Skip to content

Skincare Boutique & Facial Institute

Book Your Appointment

Your bag.

0 items

Your cart is empty

Biologique Recherche Crème PTO Métamorphique

Regular price$232.00 CAD

Tax excluded. Shipping calculated at checkout

The facial-architecture firming cream, formerly Crème ADN Métamorphique. For Skin Instants lacking structure and tone, it helps the face and neck look firmer, with more defined contours and a refined facial oval.

Read more
Biologique Recherche gift with purchase
THE MONTHLY EDIT

Your ritual. Our treat.

Spend more, receive more. We'll automatically show you the highest gift tier your cart qualifies for.

$349+ Cleansing Milk · 50 ml
$399+ Lotion P50 · 50 ml
$499+ Cleansing Milk + P50 · 50 ml each
·

Highest eligible tier applies · One gift per qualifying order · While quantities last

Size:
In stock

Free Shipping Livraison offerte

Regular $149+
Priority $249+
Régulière dès 149 $
Prioritaire dès 249 $

Complimentary Samples Échantillons offerts

With every order Avec chaque commande

30-Day Returns Retours sous 30 jours

View return policy Voir la politique de retour

Track Your Order Suivez votre commande

Follow your delivery Suivre la livraison

Pickup available at Loshen & Crem

Usually ready in 24 hours

Biologique Recherche Crème PTO Métamorphique | Cream - Lifting | Firming | LOSHEN & CREM

Biologique Recherche Crème PTO Métamorphique

50 ml

Loshen & Crem

Pickup available, usually ready in 24 hours

5238 Windermere Boulevard
Edmonton AB T6W 0L9
Canada

+18336957546

Product details

A closer look.

Formerly known as Crème ADN Métamorphique, Biologique Recherche Crème PTO Métamorphique is the next generation of the brand's iconic firming cream, now designed around one of the most visible changes in the face: ptosis, the gradual downward shift that can occur as the skin loses support and facial contours become softer. You may notice it first in the cheeks, jawline, facial oval, lower face and neck. Officially positioned as firming, restructuring and tautening, its formula helps restore visible tone while making the contours of the face and neck appear more defined and harmonious. With continued use, the complexion looks firmer and better supported, and the facial oval appears visibly refined. This is a genuine reformulation, not a packaging update. The current formula is built around Smithsonite Extract, Rye Seed Extract, White Peony Root Extract, Helichrysum Stoechas Extract, Alteromonas Ferment Extract, Plantain, Baobab Pulp, Goji Fruit and Grape Juice Extracts. More than a moisturizer for "mature skin", it is a cream for facial architecture, recommended according to the Skin Instant rather than age.

Why you’ll love it.

Crème PTO Métamorphique is what we think about when a client tells us, "It's not really wrinkles that bother me, it's the shape." When the jawline softens, jowls appear or the neck is changing, this is one of the most targeted Biologique Recherche creams we would consider. We also love that its new positioning is so much clearer: facial contour, skin tone and ptosis. And for everyone who asks what replaces Crème ADN Métamorphique, the answer is easy: this does.

Pairs well with.

Ingredients, explained.

Explore the formula

Formula note 01

Smithsonite Extract

A mineral-derived ingredient that appears very high in the formula, part of the cream's protective, skin-supporting complex.

Formula note 02

Secale Cereale (Rye) Seed Extract

A rye-derived botanical extract incorporated into the firming formulation.

Formula note 03

Paeonia Albiflora Root Extract

White peony root extract included within the targeted skin-supporting complex.

Formula note 04

Helichrysum Stoechas Extract

A botanical extract incorporated into the formula's firming and conditioning system.

Formula note 05

Alteromonas Ferment Extract

A marine-derived ferment included within the restructuring formula.

Formula note 06

Vitis Vinifera Grape Juice Extract

A grape-derived ingredient incorporated into the antioxidant-supporting complex.

