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Le Mieux24 Hr. Age Defying Cream
Why it fits
A Loshen & Crem bestseller for lasting moisture, barrier support and smoother, firmer-looking skin

Skincare Boutique & Facial Institute
Skincare Boutique & Facial Institute
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Explore La Crem rewardsDissolving microneedle patches with peptides and hyaluronic acid to smooth the look of expression lines
Discover the formula & ingredientsPickup in Edmonton
Usually ready in 24 hours
5238 Windermere Boulevard
Edmonton AB T6W 0L9
Canada
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Le Mieux
Your ritual begins with the right choice.
$14.00 CAD
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The skincare focus
Dissolving microneedle patches with peptides and hyaluronic acid to smooth the look of expression lines
Explore our ingredient glossaryLe Mieux
The ingredients behind this formula—and what they bring to your skin.
Hyaluronic Acid
Attracts moisture to plump the look of fine lines.
Acetyl Hexapeptide-8
A peptide that helps soften the look of expression lines.
sh-Polypeptide-1, sh-Oligopeptide-1 and sh-Oligopeptide-2
Lab-produced peptides that support smoother-looking skin.
Ingredient imagery is illustrative. Explore the full ingredient list below.
Made to work together
Explore another step in your face-care routine.
Your routine
A Loshen & Crem bestseller for lasting moisture, barrier support and smoother, firmer-looking skin
Your routine
A nourishing peptide cleanser for soft, supple and comfortably clean skin
Worth knowing
A closer look at your skin, your routine and what goes into the formula.
Dissolving microneedle patches with peptides and hyaluronic acid to smooth the look of expression lines
Le Mieux Boto-Needle Patches are targeted treatment patches lined with tiny dissolvable microneedles. Once applied, the microneedles dissolve at the skin’s surface and release peptides, hyaluronic acid, niacinamide and ceramides directly where expression lines form. The treated area looks visibly smoother, more hydrated and plumper.
Two formats are available: the Frown Line Patch for the area between the brows, and the Line Erase Eye Mask for the under-eye and crow’s feet area. Results are cosmetic and temporary, and the patches are not a substitute for injectable treatments.
Oryza Sativa Bran Water, Hyaluronic Acid, Water, sh-Polypeptide-1, Niacinamide, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Glutathione, Ceramide EOP, Ceramide NS, Ceramide NP, Phospholipids, sh-Oligopeptide-1, sh-Oligopeptide-2, Acetyl Hexapeptide-8, Caprylyl Glycol, Ethylhexylglycerin, Undecylenoyl Glycine, Capryloyl Glycine.
Ingredient lists may change. Always refer to the product packaging for the most current ingredient list, particularly if you have allergies or sensitivities. Contact info@loshen.ca if you need help reviewing the formula before purchasing.
For delivery and return information, view our policy.
Dissolving microneedle patches with peptides and hyaluronic acid to smooth the look of expression lines
Le Mieux Boto-Needle Patches are targeted treatment patches lined with tiny dissolvable microneedles. Once applied, the microneedles dissolve at the skin’s surface and release peptides, hyaluronic acid, niacinamide and ceramides directly where expression lines form. The treated area looks visibly smoother, more hydrated and plumper.
Two formats are available: the Frown Line Patch for the area between the brows, and the Line Erase Eye Mask for the under-eye and crow’s feet area. Results are cosmetic and temporary, and the patches are not a substitute for injectable treatments.
Do not apply to broken, irritated or recently treated skin.
We love these patches the night before an event. Apply them before bed over a thin layer of Hyaluronic Serum and wake up to smoother, more rested-looking lines. A slight tingling when the microneedles make contact is normal; persistent stinging or irritation is not, so remove the patch if that happens.
Full Ingredient List:
Oryza Sativa Bran Water, Hyaluronic Acid, Water, sh-Polypeptide-1, Niacinamide, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Glutathione, Ceramide EOP, Ceramide NS, Ceramide NP, Phospholipids, sh-Oligopeptide-1, sh-Oligopeptide-2, Acetyl Hexapeptide-8, Caprylyl Glycol, Ethylhexylglycerin, Undecylenoyl Glycine, Capryloyl Glycine.
Ingredient lists may change. Always refer to the product packaging for the most current ingredient list, particularly if you have allergies or sensitivities. Contact info@loshen.ca if you need help reviewing the formula before purchasing.
Most people feel only a slight prickle when applying the patch. Remove it if you experience persistent stinging or discomfort.
No. The patches hydrate and smooth the look of lines temporarily. They do not replace injectable treatments.
No. Each patch is for one application.
No fragrance or parfum is listed in the current ingredient list.
The care behind your order
A few helpful details, before your next delivery.
Track your order01 · Across Canada
$149+Free Regular shipping
$249+Free Priority shipping
CAD · After discounts, before taxes and shipping. Conditions and product exclusions apply.
Canada & U.S. delivery details02 · Close to home
Choose pickup at checkout when available. We’ll let you know when your order is ready.
Speak with our boutique03 · Care you can count on
Request an eligible return within 30 days. Items must be unopened, unused and in their original packaging. Final-sale exclusions apply.
Returns & order support
Attracts moisture to plump the look of fine lines.
A peptide that helps soften the look of expression lines.
Lab-produced peptides that support smoother-looking skin.
Supports the skin barrier and an even-looking complexion.
Curious about your ingredients?
Explore La Matière
Expert guidance. A considered routine.
Beautiful formulas are only part of the story. Knowing what belongs in your routine makes all the difference.
Talk through your skin, the products you already use and the questions on your mind with one of our facialists.
Book a consultation Just a product question? Ask us.The care behind your care
From your first question to your next replenishment, there’s a real person here to help.
You don’t need to start over. Bring us your current routine and we’ll help you understand where a new formula fits.
Ask our teamTake our skin questionnaire for a thoughtful starting point, then speak with us if you’d like to explore your recommendations.
Find your starting pointA question about how to use it? Unsure about your next step? You’re welcome to come back to our team for guidance.
We’re here to helpFrom our Edmonton boutique
Discover Le Mieux Boto-Needle Patches at Loshen & Crem, a skin-health boutique and facial studio in Edmonton, Alberta. Explore the Le Mieux collection online across Canada, or speak with our facialists about how this formula fits into the products you already use.
Care, to keep.
The guidance you’ll want when you get home: how to use it, what to expect and when to check in. Your reminder, with your team still in reach.
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