
Biophora Bioactive Retinol 60
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Take your skin transformation to the next level with Biophora Bioactive Retinol 60. Designed for those who have successfully built up a tolerance to lower concentrations, this advanced 30mL treatment features a potent 0.60 concentration of encapsulated retinol. This highly effective time-release system delivers intensive, age-defying benefits without the harsh irritation traditionally associated with powerful Vitamin A derivatives. Formulated to aggressively target stubborn hyperpigmentation, melasma, deep fine lines, wrinkles, and acne, it reveals a remarkably smoother, highly refined complexion. Infused with hydrating Squalane and soothing Vitamin E, it protects your delicate moisture barrier while actively repairing the skin. Experience peak clinical results and the radiant, youthful glow your skin deserves!
Important Notice: Biophora is a highly potent brand. To purchase this product, you must first receive a virtual consultation to ensure that this product is best suited and safe for your use.
Benefits:
- Features a potent 0.60 encapsulated retinol for maximum efficacy with a gradual, non-irritating release
- Visibly diminishes deep fine lines, wrinkles, stubborn hyperpigmentation, and melasma
- Helps clear acne and minimizes congestion for a smoother, flawless texture
- Deeply hydrates and defends the skin barrier with nourishing Squalane and Antioxidants
How to Use:
- Crucial First Step: Retinol is a highly active ingredient; perform a patch test at least 24 hours in advance to ensure your skin tolerates it well.
- Apply a small amount to clean, dry skin in the evening.
- Start slow: Even if you have used retinol before, apply only once weekly for the first few weeks when stepping up to this higher concentration.
- Gradually increase application to every other night for a month, progressing to nightly use only as tolerated by your skin.
Pro tip: Always wear a high-quality SPF during the day when using retinol, as it makes your skin highly sensitive to the sun.
Loshen & Crem’s Recommendation:
- Ideal for experienced retinol users with normal to oily skin types who have successfully completed the Bioactive Retinol 30 protocol and are ready for stronger results.
- Perfect for tackling stubborn skin concerns while relying on the formula's Squalane to offset the dryness typical of Canadian winters.
Expert Note: Because this is a highly potent clinical formula, a complimentary virtual consultation with our professional clinic specialists is required prior to purchase. We will ensure your skin barrier is healthy and ready for this powerful step-up!
Ingredients:
Key Ingredients
- Encapsulated Retinol (0.60): A highly effective, non-prescription Vitamin A derivative that releases gradually to target advanced aging and acne while minimizing redness.
- Squalane: Deeply hydrates, softens, and protects the skin barrier, offsetting the dryness often associated with clinical retinol use.
- Vitamin E (Tocopherol): Delivers powerful antioxidant protection to soothe, repair, and defend the skin against environmental free radicals.
- Betula Alba Bark Extract (Birch): Known for its calming, purifying, and skin-soothing properties.
Full Ingredients List Aqua (water), Caprylic capric triglyceride, Mineral oil, Glyceryl Stearate, PEG-100 Stearate, Squalane, Propylene glycol, Dimethicone, Dipropylene glycol, Betula alba bark extract, Scrophularia nodosa extract, Retinol, BHT, Tricaprylin, Polymethyl methacrylate, PEG-40 hydrogenated castor oil, Tocopherol, Phenoxyethanol, Ethylhexylglycerin, Cetyl alcohol, Stearyl alcohol, Carbomer, Disodium EDTA.
Free Express Shipping with orders over $199
Available at our Edmonton Boutique
Ship to Canada only
Pickup currently unavailable at Loshen & Crem

Biophora Bioactive Retinol 60
30 ml
Loshen & Crem
5238 Windermere Boulevard
Edmonton AB T6W 0L9
Canada
Returns & Refunds
At Loshen & Crem, we understand that sometimes, even the most carefully chosen product might not be "the one."
- Returns: You have 30 days from delivery to return any unopened and unused products in perfect condition—just as they arrived.
- Refunds: If your return reaches us within 30 days of purchase, you’ll have the choice between a refund or store credit (your preference, naturellement). After 30 days, store credit is your only option. Beyond 40 days, refunds and credits are no longer possible.
