

Serum A-Glyca
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A.G.E. PROTECTION SERUM
Biologique Recherche Sérum A-Glyca is a targeted anti-glycation serum designed for skin beginning to show the first visible signs of aging.
Its formula focuses specifically on glycation — a biological process in which excess glucose can bind to structural proteins within the skin, including collagen and elastin. Over time, this process can affect the flexibility and mechanical properties of these proteins, contributing to wrinkles, reduced suppleness and visible changes in skin quality.
Sérum A-Glyca helps protect the skin against the glycation phenomenon while supporting a smoother, more supple and radiant-looking complexion.
It is particularly interesting for anyone wanting to take a more preventative approach to preserving the skin's structural quality as the first signs of aging begin to appear.
Skin Instant:
Recommended for Skin Instants showing the first visible signs of aging.
Particularly suited to skin experiencing:
- Early fine lines and wrinkles
- Reduced suppleness
- Changes in skin firmness
- A dull or tired-looking complexion
- Skin that no longer feels as flexible as it once did
- Early visible changes in overall skin quality
- A desire to take a preventative approach to glycation-related skin aging
Benefits:
- Helps protect against the glycation phenomenon
- Helps prevent the visible effects associated with glycation
- Supports the integrity of the skin's mechanical properties
- Helps preserve skin suppleness
- Helps improve the appearance of wrinkles
- Restores visible vitality to tired-looking skin
- Promotes a brighter, more radiant complexion
- Supports a preventative approach to the first signs of skin aging
What Is Glycation — And Why Does It Matter for Skin?
Our bodies use glucose for energy.
When excess glucose binds to proteins within the skin, a natural chemical reaction called glycation can occur.
This process can create compounds known as Advanced Glycation End Products, or A.G.E.s.
Within the skin, glycation is particularly relevant because it can affect structural proteins such as collagen and elastin.
These proteins help give skin its:
- Firmness
- Flexibility
- Suppleness
- Structural support
When glycation affects these proteins, they can become more rigid and function less efficiently.
Over time, this may contribute to visible changes such as wrinkles, reduced suppleness and a complexion that appears less vibrant.
This is why Sérum A-Glyca is not simply another wrinkle serum.
Its focus is specifically on helping protect the skin against one biological mechanism associated with visible skin aging.
How to Use:
After cleansing, apply a few drops of Sérum A-Glyca morning and evening to the face, neck and décolleté.
Press gently into the skin using the palms of the hands until completely absorbed.
Within a Biologique Recherche routine, apply after cleansing and your appropriate Lotion P50 and before your moisturizer.
If using several serums, apply your more fluid serums first.
Avoid contact with the eyes. For external use only.
Loshen & Crem’s Recommendation:
Sérum A-Glyca is one of the more fascinating Biologique Recherche serums because it isn't simply asking, “Do you have wrinkles?”
It is looking at why skin structure changes over time.
We think about A-Glyca when a client tells us:
- “I'm starting to see the first changes in my skin.”
- “My skin doesn't feel as supple as it used to.”
- “I want to be proactive instead of waiting for deeper wrinkles.”
- “I'm noticing fine lines and changes in firmness.”
- “I want to preserve the quality of my skin for as long as possible.”
This is where A-Glyca fits beautifully.
Rather than waiting until loss of density, firmness or wrinkles become more established, Sérum A-Glyca takes a targeted approach to one of the biological processes associated with those changes.
Think of it as structural preservation through an anti-glycation approach.
Sérum A-Glyca vs. Progeskin
Both address visible skin aging, but they focus on very different biological mechanisms.
Choose Sérum A-Glyca when the priority is:
- Glycation
- First signs of skin aging
- Preserving suppleness
- Protecting skin structural proteins
- A preventative approach to wrinkles and loss of flexibility
Choose Progeskin when visible signs of skin aging are becoming more established and the concerns include:
- Changes in firmness
- Loss of tone
- Reduced plumpness
- Wrinkles
- A broader change in overall skin quality
In the simplest terms:
- A-Glyca = glycation protection + early signs of aging
- Progeskin = broader visible aging + firmness + tone + plumpness
Depending on your Skin Instant, the two may sometimes complement one another within a professionally designed routine.
Sérum A-Glyca vs. Collagène Originel
Both are connected to collagen, but their purpose is very different.
Sérum A-Glyca focuses on helping protect structural proteins such as collagen and elastin from the effects associated with glycation.
Collagène Originel focuses more directly on visible wrinkles, loss of density, plumpness and the structural support of the skin.
Think:
- A-Glyca → protect against glycation + preserve suppleness
- Collagène Originel → density + structure + plumping + wrinkles
If you're beginning to notice the first visible changes in your skin, A-Glyca may be the more preventative choice.
If wrinkles are becoming more established and the skin appears thinner or less densely supported, Collagène Originel may be more targeted.
Ingredients:
- Albizia Julibrissin Bark Extract: A botanical extract at the heart of Sérum A-Glyca's targeted anti-glycation formula.
