Biologique Recherche Sérum Vivant

The Microbiome-Balancing Serum for Persistent Blemishes

Biologique Recherche Sérum Vivant is a multi-corrective face serum developed specifically for adult skin prone to persistent blemishes.

Born from the cult legacy of Masque Vivant, this advanced daily formula approaches imperfections as a sign of skin imbalance—not something to be aggressively stripped away.

Its complementary prebiotic-postbiotic technology helps support the skin microbiome while targeting persistent blemishes, associated redness, excess sebum and uneven-looking texture. The skin progressively appears clearer, calmer and more balanced while its protective barrier and comfort are preserved.

Benefits

• Visibly reduces persistent blemishes
• Helps calm redness associated with blemishes
• Regulates excess sebum and visible shine
• Refines uneven-looking texture
• Helps minimize the appearance of enlarged pores
• Supports a balanced skin microbiome
• Reduces transepidermal water loss
• Supports the skin’s protective barrier
• Preserves comfort without excessive dryness
• Suitable for sensitive skin
• Leaves the complexion smoother, clearer and more even-looking

Best For

• Adult skin experiencing persistent or recurring blemishes
• Combination or oily skin with visible redness
• Excess sebum and unwanted shine
• Uneven-looking texture and enlarged pores
• Skin that feels both blemish-prone and sensitive
• Skin experiencing dehydration or barrier fragility alongside imperfections
• Anyone seeking a daily complement to Masque Vivant
• Skin that has become uncomfortable from overly aggressive purifying routines

Why It Is Different

Sérum Vivant is not simply another oil-control or spot-correcting serum.

Adult blemish-prone skin can experience excess sebum, persistent redness, dehydration, sensitivity and barrier fragility at the same time. Treating only the oil—or attempting to dry every imperfection—can leave the complexion more uncomfortable and less resilient.

Sérum Vivant takes a broader approach. Its prebiotic-postbiotic formula helps support the skin ecosystem while visibly correcting persistent blemishes, excess shine, redness and irregular texture.

The objective is not to overpower the skin. It is to help the skin recover its balance.

How It Works

Sérum Vivant combines three complementary biotechnology-derived actives:

• Yeast Extract is the signature postbiotic of the Vivant collection. Derived from the fermentation of Saccharomyces cerevisiae, it is naturally rich in amino acids and bioactive metabolites. It helps support blemish-prone skin and target biological markers associated with blemish-related redness.
• Inulin is a prebiotic polysaccharide that selectively nourishes beneficial microorganisms naturally present on the skin. By supporting microbial diversity and balance, it contributes to skin-barrier function and comfort.
• Polylysine is a fermentation-derived biomimetic biopolymer composed of lysine units. Its structure allows selective interaction with microorganisms associated with blemishes, including Cutibacterium acnes.

Together, these actives create a complementary prebiotic-postbiotic approach: prebiotics nourish beneficial microorganisms while postbiotics provide immediately available bioactive compounds.

Clinically Evaluated Results

With twice-daily application:

• 27% reduction in excess sebum after 14 days
• 19% improvement in the appearance of refined texture after 14 days
• 42% reduction in persistent blemishes after 28 days
• 21% reduction in redness intensity after 28 days
• 19% reduction in transepidermal water loss after 28 days

Sérum Vivant was evaluated under dermatological control on men and women, including participants with sensitive skin.

Results are based on separate instrumental and clinical evaluations involving 19 to 21 participants. Individual results may vary.

The Texture

Sérum Vivant has a slightly viscous, gelled aqueous texture that feels lightweight and silky as it moves across the skin.

It absorbs with a soft, non-greasy finish and does not leave the complexion feeling heavy or occluded.

Its distinctive colour and naturally characteristic scent come from the formula’s yeast-derived actives—an identifiable sensorial signature of the Vivant collection.

The serum is produced using a cold-process method to help preserve the integrity and quality of its active ingredients.

How to Use

1. Apply morning and evening after completing the Biologique Recherche Initialization Phase.
2. Dispense a few drops and apply to the face, neck and décolleté, avoiding the eye area.
3. Gently press or smooth the serum into the skin until absorbed.
4. Follow with any additional prescribed Sérums Authentiques.
5. Finish with the moisturizer selected for your Skin Instant®.
6. Apply broad-spectrum sunscreen every morning.

When combining several Sérums Authentiques, apply Sérum Vivant immediately before Colostrum VG and/or Sérum Spectral.