Final Sale Items
For transparency, certain items are final sale and not eligible for return or exchange:
- Products on sale
- Products marked “Final markdown” on our online store
- Gift cards
- Promotional kits and deluxe samples
- Limited-edition or seasonal item
Shipping Policy
At Loshen & Crem, we take delivering your skincare treasures très seriously. From Canada to the U.S., we’re here to ensure your beauty cabinet is always well-stocked.
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Free Shipping:
- Canada: Complimentary EXPRESS shipping on orders over $199 CAD (after discounts and before taxes).
- United States: Complimentary EXPRESS shipping on orders over $250 USD. We are temporarily pausing USD payments at the moment. Apologies for the inconvenience, and thank you for your understanding!
- During our annual sales, enjoy free EXPEDITED shipping for orders over $250 CAD (or $350 USD).
- For smaller indulgences, shipping is $24.95 CAD within Canada and $30.95 USD to the U.S.
P.S. We ship to P.O. Boxes via Canada Post—but not during strikes. C’est compliqué.
Processing Time:
We aim to dispatch your order within 2 business days, though peak sales and payment verifications may require a touch more patience.
Please note that if you make any changes with the courier after the dispatch, our carrier will charge a $32 fee. In addition, we will have to withdraw the Free Express shipping option from your SkinSkinGlow points account. We appreciate your understanding.
Our processing time starts from the moment your order is successfully submitted and may take up to 2 business days to dispatch your order. However, please be aware that processing and handling time may be extended during peak sale periods. Before we can ship your order, we may need to hold your order for payment verification and confirm your details with your card issuer.
We will do our very best to minimize delays.
Shipping Rates & Delivery Times
Estimated Delivery Times (Canada):
- British Columbia & Alberta: 1–2 business days
- Manitoba & Saskatchewan: 1–2 business days
- Quebec & Ontario: 1–2 business days
- Atlantic Provinces: 1–3 business days
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United States: Delivery times vary by region:
- Zone 1: Eastern States – 3–4 business days
- Zone 2: Central States – 4–5 business days
- Zone 3: Western States – 5 business days
Remote areas may experience longer shipping times.Please Note: Shipping windows are estimates and not guarantees. Delays may occur due to weather, traffic, or additional verification processes.
Shipping Address Details
For a smooth delivery, please provide all relevant information, including buzzer codes, directional suffixes (North, South, etc.), or special instructions.
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Address Changes: Once your package has left our warehouse, address updates cannot be made. If you need to make changes before dispatch, email us at info@loshen.ca with your order details.
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Carrier Fees: Any changes made with the courier after dispatch will incur a $32 CAD fee, and the Free Express Shipping option will be deducted from your La Crème Points account.
Tracking Your Order
All shipments include tracking information, so you can follow your package from our warehouse to your door. A confirmation email with your tracking number will be sent once your order is dispatched.
Damaged or Lost Packages
- Damaged Parcels: If your order arrives damaged, please contact us at info@loshen.ca with photos and details. We’ll work to resolve the issue promptly.
- Lost or Stolen Packages: If your package is marked "delivered" but hasn’t arrived, please contact the carrier directly to file a claim.
Tips to Avoid Lost or Stolen Packages:
- Opt for a signature upon receipt (required for orders over $350 CAD).
- Have your package delivered to your workplace.
- If you’re not home on the expected delivery date, ask a neighbor to receive your package.
Unclaimed Parcels
If your package is returned to us unclaimed, we’ll issue a refund minus a $24.95 CAD return shipping fee.
Free Samples
We believe every order deserves a little extra care! Expect 1–3 complimentary samples selected by our Skincare Specialists to perfectly complement your order.
Loyalty Rewards: La Crem Points
Earn La Crème Points with every purchase and redeem them for future orders. From time to time, we also offer Free Gifts With Purchase (GWP) for select brands, but these are available only while supplies last.
At Loshen & Crem, we aim to deliver excellence at every step of your skincare journey, with care and a touch of elegance. Questions? Don’t hesitate to reach out—we’re always happy to assist!
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