- Decarboxy Carnosine HCl: A carnosine-derived ingredient incorporated into the serum's A.G.E.-focused complex.
- Glycerin: A humectant that helps maintain hydration and skin comfort.
- Papaver Rhoeas Petal Extract: Red poppy extract included within the serum's skin-conditioning formula.
- Butylene Glycol & Propylene Glycol: Humectant and conditioning ingredients that help support hydration and the serum's lightweight texture.
Full INCI List:
Water (Aqua), Albizia Julibrissin Bark Extract, Glycerin, Propylene Glycol, Phenoxyethanol, Decarboxy Carnosine HCl, Papaver Rhoeas Petal Extract, Butylene Glycol, Ethylhexylglycerin, Sodium Benzoate.
The lists of ingredients used in Biologique Recherche products are updated regularly. Before using a Biologique Recherche product, please refer to the ingredient list on its packaging.
If you have allergies or known ingredient sensitivities, please contact us at info@loshen.ca before purchasing. Our team will be happy to help verify the most current ingredient list for you.
Frequently Asked Questions
What is Biologique Recherche Sérum A-Glyca?
Sérum A-Glyca is an A.G.E. protection and anti-glycation facial serum from Biologique Recherche recommended for Skin Instants showing the first signs of skin aging.
It helps protect against the glycation phenomenon while supporting skin suppleness, radiance and vitality.
What is glycation in the skin?
Glycation is a natural chemical reaction in which excess glucose binds to proteins.
Within the skin, this can affect structural proteins such as collagen and elastin, making them more rigid and less able to perform their normal functions effectively.
What are Advanced Glycation End Products or A.G.E.s?
A.G.E.s are compounds produced through the glycation process.
They can bind to proteins within the skin and affect their normal mechanical properties, which is why glycation is associated with visible skin aging.
Does Sérum A-Glyca remove existing A.G.E.s?
Biologique Recherche currently describes Sérum A-Glyca as helping fight against and prevent the glycation phenomenon.
We would not describe it as literally removing all existing A.G.E.s or reversing glycation entirely. Its role is better understood as a targeted topical serum designed to help protect skin against this biological process.
Is A-Glyca only for people who eat a lot of sugar?
No.
Glycation is a biological process that can occur naturally within the body, so we would not choose Sérum A-Glyca based solely on someone's diet.
The more important question is whether its anti-glycation and preventative approach makes sense for your current Skin Instant.
Is Sérum A-Glyca an anti-wrinkle serum?
Yes. Biologique Recherche classifies A-Glyca as both anti-glycation and anti-wrinkle.
Its distinction is that it approaches visible skin aging through the specific mechanism of glycation rather than simply targeting wrinkles at the surface.
When should I start using Sérum A-Glyca?
Biologique Recherche recommends Sérum A-Glyca for Skin Instants showing the first signs of skin aging rather than prescribing it according to a specific age.
We prefer this approach because skin does not follow a birthday calendar.
What is the difference between A-Glyca and Progeskin?
A-Glyca focuses specifically on glycation and is recommended for the first signs of skin aging.
Progeskin takes a broader approach to visible aging and is designed to improve overall skin appearance, firmness, tone and plumpness.
What is the difference between A-Glyca and Collagène Originel?
A-Glyca focuses on protecting skin proteins from the glycation phenomenon.
Collagène Originel focuses more specifically on visible wrinkles, loss of density, plumping and the structural support of the skin.
Can I use A-Glyca with other Biologique Recherche serums?
Yes. Depending on your Skin Instant, A-Glyca may be layered with appropriate hydrating, firming or targeted Biologique Recherche serums.
More serum does not automatically mean better results, however. If you are unsure how to combine them, our skin experts can help simplify your routine.
Can I use Sérum A-Glyca every day?
Yes. Biologique Recherche currently recommends applying a few drops morning and evening.
When should I apply Sérum A-Glyca?
Apply it after cleansing and your appropriate Lotion P50. If using several serums, apply the most fluid serum first and follow with your moisturizer.
Who should use Sérum A-Glyca?
It is particularly suited to anyone noticing the first visible changes in skin firmness, suppleness, wrinkles or vitality and wanting to incorporate an anti-glycation approach into their routine.
Where can I buy Biologique Recherche Sérum A-Glyca?
Biologique Recherche Sérum A-Glyca is available from Loshen & Crem online and at our Edmonton, Alberta boutique.
Our skin experts can also help determine whether A-Glyca, Progeskin, Collagène Originel or another Biologique Recherche serum is best suited to your current Skin Instant.
Biologique Recherche Skin Reaction Policy
At Loshen & Crem, we highly recommend completing a consultation with one of our skin experts before introducing a new Biologique Recherche product into your routine.
In the event of a skin reaction, Biologique Recherche may require:
- Clear photos of the reaction
- Photos of the product and lot number
- Proof of an online consultation with one of our skin experts
If you choose to purchase a Biologique Recherche product without a consultation and experience a reaction, we may be unable to provide a refund under the brand's policy.
