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Le Mieux24 Hr. Age Defying Cream
Why it fits
A Loshen & Crem bestseller for lasting moisture, barrier support and smoother, firmer-looking skin

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Explore La Crem rewardsA cooling, serum-infused sheet mask for immediate hydration, smoother-looking fine lines and renewed luminosity
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Le Mieux
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$50.00 CAD
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The skincare focus
A cooling, serum-infused sheet mask for immediate hydration, smoother-looking fine lines and renewed luminosity
Explore our ingredient glossaryLe Mieux
The ingredients behind this formula—and what they bring to your skin.
Galactomyces Ferment Filtrate
Helps hydrate, condition and promote a more luminous-looking complexion.
Sodium Hyaluronate and Hyaluronic Acid
Attract moisture for a plumper, smoother-looking finish.
Rice Bran Water
Provides a conditioning, antioxidant-rich base.
Ingredient imagery is illustrative. Explore the full ingredient list below.
Made to work together
Explore another step in your face-care routine.
Your routine
A Loshen & Crem bestseller for lasting moisture, barrier support and smoother, firmer-looking skin
Your routine
A nourishing peptide cleanser for soft, supple and comfortably clean skin
Worth knowing
A closer look at your skin, your routine and what goes into the formula.
A cooling, serum-infused sheet mask for immediate hydration, smoother-looking fine lines and renewed luminosity
Le Mieux Bio Cell+ Mask is an award-winning sheet-mask treatment designed to replenish dehydrated, tired-looking skin in 15 to 20 minutes. Each box contains four individually packaged masks saturated with a concentrated blend of hyaluronic acid, peptides, collagen, ferments and magnesium ascorbyl phosphate—a stable vitamin C derivative.
The cooling gel mask helps maintain close contact between the serum and the skin, allowing humectants and conditioning ingredients to deliver an immediate plumping and smoothing effect. Skin appears softer, firmer and more luminous, while the look of dehydration lines and fatigue is temporarily diminished.
Bio Cell+ Mask is especially useful before an event, after travel or whenever the complexion needs a visible hydration reset. Its results are cosmetic: the mask can make skin appear plumper and more lifted through hydration, but it does not permanently tighten the skin or replace lost dermal collagen.
Galactomyces Ferment Filtrate, Sodium Hyaluronate, Oryza Sativa (Rice) Bran Water, Hyaluronic Acid, Lavandula Angustifolia (Lavender) Flower Water, Camellia Sinensis Extract, Collagen, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Magnesium Ascorbyl Phosphate, Panthenol (Vitamin B5), Saxifraga Sarmentosa Extract, Vitis Vinifera (Grape) Seed Extract, Morus Alba Root Extract, Scutellaria Baicalensis Root Extract, Glycyrrhizic Acid, Allantoin, Glucosamine HCI, Laminaria Digitata Extract, Saccharomyces Cerevisiae Extract, Yeast Extract, Fagus Sylvatica Bud Extract, Enteromorpha Compressa Extract, Chitosan, Urea, Pentylene Glycol, Caprylyl Glycol, Propanediol, Ethylhexylglycerin.
Ingredient lists may change. Always refer to the product packaging for the most current ingredient list, particularly if you have allergies or sensitivities. Contact info@loshen.ca if you need help reviewing the formula before purchasing.
For delivery and return information, view our policy.
A cooling, serum-infused sheet mask for immediate hydration, smoother-looking fine lines and renewed luminosity
Le Mieux Bio Cell+ Mask is an award-winning sheet-mask treatment designed to replenish dehydrated, tired-looking skin in 15 to 20 minutes. Each box contains four individually packaged masks saturated with a concentrated blend of hyaluronic acid, peptides, collagen, ferments and magnesium ascorbyl phosphate—a stable vitamin C derivative.
The cooling gel mask helps maintain close contact between the serum and the skin, allowing humectants and conditioning ingredients to deliver an immediate plumping and smoothing effect. Skin appears softer, firmer and more luminous, while the look of dehydration lines and fatigue is temporarily diminished.
