infuser. Le Mieux specifically lists it as incompatible with that device. Apply the serum directly to the skin by hand.
Because Collagen Peptide Serum already combines humectants, peptides, ceramides and emollients, an elaborate collection of additional serums is rarely necessary.
These treatments overlap in hydration benefits but serve different priorities.
Collagen Peptide Serum can be paired with a moisturizer, but most clients do not need several peptide serums in the same routine.
Peptides are short chains of amino acids used in skincare to support the appearance of firmness, elasticity, texture and wrinkles. Different peptides have different intended cosmetic functions, which is why Collagen Peptide Serum combines several rather than relying on only one.
The presence of peptides does not mean the serum physically replaces lost collagen or performs a structural facial lift. Hydration can create an immediate plumping effect, while longer-term improvements in firmness and lines require consistent use.
The manufacturer’s current public product page does not provide a finished-product clinical trial establishing a precise percentage of collagen increase. Claims should therefore remain focused on visible cosmetic improvement.
The formula contains 10 forms of hyaluronic acid:
These ingredients have different structures and skin-conditioning properties. Together, they support moisture retention, softness and visible surface plumping.
Claims that individual hyaluronic acid forms penetrate every layer of the skin or create permanent volume would be an overstatement. This is topical hydration—not an injectable filler.
The ingredient described as apple stem cells is listed as Malus Domestica Fruit Cell Culture Extract.
This is a plant-derived cell culture extract used for antioxidant and skin-conditioning benefits. Plant cells do not transform into human skin cells, regenerate human stem cells or replace lost tissue.
Its role is best understood as part of the formula’s broader antioxidant and conditioning system.
Collagen Peptide Serum contains retinyl palmitate, a vitamin A ester. It is not the same ingredient as retinol and this formula is not positioned as a dedicated retinoid treatment.
Retinyl palmitate generally requires additional conversion steps within the skin before reaching retinoic acid, making it less direct than retinol. Its concentration in this formula is not disclosed, so it should not be compared numerically with a retinol serum.
Sensitive skin should still introduce the formula gradually, particularly when exfoliating acids, prescription retinoids or other vitamin A products are already part of the routine.
Full Ingredient List:
Galactomyces Ferment Filtrate, Sodium Hyaluronate, Oryza Sativa (Rice) Bran Water, Hyaluronic Acid, Zinc Hydrolyzed Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Sodium Hyaluronate Dimethylsilanol, Sodium Hyaluronate Crosspolymer, C12-13 Alkyl Glyceryl Hydrolyzed Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Ascorbyl Propyl Hyaluronate, Acetyl Tetrapeptide-2, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-5, Acetyl Octapeptide-3, Epigallocatechin Gallatyl Glucoside, Camellia Sinensis Leaf Extract, Hydrolyzed Avocado Protein, Glycine Soja (Soybean) Seed Extract, Teprenone, Oryza Sativa (Rice) Bran Oil, Caprylic/Capric Triglyceride, Ceramide NS, Ceramide NP, Tocotrienols, Brassica Campestris (Rapeseed) Sterols, Butyrospermum Parkii (Shea) Butter, Sodium Palmitoyl Proline, Nymphaea Alba Flower Extract, Malus Domestica Fruit Cell Culture Extract, Dipalmitoyl Hydroxyproline, Sodium Carboxymethyl Beta-Glucan, Superoxide Dismutase, Glucosamine HCl, Laminaria Digitata Extract, Cellulose Gum, Isomalt, Saccharomyces Cerevisiae Extract, Sodium PCA, Enteromorpha Compressa Extract, Urea, Retinyl Palmitate, Tocopherol, Caprylyl Glycol, Ethylhexylglycerin, Undecylenoyl Glycine, Capryloyl Glycine.
Ingredient lists may change. Always refer to the product packaging for the most current ingredient list, particularly if you have allergies or sensitivities. Contact info@loshen.ca if you need help reviewing the formula before purchasing.
No collagen appears in the published ingredient list. The product name refers to its multi-peptide complex and its intended support for firmer, more elastic-looking skin.