If you are unsure whether Sérum A-Glyca is right for your Skin Instant, our team is always available to help.
Free Express Shipping with orders over $199
Available at our Edmonton Boutique
Ship to Canada only
Pickup available at Loshen & Crem
Usually ready in 24 hours

Serum A-Glyca
30 ml
Loshen & Crem
5238 Windermere Boulevard
Edmonton AB T6W 0L9
Canada
Returns & Refunds
At Loshen & Crem, we understand that sometimes, even the most carefully chosen product might not be "the one."
- Returns: You have 30 days from delivery to return any unopened and unused products in perfect condition—just as they arrived.
- Refunds: If your return reaches us within 30 days of purchase, you’ll have the choice between a refund or store credit (your preference, naturellement). After 30 days, store credit is your only option. Beyond 40 days, refunds and credits are no longer possible.
Final Sale Items
For transparency, certain items are final sale and not eligible for return or exchange:
- Products on sale
- Products marked “Final markdown” on our online store
- Gift cards
- Promotional kits and deluxe samples
- Limited-edition or seasonal item
Shipping Policy
At Loshen & Crem, we take delivering your skincare treasures très seriously. From Canada to the U.S., we’re here to ensure your beauty cabinet is always well-stocked.
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Free Shipping:
- Canada: Complimentary EXPRESS shipping on orders over $199 CAD (after discounts and before taxes).
- United States: Complimentary EXPRESS shipping on orders over $350 USD.
- During our annual sales, enjoy free EXPEDITED shipping for orders over $250 CAD (or $450 USD).
- For smaller indulgences, shipping is $27.95 CAD within Canada and $35 USD to the U.S.
P.S. We ship to P.O. Boxes via Canada Post—but not during strikes. C’est compliqué.
Processing Time:
We aim to dispatch your order within 2 business days, though peak sales and payment verifications may require a touch more patience.
Please note that if you make any changes with the courier after the dispatch, our carrier will charge a $32 fee. In addition, we will have to withdraw 800 points from your La Crème Points account. We appreciate your understanding.
Our processing time starts from the moment your order is successfully submitted and may take up to 2 business days to dispatch your order. However, please be aware that processing and handling time may be extended during peak sale periods. Before we can ship your order, we may need to hold your order for payment verification and confirm your details with your card issuer.
We will do our very best to minimize delays.
Shipping Rates & Delivery Times
Estimated Delivery Times (Canada):
- British Columbia & Alberta: 1–2 business days
- Manitoba & Saskatchewan: 1–2 business days
- Quebec & Ontario: 1–2 business days
- Atlantic Provinces: 1–3 business days
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United States: Delivery times vary by region:
- Zone 1: Eastern States – 3–4 business days
- Zone 2: Central States – 4–5 business days
- Zone 3: Western States – 5 business days
Remote areas may experience longer shipping times.Please Note: Shipping windows are estimates and not guarantees. Delays may occur due to weather, traffic, or additional verification processes.
Shipping Address Details
For a smooth delivery, please provide all relevant information, including buzzer codes, directional suffixes (North, South, etc.), or special instructions.
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Address Changes: Once your package has left our warehouse, address updates cannot be made. If you need to make changes before dispatch, email us at info@loshen.ca with your order details.
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Carrier Fees: Any changes made with the courier after dispatch will incur a $32 CAD fee, and the Free Express Shipping option will be deducted from your La Crème Points account.
Tracking Your Order
All shipments include tracking information, so you can follow your package from our warehouse to your door. A confirmation email with your tracking number will be sent once your order is dispatched.
Damaged or Lost Packages
- Damaged Parcels: If your order arrives damaged, please contact us at info@loshen.ca with photos and details. We’ll work to resolve the issue promptly.
- Lost or Stolen Packages: If your package is marked "delivered" but hasn’t arrived, please contact the carrier directly to file a claim.
Tips to Avoid Lost or Stolen Packages:
- Opt for a signature upon receipt (required for orders over $350 CAD).
- Have your package delivered to your workplace.
- If you’re not home on the expected delivery date, ask a neighbor to receive your package.
Unclaimed Parcels
If your package is returned to us unclaimed, we’ll issue a refund minus a $29.95 CAD return shipping fee.
Free Samples
We believe every order deserves a little extra care! Expect 1–3 complimentary samples selected by our Skincare Specialists to perfectly complement your order.
Loyalty Rewards: La Crem Points
Earn La Crème Points with every purchase and redeem them for future orders. From time to time, we also offer Free Gifts With Purchase (GWP) for select brands, but these are available only while supplies last.
At Loshen & Crem, we aim to deliver excellence at every step of your skincare journey, with care and a touch of elegance. Questions? Don’t hesitate to reach out—we’re always happy to assist!
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A final gesture of care, a whisper of radiance.
La Touche Finale
In this short video, discover how to apply your Biologique Recherche Finishing Serum, a precious step in your ritual that elevates your skin to its most refined state.
With just a few drops, pressed gently into the skin, your complexion is left silky, luminous, and perfectly sealed.






