

Creme PTO Metamorphique
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THE FACIAL ARCHITECTURE FIRMING CREAM
Formerly known as Crème ADN Métamorphique, Biologique Recherche Crème PTO Métamorphique is the next generation of the brand’s iconic firming cream — now specifically designed around one of the most visible changes in facial structure: ptosis.
Ptosis refers to the gradual downward shift that can occur when the skin loses structural support and facial contours become softer.
You may notice it first through the:
- Cheeks
- Jawline
- Facial oval
- Lower face
- Neck
Crème PTO Métamorphique is designed for exactly this evolution.
Its firming, restructuring and tautening formula helps restore visible tone while making the contours of the face and neck appear more defined and harmonious.
With continued use, the complexion looks firmer and better supported, while the facial oval appears visibly refined.
This is not simply a moisturizer for “mature skin.”
It is a cream for facial architecture.
Skin Instant:
Recommended for Skin Instants lacking structure and tone.
We particularly think about Crème PTO Métamorphique when skin is experiencing:
- Loss of firmness
- Reduced facial tone
- Softer-looking jawline
- Changes in the facial oval
- Visible sagging
- Jowl formation
- Reduced neck definition
- Skin that appears less structurally supported
- Changes associated with facial ptosis
What Is Facial Ptosis?
Ptosis is the term used to describe the visible downward movement of facial tissues as structural support weakens.
Several changes can contribute.
Over time:
- Collagen decreases
- Elastin changes
- Facial muscles lose some tone
- The skin becomes less resistant to gravity
- Facial volumes can redistribute
As a result, areas that once appeared more defined may begin to look softer.
This can show up as:
- Jowls
- Reduced jawline definition
- Softer cheeks
- A less defined facial oval
- Changes through the neck
This is why Crème PTO Métamorphique is more interesting than simply calling it a “lifting cream.”
It is designed around the visible architecture of the face.
Clinically Evaluated Facial Ptosis
In a Biologique Recherche clinical study, Crème PTO Métamorphique was applied twice daily for 56 days.
The study included 21 participants aged 46 to 65 with visible skin laxity.
After 56 days:
Facial ptosis was reduced by 6%
The result supports the cream’s targeted role in helping facial contours appear firmer and more defined with consistent use.
Why the Jawline Changes
The jawline is one of the places clients often notice structural changes first.
When the skin and underlying support network become less resistant to downward movement, the boundary between:
face → jaw → neck
can begin to appear less distinct.
That is why simply focusing on wrinkles does not necessarily address every visible sign of skin aging.
You can have relatively smooth skin and still notice:
“My jawline isn't what it used to be.”
That is not primarily a wrinkle conversation.
It is a structure + tone + contour conversation.
And that is precisely where PTO Métamorphique belongs.
How to Use:
- Apply Crème PTO Métamorphique morning and evening to the face, neck and décolleté.
- Massage using deep, upward movements until completely absorbed.
- Pay particular attention to areas where loss of tone or facial definition is most noticeable, including the lower cheeks, jawline and neck.
For external use only.
Loshen & Crem’s Recommendation:
Crème PTO Métamorphique is what we think about when a client tells us:
- “My jawline is becoming softer.”
- “I'm noticing jowls.”
- “My skin doesn't feel as firm as it used to.”
- “My neck is changing.”
- “It's not really wrinkles that bother me — it's the shape.”
- “I used to love Crème ADN Métamorphique. What replaces it?”
That last question is easy.
This does.
PTO Métamorphique is the evolution of Crème ADN Métamorphique, but we actually think its new positioning is much clearer.
ADN Métamorphique had a broad firming story.
PTO Métamorphique tells us exactly where to look:
facial contour + skin tone + ptosis.
If the jawline and facial oval are what you notice first in the mirror, this is one of the most targeted Biologique Recherche creams we would consider.
Formerly Crème ADN Métamorphique: What Changed?