The full formula
Water (Aqua), Coco-Caprylate/Caprate, Caprylic/Capric Triglyceride, C10-18 Triglycerides, Smithsonite Extract, Glycerin, C12-16 Alcohols, Methylpropanediol, Cetyl Alcohol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Glyceryl Stearate Citrate, Hydrogenated Lecithin, Palmitic Acid, Pentaerythrityl Tetrastearate, Caprylyl Glycol, Tapioca Starch, Isomalt, Secale Cereale (Rye) Seed Extract, Maltodextrin, 1,2-Hexanediol, Propanediol, Phenylpropanol, Paeonia Albiflora Root Extract, Polysorbate 60, Sorbitan Isostearate, Tocopherol, Helichrysum Stoechas Extract, Helianthus Annuus (Sunflower) Seed Oil, Alteromonas Ferment Extract, Phenethyl Alcohol, Adansonia Digitata Pulp Extract, Lecithin, Lycium Barbarum Fruit Extract, Vitis Vinifera (Grape) Juice Extract, Benzyl Alcohol, Cinnamal, Cinnamyl Alcohol, Plantago Lanceolata Extract, Potassium Sorbate, Sodium Benzoate, Xanthan Gum.
How to use
  1. 01

    Apply after the Lotion P50 selected for your Skin Instant and your serums, such as VG Tensil or Sérum Matriciel Visage.

  2. 02

    Apply Crème PTO Métamorphique morning and evening to the face, neck and décolleté.

  3. 03

    Massage using deep, upward movements until completely absorbed.

  4. 04

    Pay particular attention to areas where loss of tone or definition is most noticeable: the lower cheeks, jawline and neck.

  5. 05

    Apply enough to comfortably cover the face, neck and décolleté.

  6. 06

    For external use only.

Spend an extra few seconds on the lower cheeks, jawline and neck, using deep upward movements: that is where loss of definition shows first.

Your routine

  1. Lotion P50

    Apply the Lotion P50 selected for your Skin Instant.

    Biologique Recherche Lotion P50T
  2. Serum

    If recommended, apply VG Tensil, a targeted firming serum.

    Biologique Recherche VG Tensil
  3. Serum

    If recommended, apply Sérum Matriciel Visage, a targeted structural serum.

    Biologique Recherche Sérum Matriciel Visage
  4. This product

    Cream

    Massage into the face, neck and décolleté with deep, upward movements, morning and evening.

    Biologique Recherche Crème PTO Métamorphique
  5. In the morning

    Apply a broad-spectrum sunscreen, always the last step.

Firmer-looking skin and more defined facial contours.

The daily structural cream step, applied after your serum. Where VG Tensil or Sérum Matriciel Visage provide the targeted serum step, PTO Métamorphique finishes the routine with firming, tautening moisturizing care focused on the facial oval, jawline and neck.

When to use it

Morning and evening, every day.
Firmer-looking, more defined contours build with consistent twice-daily use over time.

Massaged in deeply, absorbed completely.

A cream massaged in with deep, upward movements until completely absorbed. Many people first notice a more comfortable, hydrated skin feel.

Works well with

Apply the Lotion P50 selected for your Skin Instant, then a firming serum such as VG Tensil or Sérum Matriciel Visage, and finish with Crème PTO Métamorphique. Platysma, a single-use 20-minute firming mask for the jawline and submental area, is the intensive lower-face option; your esthetician can tell you whether it belongs in your routine. Add sunscreen in the morning. These pairings are suggestions; your esthetician will personalize the routine to your Skin Instant.

The Loshen & Crem experience

The pleasure is in the details.

Thoughtful skincare, from our Edmonton boutique to your daily ritual. Discover carefully chosen dermocosmetic brands, customized samples and the pleasure of a parcel prepared with care.

Knowledge behind the selection.

Our founder’s skincare education experience across Canada shapes how we explain ingredients, textures and the place of each product in a routine.

Samples with you in mind.

Customized samples to complement your order and introduce you to something worth discovering. A little curiosity, beautifully encouraged.

A gift to yourself.

