Le Grand Coffret by Biologique Recherche

The pinnacle of Biologique Recherche innovation.
Le Grand Coffret unites two of Biologique Recherche’s most advanced creations — La Grande Crème and Le Grand Sérum — in one extraordinary set. Developed through pioneering epigenetic research, these formulas work in perfect synergy to restore density, smooth wrinkles, and awaken the skin’s innate vitality. Designed for Skin Instants© showing signs of epidermal ageing, this exclusive duo delivers regeneration that goes beyond the surface — for visibly firmer, more radiant, and resilient skin.

What's included:

• La Grande Crème 50ml
• La Grande Crème spatula
• Le Grand Sérum 30ml
• Accessory Miroir de Poche (offert)

Recommended for:

• Skin Instants© showing signs of ageing
• Loss of firmness and elasticity
• Fine lines and wrinkles
  
• Dull or devitalized skin

Benefits:

• Promotes cellular regeneration and strengthens skin architecture
  
• Firms and redefines facial contours
  
• Visibly smooths wrinkles and fine lines
  
• Brightens and evens the complexion
  
• Provides long-lasting antioxidant protection

How to use:

1. After cleansing and applying your Lait and Lotion P50, follow with your Sérums Authentiques.
2. Apply a small amount of La Grande Crème to the face, neck, and décolleté morning and/or evening.
3. Finish with Le Grand Sérum, applying 4–5 drops to the same areas.

Loshen & Crem’s recommendation:

A sublime ritual for those seeking the most elevated form of skin regeneration. We recommend using La Grande Crème at night as a rejuvenating treatment and Le Grand Sérum both morning and evening for continuous protection and radiance. For a complete rejuvenation protocol, pair with Masque Biofixine weekly and Crème Contour Yeux et Lèvres Biofixine for the eyes and lips.

Ingredients:

• EpigenActiv® – Acts on genes linked to skin ageing to stimulate cellular renewal and improve elasticity.
• Telomeractiv© Complex – A blend of 27 antioxidant, anti-wrinkle, and regenerating actives to protect skin longevity.
• Peony Extract – Restores density, suppleness, and structure.
• White Tea and Watercress Extracts – Illuminate and even the complexion.
• Centella Asiatica and Witch Hazel Extracts – Soothe, repair, and boost microcirculation.

Full INCI list – La Grande Crème
WATER (AQUA), OCTYLDODECANOL, CETEARYL ALCOHOL, GLYCERYL STEARATE, BUTYLENE GLYCOL, GLYCERIN, PROPANEDIOL, ALCOHOL DENAT., UNDECANE, BUTYROSPERMUM PARKII (SHEA) BUTTER, PROPYLENE GLYCOL, CETEARETH-20, PENTAERYTHRITYL TETRASTEARATE, SORBITAN STEARATE, CERA ALBA (BEESWAX), CAMELLIA SINENSIS LEAF EXTRACT, PAEONIA ALBIFLORA ROOT EXTRACT, MIMOSA TENUIFLORA BARK EXTRACT, ONOPORDUM ACANTHIUM FLOWER/LEAF/STEM EXTRACT, VITIS VINIFERA (GRAPE) JUICE EXTRACT, JASMINUM GRANDIFLORUM (JASMINE) FLOWER EXTRACT, SAMBUCUS NIGRA FLOWER EXTRACT, TERMINALIA CATAPPA LEAF EXTRACT, SOY ISOFLAVONES, LEPIDIUM SATIVUM SPROUT EXTRACT, HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL, LACTOBACILLUS/WASABIA JAPONICA ROOT FERMENT EXTRACT, PICHIA ANOMALA EXTRACT, ACETYL HEXAPEPTIDE-8, PALMITOYL OLIGOPEPTIDE, HYDROLYZED ROYAL JELLY PROTEIN, PALMITOYL TETRAPEPTIDE-7, ALPHA-GLUCAN OLIGOSACCHARIDE, DECARBOXY CARNOSINE HCL, SODIUM LACTATE, TANNIC ACID, CARUM CARVI (CARAWAY) FRUIT OIL, MENTHA PIPERITA (PEPPERMINT) OIL, CETYL PALMITATE, COCOGLYCERIDES, LECITHIN, HYDROGENATED LECITHIN, MALTODEXTRIN, TOCOPHEROL, CARBOMER, TRIDECANE, POLYSORBATE 80, ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER, TRIETHANOLAMINE, PVP, DISODIUM EDTA, POLYACRYLATE CROSSPOLYMER-6, POLYSORBATE 20, T-BUTYL ALCOHOL, PHENOXYETHANOL, METHYLPROPANEDIOL, ETHYLHEXYLGLYCERIN, CAPRYLHYDROXAMIC ACID, PHENETHYL ALCOHOL, CAPRYLYL GLYCOL, SORBIC ACID, LIMONENE, BENZYL BENZOATE.

Full INCI list – Le Grand Sérum
WATER (AQUA), PROPYLENE GLYCOL, GLYCERIN, PROPANEDIOL, MALTODEXTRIN, HYDROLYZED HAZELNUT PROTEIN, LACTOBACILLUS/WASABIA JAPONICA ROOT FERMENT EXTRACT, PENTYLENE GLYCOL, MYRTUS COMMUNIS LEAF EXTRACT, ALLIUM CEPA (ONION) BULB EXTRACT, COMMIPHORA MYRRHA RESIN EXTRACT, HONEY EXTRACT (MEL EXTRACT), CAMELLIA SINENSIS LEAF EXTRACT, HAMAMELIS VIRGINIANA (WITCH HAZEL) BARK/LEAF EXTRACT, CENTELLA ASIATICA EXTRACT, HYPERICUM PERFORATUM FLOWER/LEAF/STEM EXTRACT, PUNICA GRANATUM PERICARP EXTRACT, HAEMATOCOCCUS PLUVIALIS EXTRACT, HYDROLYZED SOY PROTEIN, HYDROLYZED YEAST PROTEIN, YEAST EXTRACT, SACCHAROMYCES CEREVISIAE EXTRACT, BIOSACCHARIDE GUM-1, ACETYL HEXAPEPTIDE-8, NIACINAMIDE, SODIUM HYALURONATE, LACTIC ACID, SODIUM LACTATE, CITRIC ACID, ALLANTOIN, SERINE, ROYAL JELLY EXTRACT, CARUM CARVI (CARAWAY) SEED OIL, MENTHA PIPERITA (PEPPERMINT) OIL, ACACIA SENEGAL GUM, XANTHAN GUM, CARAMEL, SORBITOL, LECITHIN, 1,2-HEXANEDIOL, TEA-LACTATE, UREA, PHENYLPROPANOL, PHENOXYETHANOL, CAPRYLYL GLYCOL, SODIUM BENZOATE, POTASSIUM SORBATE, LIMONENE.

BR Skin Reaction Policy 📄

At Loshen & Crem, we want to ensure you have the best possible experience with Biologique Recherche. Before purchasing any Biologique Recherche product, we highly recommend booking a consultation with one of our estheticians. Consultations are available virtually through Google Meet or in person at our Edmonton boutique. An appointment is required.

In the event of a reaction, Biologique Recherche requires photos of the reaction and the product, the lot number found on the product or the bottom of the box, and proof of a consultation with one of our estheticians before they can review the concern.

If you choose to purchase without a consultation and experience a reaction, we will be unable to provide a refund. Our team is always happy to answer your questions and help you select the products best suited to your skin.