Bio Cell+ Mask is especially useful before an event, after travel or whenever the complexion needs a visible hydration reset. Its results are cosmetic: the mask can make skin appear plumper and more lifted through hydration, but it does not permanently tighten the skin or replace lost dermal collagen.
Bio Cell+ Mask is particularly well suited to:
Clients who are highly reactive to aromatic botanical waters should patch test carefully because the formula contains lavender flower water.
Bio Cell+ Mask combines the immediate benefits of a serum-saturated sheet mask with peptides, two forms of hyaluronic acid, collagen, ferments and a stable vitamin C derivative.
The gel mask helps hold the serum against the skin for 15 to 20 minutes, reducing rapid evaporation and encouraging a temporarily plumper, smoother-looking finish. Unlike a clay or exfoliating mask, Bio Cell+ does not focus on absorbing oil or removing surface cells. Its purpose is hydration, conditioning and visible revitalization.
Use after cleansing and toning, in the morning or evening.
Carefully unfold the mask and peel it away from its paper backing. Apply the gel side directly to the face, adjusting the mask around the eyes, nose and mouth.
Leave on for 15 to 20 minutes. Remove and gently press the remaining serum into the face, neck and décolleté. Do not rinse.
The separated gauze layer may be placed over the neck and décolleté to make use of the remaining serum.
Follow with moisturizer to help seal in hydration. Each mask is intended for one application and should be discarded after use.
Bio Cell+ Mask is an excellent treatment when the complexion needs to look rested, hydrated and luminous quickly. Use it the evening before an event or approximately 30 to 60 minutes before makeup application to allow the remaining serum to absorb fully.
Do not leave the mask on overnight. Once a sheet mask begins drying, extending the treatment time does not necessarily produce better results and may become uncomfortable.
For very dry skin, follow with Bio Cell Rejuvenating Cream or another nourishing moisturizer. Combination or oilier skin may prefer a lighter gel-cream after the serum has absorbed.
The formula contains lavender flower water and several botanical extracts. Highly fragrance-reactive skin should patch test before applying the full mask. Because Le Mieux identifies the collagen as marine-derived, clients with fish allergies or ingredient-origin concerns should review the packaging and contact us before use.
There is no need to add an exfoliating mask or peel during the same routine. Keeping the surrounding steps gentle allows the hydrating treatment to remain the focus.
Each Le Mieux mask addresses a different skincare priority.
Bio Cell+ Mask is the most convenient option for travel or occasions when a single-use, serum-intensive treatment is preferred.
Sheet masks create a temporary occlusive environment that helps slow water loss while holding humectants and conditioning ingredients against the skin. As the outermost layers become better hydrated, the complexion can look smoother and fine dehydration lines may become less visible.
Topically applied collagen primarily acts as a moisturizing and film-forming ingredient. It does not replace collagen within the deeper layers of the skin. Its immediate firming effect comes largely from improved hydration and the flexible film it forms on the surface.
Peptides and magnesium ascorbyl phosphate complement these immediate benefits, but a single mask should not be expected to permanently lift the skin or erase wrinkles. Consistent daily skincare—including moisturizer and sunscreen—remains essential for longer-term visible improvement.
Full Ingredient List:
Galactomyces Ferment Filtrate, Sodium Hyaluronate, Oryza Sativa (Rice) Bran Water, Hyaluronic Acid, Lavandula Angustifolia (Lavender) Flower Water, Camellia Sinensis Extract, Collagen, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Magnesium Ascorbyl Phosphate, Panthenol (Vitamin B5), Saxifraga Sarmentosa Extract, Vitis Vinifera (Grape) Seed Extract, Morus Alba Root Extract, Scutellaria Baicalensis Root Extract, Glycyrrhizic Acid, Allantoin, Glucosamine HCI, Laminaria Digitata Extract, Saccharomyces Cerevisiae Extract, Yeast Extract, Fagus Sylvatica Bud Extract, Enteromorpha Compressa Extract, Chitosan, Urea, Pentylene Glycol, Caprylyl Glycol, Propanediol, Ethylhexylglycerin.
Ingredient lists may change. Always refer to the product packaging for the most current ingredient list, particularly if you have allergies or sensitivities. Contact info@loshen.ca if you need help reviewing the formula before purchasing.
