

Biologique Recherche Crème PTO Métamorphique
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The facial-architecture firming cream, formerly Crème ADN Métamorphique. For Skin Instants lacking structure and tone, it helps the face and neck look firmer, with more defined contours and a refined facial oval.
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Regular $149+
Priority $249+
Régulière dès 149 $
Prioritaire dès 249 $
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Biologique Recherche Crème PTO Métamorphique
50 ml
Loshen & Crem
5238 Windermere Boulevard
Edmonton AB T6W 0L9
Canada
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At a glance
- Step
- Cream, after serums
- When
- Morning and evening
- Texture
- Cream, massaged in until absorbed
- Suits
- Skin lacking structure and tone
Choose options


Product details
A closer look.
Formerly known as Crème ADN Métamorphique, Biologique Recherche Crème PTO Métamorphique is the next generation of the brand's iconic firming cream, now designed around one of the most visible changes in the face: ptosis, the gradual downward shift that can occur as the skin loses support and facial contours become softer. You may notice it first in the cheeks, jawline, facial oval, lower face and neck. Officially positioned as firming, restructuring and tautening, its formula helps restore visible tone while making the contours of the face and neck appear more defined and harmonious. With continued use, the complexion looks firmer and better supported, and the facial oval appears visibly refined. This is a genuine reformulation, not a packaging update. The current formula is built around Smithsonite Extract, Rye Seed Extract, White Peony Root Extract, Helichrysum Stoechas Extract, Alteromonas Ferment Extract, Plantain, Baobab Pulp, Goji Fruit and Grape Juice Extracts. More than a moisturizer for "mature skin", it is a cream for facial architecture, recommended according to the Skin Instant rather than age.
Why you’ll love it.
Crème PTO Métamorphique is what we think about when a client tells us, "It's not really wrinkles that bother me, it's the shape." When the jawline softens, jowls appear or the neck is changing, this is one of the most targeted Biologique Recherche creams we would consider. We also love that its new positioning is so much clearer: facial contour, skin tone and ptosis. And for everyone who asks what replaces Crème ADN Métamorphique, the answer is easy: this does.
Pairs well with.
Ingredients, explained.
Explore the formulaFormula note 01
Smithsonite Extract
A mineral-derived ingredient that appears very high in the formula, part of the cream's protective, skin-supporting complex.
Formula note 02
Secale Cereale (Rye) Seed Extract
A rye-derived botanical extract incorporated into the firming formulation.
Formula note 03
Paeonia Albiflora Root Extract
White peony root extract included within the targeted skin-supporting complex.
Formula note 04
Helichrysum Stoechas Extract
A botanical extract incorporated into the formula's firming and conditioning system.
Formula note 05
Alteromonas Ferment Extract
A marine-derived ferment included within the restructuring formula.
Formula note 06
Vitis Vinifera Grape Juice Extract
A grape-derived ingredient incorporated into the antioxidant-supporting complex.
The full formula
How to use
-
01
Apply after the Lotion P50 selected for your Skin Instant and your serums, such as VG Tensil or Sérum Matriciel Visage.
-
02
Apply Crème PTO Métamorphique morning and evening to the face, neck and décolleté.
-
03
Massage using deep, upward movements until completely absorbed.
-
04
Pay particular attention to areas where loss of tone or definition is most noticeable: the lower cheeks, jawline and neck.
-
05
Apply enough to comfortably cover the face, neck and décolleté.
-
06
For external use only.
Spend an extra few seconds on the lower cheeks, jawline and neck, using deep upward movements: that is where loss of definition shows first.
Your routine
Lotion P50
Apply the Lotion P50 selected for your Skin Instant.
Biologique Recherche Lotion P50TSerum
If recommended, apply VG Tensil, a targeted firming serum.
Biologique Recherche VG TensilSerum
If recommended, apply Sérum Matriciel Visage, a targeted structural serum.
Biologique Recherche Sérum Matriciel VisageThis product
Cream
Massage into the face, neck and décolleté with deep, upward movements, morning and evening.
Biologique Recherche Crème PTO MétamorphiqueIn the morning
Apply a broad-spectrum sunscreen, always the last step.
Firmer-looking skin and more defined facial contours.
When to use it
Firmer-looking, more defined contours build with consistent twice-daily use over time.
Massaged in deeply, absorbed completely.
Works well with
The Loshen & Crem experience
The pleasure is in the details.
Thoughtful skincare, from our Edmonton boutique to your daily ritual. Discover carefully chosen dermocosmetic brands, customized samples and the pleasure of a parcel prepared with care.
Knowledge behind the selection.
Our founder’s skincare education experience across Canada shapes how we explain ingredients, textures and the place of each product in a routine.
Samples with you in mind.
Customized samples to complement your order and introduce you to something worth discovering. A little curiosity, beautifully encouraged.
A gift to yourself.
Thoughtful preparation and finishing touches make receiving your skincare part of the pleasure.
A real boutique. A human point of view.
Loshen & Crem is a skincare boutique and facial studio in Edmonton. Our online selection carries that same considered approach.
Your questions, answered.
Is Crème PTO Métamorphique the replacement for Crème ADN Métamorphique?
Yes. It is the current generation of the former Crème ADN Métamorphique, extensively reformulated and now positioned around facial ptosis and contour definition.
What does PTO mean?
PTO refers to the cream's focus on ptosis, the visible downward shift that occurs as facial support and elasticity decrease.
Can I use it on my neck?
Yes. Biologique Recherche specifically instructs application to the face, neck and décolleté.
Is it only for mature skin?
No. It is recommended according to the Skin Instant, specifically skin lacking structure and tone, not a specific age.
What is the difference between PTO Métamorphique and VG Tensil?
VG Tensil is a targeted serum focused on loss of firmness and tone. PTO Métamorphique is the daily cream positioned around facial ptosis, the facial oval and neck contour. Depending on your Skin Instant, the two can work beautifully together.
Is it good for wrinkles?
It may improve the overall look of firmer, more supported skin, but its main focus is loss of structure, tone and facial contour. If wrinkles are your main concern, a more wrinkle-focused cream or serum may be more appropriate.
Skin Reaction Policy
In the event of a reaction, Biologique Recherche requires photos of the reaction and the product, the lot number found on the product or the bottom of the box, and proof of a consultation with one of our estheticians before they can review the concern.
If you choose to purchase without a consultation and experience a reaction, we will be unable to provide a refund. Our team is always happy to answer your questions and help you select the products best suited to your skin.