Clients who loved Crème ADN Métamorphique will recognize the philosophy, but the formula itself has evolved significantly.
The previous generation contained ingredients such as:
- DNA
- Hydrolyzed Collagen
- Hydrolyzed Elastin
- Lanolin Oil
- Niacinamide
The current PTO Métamorphique formula takes a completely different approach with:
- Smithsonite Extract
- Rye Seed Extract
- Paeonia Albiflora Root Extract
- Helichrysum Stoechas Extract
- Alteromonas Ferment Extract
- Plantago Lanceolata Extract
- Baobab Pulp Extract
- Goji Fruit Extract
- Grape Juice Extract
This is not a minor packaging update.
It is a genuine reformulation and repositioning around visible loss of facial support and ptosis.
Crème PTO Métamorphique vs. VG Tensil
This is probably one of the most useful comparisons.
Both focus on firmness and tone.
But one is a serum and one is the finishing cream.
VG Tensil provides targeted serum support for:
- Loss of tone
- Skin laxity
- Softer facial contours
- Reduced definition
Crème PTO Métamorphique provides the moisturizing treatment step focused on:
- Facial ptosis
- Firmness
- Jawline definition
- Facial oval
- Neck contour
Think:
- VG Tensil → targeted firming serum
- PTO Métamorphique → facial architecture cream
Depending on your Skin Instant, the two can make beautiful sense together.
Crème PTO Métamorphique vs. Sérum Matriciel Visage
These two products both belong in a structure-focused routine, but their roles differ.
Sérum Matriciel Visage is an intensive facial-structure serum focused on:
- Facial volumes
- Tissue support
- Contours
- Structural appearance
Crème PTO Métamorphique provides:
- Daily moisturizing support
- Firmness
- Tautening
- Facial oval definition
- Neck contour support
Think:
- Matriciel Visage → targeted structural serum
- PTO Métamorphique → daily structural cream
For clients whose primary concern is visible change in facial architecture, this is one of the most logical combinations to discuss.
Crème PTO Métamorphique vs. Platysma
This is a matter of daily treatment vs. intensive mask.
Platysma is a single-use 20-minute treatment targeted specifically to:
- The chin
- Jawline
- Submental area
- Lower facial contour
Crème PTO Métamorphique is the daily treatment for:
- Facial ptosis
- Loss of firmness
- Facial oval
- Neck contour
- Ongoing structural support
Think:
- Platysma → immediate lower-face treatment
- PTO Métamorphique → everyday facial-contour cream
Is PTO Métamorphique a “Lifting Cream”?
You will often see it described that way, and visually that is certainly the goal.
But we prefer more precise language.
Crème PTO Métamorphique is officially positioned as:
- Firming
- Restructuring
- Tautening
Its clinical study specifically evaluated facial ptosis.
So rather than promising that a cream physically lifts facial tissues in the same way as a procedure, we describe the result as:
firmer-looking skin + more defined facial contours + reduced visible ptosis.
That is both accurate and meaningful.
Ingredients:
- Smithsonite Extract: A mineral-derived ingredient appearing very high in the current formula and incorporated into the cream’s protective and skin-supporting complex.
- Secale Cereale (Rye) Seed Extract: Rye-derived botanical extract incorporated into the firming formulation.
- Paeonia Albiflora Root Extract: White Peony Root Extract included within the targeted skin-supporting complex.
- Helichrysum Stoechas Extract: Botanical extract incorporated into the formula’s firming and conditioning system.
- Alteromonas Ferment Extract: Marine-derived ferment included within the restructuring formula.
- Adansonia Digitata Pulp Extract: Baobab-derived ingredient incorporated into the current formulation.
- Plantago Lanceolata Extract: Plantain-derived botanical ingredient included within the contour-focused formula.
- Lycium Barbarum Fruit Extract: Goji berry extract providing botanical skin-conditioning support.
- Vitis Vinifera Grape Juice Extract: Grape-derived ingredient incorporated into the antioxidant-supporting complex.