Thoughtful preparation and finishing touches make receiving your skincare part of the pleasure.

A real boutique. A human point of view.

Loshen & Crem is a skincare boutique and facial studio in Edmonton. Our online selection carries that same considered approach.

Your questions, answered.

Is Crème PTO Métamorphique the replacement for Crème ADN Métamorphique?

Yes. It is the current generation of the former Crème ADN Métamorphique, extensively reformulated and now positioned around facial ptosis and contour definition.

What does PTO mean?

PTO refers to the cream's focus on ptosis, the visible downward shift that occurs as facial support and elasticity decrease.

Can I use it on my neck?

Yes. Biologique Recherche specifically instructs application to the face, neck and décolleté.

Is it only for mature skin?

No. It is recommended according to the Skin Instant, specifically skin lacking structure and tone, not a specific age.

What is the difference between PTO Métamorphique and VG Tensil?

VG Tensil is a targeted serum focused on loss of firmness and tone. PTO Métamorphique is the daily cream positioned around facial ptosis, the facial oval and neck contour. Depending on your Skin Instant, the two can work beautifully together.

Is it good for wrinkles?

It may improve the overall look of firmer, more supported skin, but its main focus is loss of structure, tone and facial contour. If wrinkles are your main concern, a more wrinkle-focused cream or serum may be more appropriate.

Skin Reaction Policy
At Loshen & Crem, we want to ensure you have the best possible experience with Biologique Recherche. Before purchasing any Biologique Recherche product, we highly recommend booking a consultation with one of our estheticians. Consultations are available virtually through Google Meet or in person at our Edmonton boutique. An appointment is required.

In the event of a reaction, Biologique Recherche requires photos of the reaction and the product, the lot number found on the product or the bottom of the box, and proof of a consultation with one of our estheticians before they can review the concern.

If you choose to purchase without a consultation and experience a reaction, we will be unable to provide a refund. Our team is always happy to answer your questions and help you select the products best suited to your skin.
  • 5 stars: 28 (97%)
  • 4 stars: 1 (3%)
  • 3 stars: 0 (0%)
  • 2 stars: 0 (0%)
  • 1 star: 0 (0%)
R
Rochelle
Love it!

Deeply hydrating and instantly comforting on the skin. I started using this when my skin was feeling quite dehydrated, and I noticed a visible difference almost immediately — my skin felt restored, healthier, and much more balanced. I also love the texture; it feels luxurious and nourishing without being heavy.

K
K
Nice texture

Nice texture, hydrating, have not noticed a difference in skin laxity or “lifting” but I have not been using long enough to judge and I don’t believe a cream is a fix for a facelift- I would recommend this for it’s hydrating effects and the hope of tighter skin - it’s a buy for sure for me !!!

M
Micheline
HYDRATING

Crème douce et super hydratante J'ADORE !!!!!

O
Olga
Get It

I've been a fan of ADN version ... enjoying it so far ...

C
Catherine
New favourite

I got the old version after trying a sample - I was pleasantly surprised! It leaves the skin hydrated and nourished without a greasy finish. I can’t speak to the lifting benefits yet but my skin feels firmer.

A
Amanda
Hydrating!

I’ve loved this creme, my skin feels soft and hydrated without feeling greasy

V
Victoria
Very hydrating

I'm from Alberta and have dry sensitive acne prone skin. I struggle to find a moisturizer that doesn't break me out, doesn't irritate my skin and is hydrating enough! This one fits the bill! Finally a moisturizer that I don't have to use half the jar to not feel like a raisin!!

R
RL
A Game Changer for Radiant, Youthful Skin!

I’ve been using CREME ADN METAMORPHIQUE for a few weeks now, and I am absolutely impressed with the results! This cream has transformed the texture of my skin, leaving it smoother, firmer, and deeply hydrated. I love how lightweight it feels, yet it delivers intense moisture without being greasy. My complexion looks more radiant, and I’ve noticed a visible reduction in fine lines. It’s become a staple in my skincare routine, and I highly recommend it for anyone looking for a luxurious and effective anti-aging cream!”