Complete Biologique Recherche Balancing Protocol

1. Cleanse with the milk selected for your Skin Instant®
2. Apply the appropriate Lotion P50
3. Use Masque Vivant at the frequency recommended by your skin expert
4. Apply Sérum Vivant
5. Layer any additional prescribed Sérums Authentiques
6. Finish with your selected Biologique Recherche cream
7. Apply broad-spectrum sunscreen every morning

Because persistent blemishes are multifactorial, the complete protocol should be personalized according to sensitivity, oil production, redness, dehydration and barrier condition.

Loshen & Crem’s Recommendation

Sérum Vivant is particularly well suited to adult skin experiencing stubborn, recurring blemishes accompanied by redness, shine or sensitivity.

We recommend using it consistently morning and evening rather than treating it only as an occasional spot serum. Its benefits are progressive: the texture begins to appear more refined, excess shine becomes better balanced and persistent blemishes and associated redness visibly improve with continued use.

It is also an important option for someone whose skin feels blemish-prone but no longer tolerates aggressive, overly drying routines.

A clearer-looking complexion should not come at the expense of the skin barrier.

Ingredients

• Yeast Extract: The signature postbiotic of the Vivant collection. Helps support blemish-prone skin and reduce the appearance of blemish-related redness.
• Inulin: A prebiotic polysaccharide that helps nourish beneficial microorganisms and support a balanced skin microbiome.
• Polylysine: A fermentation-derived biomimetic active that selectively interacts with microorganisms associated with blemishes.
• Bacillus Ferment: A biotechnology-derived ferment that complements the formula’s microbiome-focused approach.
• Alteromonas Ferment Extract: A marine-derived fermentation ingredient included within the formula’s supportive complex.
• Lentil Seed Extract: A plant-derived ingredient that complements the serum’s texture-refining care.
• Rose Myrtle Fruit Extract: A botanical ingredient selected for the multi-corrective blemish-care complex.
• Pomegranate Pericarp Extract: A plant-derived extract that supports the formula’s comprehensive approach.
• Mastic Gum: A botanical ingredient traditionally associated with purifying and sebum-balancing skincare.
• Glycerin: Helps attract and retain moisture to preserve skin comfort.
• Propanediol and Pentylene Glycol: Humectant ingredients that support hydration and the serum’s lightweight application.

Full Ingredient List

Ingredients may be updated by the manufacturer. Please refer to the product packaging for the most current ingredient list.

BR Skin Reaction Policy 📄

At Loshen & Crem, we want to ensure you have the best experience possible with our brands. That's why we highly recommend having a consultation with one of our skin experts before purchasing any Biologique Recherche product.

In case of any reaction, they require images of the reaction, product, lot number on the bottom of the box OR product, and proof of an online consultation with one of our skin experts to ensure that they can assist you in the best possible way.

If you decide to purchase without a consultation and experience any reaction, we won't be able to provide a refund. However, we're always here to help you find the best products for your skin and answer any questions, so please don't hesitate to contact us

The Difference Between Purifying and Over-Drying

Purifying the skin does not mean removing every trace of oil.

Sebum is part of the skin’s protective ecosystem. Difficulties arise when excess sebum, irregular keratinization, microbial proliferation and inflammation begin to interact within the follicle.

An overly aggressive routine may temporarily make skin feel less oily, but it can also increase discomfort, dehydration and barrier fragility.

Sérum Vivant takes a more intelligent approach:

• It helps regulate excess sebum rather than attempting to eliminate it
• It supports the skin microbiome rather than indiscriminately disrupting it
• It targets blemish-related redness while preserving comfort
• It improves visible imperfections while supporting barrier integrity

The result is not simply skin that feels drier. It is skin that appears progressively clearer and more balanced.

Sérum Vivant, Complexe Iribiol or Dermopore?

Each serum addresses a different expression of imbalance.

• Complexe Iribiol : is primarily recommended for hyper-seborrheic skin. It helps clear the appearance of active blemishes and reduce oiliness and is often applied more locally.
• Dermopore :  is a pore-refining serum recommended for combination or oily skin presenting enlarged pores. It helps refine visible pores and mattify the T-zone.
• Sérum Vivant : is a multi-corrective serum developed for adult skin experiencing persistent blemishes. It addresses blemishes, associated redness, excess sebum and uneven texture while supporting the skin barrier.

The most appropriate serum should always be selected according to a personalized assessment of the current Skin Instant®.

Frequently Asked Questions

What is Biologique Recherche Sérum Vivant?
Sérum Vivant is a multi-corrective face serum developed for adult skin experiencing persistent blemishes. It helps reduce blemishes, associated redness, excess sebum and uneven texture while supporting the skin microbiome and protective barrier.