- Glycerin: Helps support hydration and skin comfort.
- Hydrogenated Lecithin: Helps condition the skin and support the lipid environment of the formula.
- Tocopherol: Vitamin E provides antioxidant and conditioning support.
Full INCI List:
Water (Aqua), Coco-Caprylate/Caprate, Caprylic/Capric Triglyceride, C10-18 Triglycerides, Smithsonite Extract, Glycerin, C12-16 Alcohols, Methylpropanediol, Cetyl Alcohol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Glyceryl Stearate Citrate, Hydrogenated Lecithin, Palmitic Acid, Pentaerythrityl Tetrastearate, Caprylyl Glycol, Tapioca Starch, Isomalt, Secale Cereale (Rye) Seed Extract, Maltodextrin, 1,2-Hexanediol, Propanediol, Phenylpropanol, Paeonia Albiflora Root Extract, Polysorbate 60, Sorbitan Isostearate, Tocopherol, Helichrysum Stoechas Extract, Helianthus Annuus (Sunflower) Seed Oil, Alteromonas Ferment Extract, Phenethyl Alcohol, Adansonia Digitata Pulp Extract, Lecithin, Lycium Barbarum Fruit Extract, Vitis Vinifera (Grape) Juice Extract, Benzyl Alcohol, Cinnamal, Cinnamyl Alcohol, Plantago Lanceolata Extract, Potassium Sorbate, Sodium Benzoate, Xanthan Gum.
The lists of ingredients used in Biologique Recherche products are updated regularly. Before using a Biologique Recherche product, please refer to the ingredient list on its packaging.
If you have allergies or known ingredient sensitivities, please contact us at info@loshen.ca before purchasing. Our team will be happy to help verify the most current ingredient list for you.
Questions We Get About Crème PTO Métamorphique
What is Biologique Recherche Crème PTO Métamorphique?
Crème PTO Métamorphique is a firming, restructuring and tautening facial cream designed specifically for Skin Instants lacking structure and tone.
It focuses on visible facial ptosis and helps the face and neck appear firmer and more defined.
Is Crème PTO Métamorphique the replacement for Crème ADN Métamorphique?
Yes.
Crème PTO Métamorphique is the current generation of the former Crème ADN Métamorphique.
The product has been extensively reformulated and is now positioned more specifically around facial ptosis and contour definition.
What does PTO mean?
PTO refers to the cream’s focus on ptosis, the visible downward shift that occurs as facial structural support and elasticity decrease.
What is facial ptosis?
Facial ptosis describes visible sagging or downward movement of facial tissues associated with reduced structural support.
It can contribute to jowls, softer facial contours and reduced jawline definition.
Does Crème PTO Métamorphique help jowls?
Biologique Recherche specifically connects facial ptosis with the development of jowls.
The cream is designed to improve visible firmness and contour definition and has been clinically evaluated for reduction in facial ptosis.
Does PTO Métamorphique help the jawline?
Yes.
Facial oval and neck definition are central to its current positioning, making it particularly relevant when the jawline appears softer or less defined.
Can I use Crème PTO Métamorphique on my neck?
Yes.
Biologique Recherche specifically instructs application to the face, neck and décolleté.
Does Crème PTO Métamorphique lift the neck?
It is designed to help the neck and facial contours appear firmer and more defined.
We would describe this as a cosmetic firming and tautening effect rather than permanent structural lifting.
What were the clinical results?
In a Biologique Recherche clinical study involving 21 participants aged 46 to 65 with visible skin laxity, Crème PTO Métamorphique was applied twice daily for 56 days.
Facial ptosis was reduced by 6%.
How long does PTO Métamorphique take to work?
The current clinical study assessed results after 56 days of twice-daily use.
Skin feel and hydration may be noticed sooner, but meaningful contour-focused results should be evaluated with consistent use over time.
Is Crème PTO Métamorphique only for mature skin?
Biologique Recherche does not currently recommend it according to a specific age.