L
Letisha
Very very lovely

This moisturizer is very light and yet very nourishing and soothing on the skin. It has a lovely smell and sits well under makeup. I haven’t been using it long enough to see results but love using it as a day cream. Gives a nice glow 🥰

C
Christina
Hydration!

Love love love this moisturizer! Easily absorbs and hydrates my dry skin

H
H.
Acne-Approved

ADN has the most luxurious, soft texture unlike any cream I’ve used. It melts into the skin and leaves your skin calm, glowing and nourished for the day. Love that it’s for aging skin but also repairs the barrier! And in case you needed yet another reason to use this cream, it’s incredible on adult-acne. My VISIA showed much less inflammation and breakouts when I used this paired with Osmosis stemfactor. Would purchase over and over again!

v
vanessa
Great texture

For such a hydrating cream this does not get greasy or pill-which a lot do. Love all BR but this one is especially soothing

H
Halyna

Love the texture of the cream, my skin felt plumped right after the first time I use it

B
Bella
Creme ADN Metamorphique

This is my 2nd or 3rd bottle of Creme ADN Metamorphique and I love it. It's good for summer or winter months. Leaves my skin feeling hydrated and soft - even in the morning! Highly recommend this cream!

T
Tetiana
excellent crème

excellent crème

K
Kevin
Excellent

This cream really does work wonders and I have now purchased another jar - - -Love BR products.

N
Nancy
Plumping but gentle

I have to admit that I was skeptical about this cream when I received it as a sample but enjoyed it so much that I'm about to buy the full size, really plumps and firms the face and doesn't irritate my sensitive skin prone to breakouts.

K
Kevin
It works wonders

This cream does what it says it does and it's made a Hugh difference to the lines and crows feet around my eyes. Easy to apply, goes on evenly and has a nice texture. Very impressed with the BR product line.

W
Wendy
BR did it again!

I would be repurchasing this cream again when I run out. It firms and hydrates my skin nicely.

K
Khuraman
Incredibly firming!!

I am only 34 and do not have fine lines (thank you serum elastine and the new collagene one!) but I do have my skin sagging especially around my mouth and this cream does an incredible job both firming and sort of lifting as well as acting like a moisturizer. I am a combo/normal skin and this one sinks right in and I love that it is a pearly cream and not one of their brown creams as this one adds some light and the brown creams make my face look dull. Thank you BR and Loshen for shipping it SO FAST!

L
LR
Lifting, plumping + hydrating!

I'm very impressed with the softening of lines in my forehead + the improvement in the volume of the skin under my eyes! I'm also noticing that the results from my micro current use (NuFace device) are more noticeable + last longer when I'm using this creme regularly; it's very supportive in maintaining the lifting + toning effects. Very happy to have this product in my rotation.

m
m.D.
Love it

I really like this cream, the best combination with the Elastine serum!

A
A.K.
Does it all!

I can’t believe there’s a cream that tightens and plumps my skin, while the active ingredients protect my skin from signs of aging. I received a sample size and would absolutely repurchase!

L
L
Beautiful

An exceptional firming and hydrating cream. Would definitely repurchase.

O
Olga
Perfect moisturizer

BR has such an amazing assortment, it's so hard to choose the perfect match. I'm 40+ with sensitive/reactive/combination-to-dry skin and this moisturizer is an intense anti-aging treatment providing fantastic hydration!

I
Ingrid
Great product

Fantastic service. Great product

E
Elaine
“Beautiful”

This cream absorbs beautifully into the skin leaving it feeling soft but firm as described it would. I will definitely repurchase!!!!

K
Kate
Better than the old version

Not smelly

M
MARIAM
Great all purpose creme

Love this lightweight fast absorbing effective creme. Tones and lifts and plumps. Perfect for neck and décolleté.

Worth the wait.

We’ll email you when this item is back.

For this restock alert only. This does not sign you up for our newsletter. Privacy policy.