Who is Sérum Vivant best for?
It is best suited to adult combination or oily skin experiencing recurring blemishes, visible redness, excess shine, irregular texture or barrier fragility.

Can Sérum Vivant be used on sensitive skin?
Yes. Sérum Vivant is suitable for sensitive skin and was tested under dermatological control on participants that included sensitive skin.

Is Sérum Vivant an acne treatment?
Sérum Vivant is cosmetic skincare for blemish-prone skin. It is not a medical treatment for acne or a substitute for care prescribed by a qualified healthcare professional.

What are the principal ingredients in Sérum Vivant?
The formula’s three central biotechnology-derived actives are Yeast Extract, Inulin and Polylysine.

What is the prebiotic in Sérum Vivant?
Inulin is the formula’s principal prebiotic. It helps nourish beneficial microorganisms naturally present on the skin and support microbial balance.

What is the postbiotic in Sérum Vivant?
Yeast Extract is the Vivant signature postbiotic. It is derived from Saccharomyces cerevisiae fermentation and contains amino acids and bioactive metabolites.

What does Polylysine do in Sérum Vivant?
Polylysine is a biomimetic, fermentation-derived active that selectively interacts with microorganisms associated with blemishes, including Cutibacterium acnes.

How quickly can I expect results?
Clinical evaluations demonstrated reduced excess sebum and more refined-looking texture after 14 days, with visible improvements in persistent blemishes, redness and water loss after 28 days of twice-daily use.

How often should I use Sérum Vivant?
Apply it every morning and evening for consistent results.

At which step should Sérum Vivant be applied?
Apply it after cleansing and Lotion P50 and before your moisturizer. When using multiple Sérums Authentiques, apply Sérum Vivant immediately before Colostrum VG and/or Sérum Spectral.

Can Sérum Vivant be used with Lotion P50?
Yes. Apply the Lotion P50 selected for your Skin Instant® before Sérum Vivant.

Can Sérum Vivant be used with Masque Vivant?
Yes. Sérum Vivant is designed as a daily complement to the cult-favourite Masque Vivant.

What is the difference between Sérum Vivant and Masque Vivant?
Masque Vivant is an intensive treatment mask used periodically. Sérum Vivant is a lightweight, leave-on serum designed for daily morning and evening application.

What is the difference between Sérum Vivant and Complexe Iribiol?
Complexe Iribiol primarily targets hyper-seborrheic skin, active blemishes and oiliness. Sérum Vivant is intended for persistent adult blemishes accompanied by redness, uneven texture or barrier fragility.

What is the difference between Sérum Vivant and Dermopore?
Dermopore primarily targets enlarged pores and T-zone shine. Sérum Vivant offers broader correction of persistent blemishes, associated redness, sebum and texture while supporting the barrier.

Can Sérum Vivant be combined with ISO-Placenta?
Yes. Sérum Vivant may be used to address current persistent blemishes, while ISO-Placenta can be applied as recommended to support the appearance of post-blemish marks.

Does Sérum Vivant dry out the skin?
Sérum Vivant was formulated to reduce excess sebum without aggressive drying. It also helps reduce transepidermal water loss and support the skin barrier.

Does Sérum Vivant help with redness?
Yes. It helps visibly reduce redness associated with persistent blemishes.

Does Sérum Vivant help refine pores?
By reducing excess sebum and improving uneven-looking texture, Sérum Vivant helps the skin surface and visible pores appear more refined.

What does Sérum Vivant feel like?
It has a slightly viscous, gelled aqueous texture with a lightweight, silky glide and a soft, non-greasy finish.

Does Sérum Vivant contain added fragrance?
Fragrance or Parfum is not listed within the official ingredient list. The serum has a distinctive natural scent associated with its yeast-derived actives.

Can men use Sérum Vivant?
Yes. Sérum Vivant was evaluated on both men and women with blemish-prone skin.

What sizes are available?
Sérum Vivant is available in 8 ml and 30 ml formats.

Why Discover Biologique Recherche Sérum Vivant at Loshen & Crem?

Loshen & Crem is an authorized Biologique Recherche retailer and facial studio specializing in skin health, professional skincare and personalized guidance.

Our experienced skin experts can help determine whether Sérum Vivant, Complexe Iribiol or Dermopore is most appropriate for your current Skin Instant® and how to pair it with Lotion P50, Masque Vivant and your treatment cream.

Persistent blemishes rarely need another random active ingredient. They need a thoughtful protocol that considers oil production, sensitivity, redness, hydration and barrier health together.

Shop Sérum Vivant online or connect with Loshen & Crem for personalized Biologique Recherche guidance.