It is recommended according to the Skin Instant — specifically skin lacking structure and tone.
That is the approach we prefer.
Skin does not check your birth certificate before losing firmness.
Does Crème PTO Métamorphique stimulate collagen and elastin?
Biologique Recherche explains that decreases in collagen and elastin contribute to facial ptosis.
However, the current consumer page does not make a broad direct claim that the finished cream clinically stimulates collagen, elastin and hyaluronic acid synthesis.
We therefore prefer to describe it according to its proven result:
improved visible firmness + more defined contours + reduced facial ptosis.
Is PTO Métamorphique good for wrinkles?
It may improve the overall appearance of firmer, more supported skin, but its primary current indication is loss of structure, tone and facial contour.
If wrinkles are your main concern, a more specifically wrinkle-focused cream or serum may be more appropriate.
What is the difference between PTO Métamorphique and VG Tensil?
VG Tensil is a targeted serum focused on loss of firmness and tone.
PTO Métamorphique is the daily moisturizing cream specifically positioned around facial ptosis, facial oval and neck contour.
What is the difference between PTO Métamorphique and Platysma?
Platysma is a single-use 20-minute firming mask targeted specifically to the jawline and submental area.
PTO Métamorphique is an everyday cream used morning and evening to support facial and neck contours over time.
Can I use PTO Métamorphique with Sérum Matriciel Visage?
Depending on your Skin Instant, yes.
Both belong to the broader structural and contour-focused Biologique Recherche category, with Matriciel Visage providing the serum step and PTO Métamorphique providing the cream step.
Can I use Crème PTO Métamorphique every day?
Yes.
Biologique Recherche currently recommends applying it morning and evening.
How much should I use?
Apply enough to comfortably cover the face, neck and décolleté and massage with deep upward movements until absorbed.
The current Biologique Recherche instructions do not specify that every client must use a particular “hazelnut-sized” amount.
Where can I buy authentic Biologique Recherche Crème PTO Métamorphique?
Biologique Recherche Crème PTO Métamorphique is available from Loshen & Crem online and at our Edmonton, Alberta boutique.
Our skin experts can also help determine whether PTO Métamorphique, VG Tensil, Sérum Matriciel Visage, Platysma or another Biologique Recherche firming treatment best suits your current Skin Instant.
Biologique Recherche Skin Reaction Policy
At Loshen & Crem, we highly recommend completing a consultation with one of our skin experts before introducing a new Biologique Recherche product into your routine.
In the event of a skin reaction, Biologique Recherche may require:
- Clear photos of the reaction
- Photos of the product and lot number
- Proof of an online consultation with one of our skin experts
If you choose to purchase a Biologique Recherche product without a consultation and experience a reaction, we may be unable to provide a refund under the brand's policy.
If you are unsure whether Crème PTO Métamorphique is right for your Skin Instant, our team is always available to help.
Free Express Shipping with orders over $199
Available at our Edmonton Boutique
Ship to Canada only
Pickup available at Loshen & Crem
Usually ready in 24 hours

Creme PTO Metamorphique
50 ml
Loshen & Crem
5238 Windermere Boulevard
Edmonton AB T6W 0L9
Canada
Returns & Refunds
At Loshen & Crem, we understand that sometimes, even the most carefully chosen product might not be "the one."
- Returns: You have 30 days from delivery to return any unopened and unused products in perfect condition—just as they arrived.
- Refunds: If your return reaches us within 30 days of purchase, you’ll have the choice between a refund or store credit (your preference, naturellement). After 30 days, store credit is your only option. Beyond 40 days, refunds and credits are no longer possible.
Final Sale Items
For transparency, certain items are final sale and not eligible for return or exchange:
- Products on sale
- Products marked “Final markdown” on our online store
- Gift cards
- Promotional kits and deluxe samples
- Limited-edition or seasonal item
Shipping Policy
At Loshen & Crem, we take delivering your skincare treasures très seriously. From Canada to the U.S., we’re here to ensure your beauty cabinet is always well-stocked.