Several peptides in the formula are used to support the appearance of firmness and wrinkles. However, the current public product page does not provide finished-product clinical data proving a specific increase in human collagen production.
It can help skin appear plumper, smoother and firmer through hydration, conditioning and continued peptide use. It cannot physically reposition sagging tissue or reproduce the results of a medical procedure.
Hydration and visible plumpness may be noticeable soon after application. Changes in the appearance of firmness, elasticity and wrinkles require consistent use and vary between individuals. Le Mieux does not publish a guaranteed treatment timeline on the current product page.
It is classified as a serum, but its creamy texture contains ceramides, shea butter, rice bran oil and other emollients. Dry skin should generally follow with moisturizer, while some combination skin may find it sufficiently nourishing beneath sunscreen during warmer weather.
It is best suited to normal, dry, mature or dehydrated skin. Combination skin may prefer it at night. Very oily or highly congestion-prone skin should introduce it cautiously because of its rich texture.
The published formula contains no added fragrance or essential oils, but it does contain multiple peptides, ferments, botanical ingredients and retinyl palmitate. Sensitive skin should patch test and introduce it gradually.
No parfum, fragrance or essential oils appear in the published ingredient list. Naturally occurring ingredient aromas may still be present.
It does not contain retinol, but it does contain retinyl palmitate, a different and generally milder vitamin A ester.
No. Retinyl palmitate is part of the formula, but Collagen Peptide Serum is primarily positioned as a hydrating, peptide-rich firming serum rather than a dedicated retinoid treatment.
Potentially, but the formula already contains retinyl palmitate. Begin by alternating evenings with a separate retinol or prescription retinoid rather than layering them immediately. Reduce frequency if dryness or irritation develops.
Yes, but sensitive skin may prefer acids and Collagen Peptide Serum on separate evenings. Avoid combining several active products when the skin is already dry, peeling or irritated.
Yes. It can be layered after a lightweight vitamin C serum if the skin tolerates the combination. Collagen Peptide Serum also contains antioxidant ingredients and vitamin C–related derivatives within its own formula.
Yes. Le Mieux directs the serum for morning and evening use. Apply broad-spectrum sunscreen as the final step of the morning routine.
Avoid applying it directly to the eyelids or too close to the eyes. Use a dedicated eye product for the immediate eye contour.
No. Le Mieux specifically identifies Collagen Peptide Serum as incompatible with the Ionized Oxygen Infuser. Apply it directly to the skin by hand.
Because Collagen Peptide Serum has a creamy, emollient-rich texture, Loshen & Crem prefers applying it by hand. A lighter water-based serum generally provides more comfortable glide for the Skin Perfecter’s serum-application technique.
Pilling can occur when too much product is used or several film-forming formulas are layered too quickly. Reduce the application to one pump, pat rather than rub and allow each layer to settle before continuing.
Potentially, but the rich formula contains shea butter, rice bran oil and several emollients. These ingredients are not automatically pore-clogging, but individual tolerance varies. The serum is not an acne treatment.
No. Malus Domestica Fruit Cell Culture Extract is a plant-derived cosmetic ingredient. It does not contain human stem cells and cannot become human skin tissue.
The formula contains retinyl palmitate, a vitamin A ester. Le Mieux’s published FAQ distinguishes it from retinol and does not identify retinyl palmitate as contraindicated; however, professional guidance regarding vitamin A derivatives during pregnancy can vary. Consult your physician or qualified healthcare provider before use.
The care behind your order
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Track your order01 · Across Canada
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Speak with our boutique03 · Care you can count on
Request an eligible return within 30 days. Items must be unopened, unused and in their original packaging. Final-sale exclusions apply.
Returns & order support
Provides multi-dimensional hydration and supports visible plumpness.
Helps condition the skin and supports a smoother, more radiant appearance.
Supports firmer and more elastic-looking skin.
Help improve the appearance of resilience, texture and fine lines.
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We’re here to helpFrom our Edmonton boutique
Discover Le Mieux Collagen Peptide Serum at Loshen & Crem, a skin-health boutique and facial studio in Edmonton, Alberta. Explore the Le Mieux collection online across Canada, or speak with our facialists about how this formula fits into the products you already use.
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