Each box contains four individually packaged Bio Cell+ Masks.
Use once or twice weekly or whenever the skin needs additional hydration and radiance. More frequent use may be appropriate if the skin remains comfortable, but daily use is not generally necessary.
Remove the paper backing and apply the gel side directly to the face.
Leave it on for 15 to 20 minutes. Longer application does not necessarily improve the results, and the mask should not be worn overnight.
No. Gently press the remaining serum into the skin and follow with moisturizer if needed.
Le Mieux recommends placing the gauze layer on the neck and décolleté so these areas can benefit from the remaining serum.
No. Each mask is intended for one application and should be discarded after use.
No. Hydration and surface film-forming ingredients can create an immediate plumper, smoother and firmer-looking finish, but they do not permanently lift or tighten the skin.
No. Topical collagen primarily acts as a moisturizing and film-forming ingredient. It does not replace collagen within the deeper layers of the skin.
Yes. It is particularly useful before an event because it helps the complexion appear hydrated, smooth and luminous. Allow the remaining serum to absorb fully before applying makeup.
The mask contains hydrating and conditioning ingredients, but it also includes lavender flower water, ferments and several botanical extracts. Sensitive or fragrance-reactive skin should patch test first.
No parfum or added fragrance is listed in the published ingredient list. However, the formula contains lavender flower water, which may have a naturally aromatic character.
No. The formula contains collagen, which Le Mieux identifies as marine-derived. It also contains chitosan, whose source is not specified in the published ingredient list.
Clients with fish allergies should exercise caution because the product contains marine collagen. The source of the chitosan is not specified. Consult your healthcare provider and contact Loshen & Crem for help reviewing the current packaging before use.
Bio Cell+ Mask is not an exfoliating treatment and can generally be used within routines containing retinol or acids. If the skin is already irritated, dry or over-exfoliated, pause stronger actives and use a simplified hydrating routine.
Only when approved by the professional who performed the procedure. Post-procedure skin can be unusually reactive, and suitability depends on the treatment and the condition of the skin.
The published formula does not list retinoids or salicylic acid. However, pregnancy and breastfeeding considerations are individual, so consult your physician or qualified healthcare provider before introducing a new treatment.
The care behind your order
A few helpful details, before your next delivery.
Track your order01 · Across Canada
$149+Free Regular shipping
$249+Free Priority shipping
CAD · After discounts, before taxes and shipping. Conditions and product exclusions apply.
Canada & U.S. delivery details02 · Close to home
Choose pickup at checkout when available. We’ll let you know when your order is ready.
Speak with our boutique03 · A little reassurance
Request an eligible return within 30 days. Items must be unopened, unused and in their original packaging. Final-sale exclusions apply.
Returns & order support
Helps hydrate, condition and promote a more luminous-looking complexion.
Attract moisture for a plumper, smoother-looking finish.
Provides a conditioning, antioxidant-rich base.
Helps maintain surface moisture, softness and elasticity.
Curious about your ingredients?
Explore La Matière
A little guidance. A more considered routine.
Beautiful formulas are only part of the story. Knowing what belongs in your routine makes all the difference.
Talk through your skin, the products you already use and the questions on your mind with one of our facialists.
Book your consultation Just a product question? Ask us.The care behind your care
From your first question to your next replenishment, there’s a real person here to help.
You don’t need to start over. Bring us your current routine and we’ll help you understand where a new formula fits.
Ask our teamTake our skin questionnaire for a thoughtful starting point, then speak with us if you’d like to explore your recommendations.
Find your starting pointA question about how to use it? Unsure about your next step? You’re welcome to come back to our team for guidance.
We’re here to helpFrom our Edmonton boutique
Discover Le Mieux Bio Cell+ Mask at Loshen & Crem, a skin-health boutique and facial studio in Edmonton, Alberta. Explore the Le Mieux collection online across Canada, or speak with our facialists about how this formula fits into the products you already use.
A little care, to keep.
The guidance you’ll want when you get home: how to use it, what to expect and when to check in. A little reminder, with your team still in reach.