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Free Shipping:
- Canada: Complimentary EXPRESS shipping on orders over $199 CAD (after discounts and before taxes).
- United States: Complimentary EXPRESS shipping on orders over $350 USD.
- During our annual sales, enjoy free EXPEDITED shipping for orders over $250 CAD (or $450 USD).
- For smaller indulgences, shipping is $27.95 CAD within Canada and $35 USD to the U.S.
P.S. We ship to P.O. Boxes via Canada Post—but not during strikes. C’est compliqué.
Processing Time:
We aim to dispatch your order within 2 business days, though peak sales and payment verifications may require a touch more patience.
Please note that if you make any changes with the courier after the dispatch, our carrier will charge a $32 fee. In addition, we will have to withdraw 800 points from your La Crème Points account. We appreciate your understanding.
Our processing time starts from the moment your order is successfully submitted and may take up to 2 business days to dispatch your order. However, please be aware that processing and handling time may be extended during peak sale periods. Before we can ship your order, we may need to hold your order for payment verification and confirm your details with your card issuer.
We will do our very best to minimize delays.
Shipping Rates & Delivery Times
Estimated Delivery Times (Canada):
- British Columbia & Alberta: 1–2 business days
- Manitoba & Saskatchewan: 1–2 business days
- Quebec & Ontario: 1–2 business days
- Atlantic Provinces: 1–3 business days
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United States: Delivery times vary by region:
- Zone 1: Eastern States – 3–4 business days
- Zone 2: Central States – 4–5 business days
- Zone 3: Western States – 5 business days
Remote areas may experience longer shipping times.Please Note: Shipping windows are estimates and not guarantees. Delays may occur due to weather, traffic, or additional verification processes.
Shipping Address Details
For a smooth delivery, please provide all relevant information, including buzzer codes, directional suffixes (North, South, etc.), or special instructions.
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Address Changes: Once your package has left our warehouse, address updates cannot be made. If you need to make changes before dispatch, email us at info@loshen.ca with your order details.
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Carrier Fees: Any changes made with the courier after dispatch will incur a $32 CAD fee, and the Free Express Shipping option will be deducted from your La Crème Points account.
Tracking Your Order
All shipments include tracking information, so you can follow your package from our warehouse to your door. A confirmation email with your tracking number will be sent once your order is dispatched.
Damaged or Lost Packages
- Damaged Parcels: If your order arrives damaged, please contact us at info@loshen.ca with photos and details. We’ll work to resolve the issue promptly.
- Lost or Stolen Packages: If your package is marked "delivered" but hasn’t arrived, please contact the carrier directly to file a claim.
Tips to Avoid Lost or Stolen Packages:
- Opt for a signature upon receipt (required for orders over $350 CAD).
- Have your package delivered to your workplace.
- If you’re not home on the expected delivery date, ask a neighbor to receive your package.
Unclaimed Parcels
If your package is returned to us unclaimed, we’ll issue a refund minus a $29.95 CAD return shipping fee.
Free Samples
We believe every order deserves a little extra care! Expect 1–3 complimentary samples selected by our Skincare Specialists to perfectly complement your order.
Loyalty Rewards: La Crem Points
Earn La Crème Points with every purchase and redeem them for future orders. From time to time, we also offer Free Gifts With Purchase (GWP) for select brands, but these are available only while supplies last.
At Loshen & Crem, we aim to deliver excellence at every step of your skincare journey, with care and a touch of elegance. Questions? Don’t hesitate to reach out—we’re always happy to assist!
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A final gesture of care, a whisper of radiance.
La Touche Finale
In this short video, discover how to apply your Biologique Recherche Finishing Serum, a precious step in your ritual that elevates your skin to its most refined state.
With just a few drops, pressed gently into the skin, your complexion is left silky, luminous, and perfectly sealed.






