Your routine
BiophoraCalming Cleanser
Why it fits
A pH-balanced cleanser that keeps the barrier comfortable at a stronger retinol strength.
Biophora Bioactive Retinol 60
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Explore La Crem rewardsBiophora’s 0.5% encapsulated retinol cream, the next step for normal to oily skin that already tolerates retinol well. Evening only.
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Boutique details
Your Edmonton boutique.
5238 Windermere Boulevard
Edmonton AB T6W 0L9
Canada
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Shipping options
Standard free $149 CAD+ · Priority free $249 CAD+ on eligible orders
Standard free $149 CAD+ · Priority upgrade $30 CAD
This item excludes the entire order from free Priority, including orders of $249 CAD or more. The paid upgrade is offered where available.
Delivery details
For delivery in Canada: Standard is $25 CAD below $149 CAD. Priority is $30 CAD below $249 CAD and free from $249 CAD on eligible orders. Adding an item excluded from free Priority removes free Priority for the entire order.
This selected item excludes the entire order from free Priority shipping in Canada. Standard is $25 CAD below $149 CAD and free from $149 CAD. A paid Priority upgrade is $30 CAD where available, including orders of $249 CAD or more.
Thresholds apply after discounts, before taxes and shipping. Product, ground-shipping and destination restrictions may apply. Available services and final charges appear at checkout.
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Selected with care.
Biophora
Bioactive Retinol 60
Your ritual begins with the right choice.
$108.00 CAD
Taxes calculated at checkout.
The skincare focus
Biophora Bioactive Retinol 60
Biophora’s 0.5% encapsulated retinol cream, the next step for normal to oily skin that already tolerates retinol well. Evening only.
Explore our ingredient glossaryBiophora
The formula, explained.
The ingredients behind this formula—and what they bring to your skin.
Encapsulated retinol (0.5%)
An encapsulated form of vitamin A at a higher strength than Retinol 30, released gradually to help the look of persistent tone concerns, deeper lines and texture, with less redness.
Squalane
Hydrates, softens and protects the skin barrier, offsetting the dryness often associated with retinol.
Vitamin E
Tocopherol, an antioxidant that helps soothe the skin and protect it from everyday environmental stress.
Ingredient imagery is illustrative. Explore the full ingredient list below.
Made to work together
Pairs beautifully.
Your routine
BiophoraNight Protection
Why it fits
Biophora’s lightweight barrier cream that seals in hydration overnight, for dry, dehydrated or sensitized skin. The last step of your evening routine.
Worth knowing
The finer details.
A closer look at your skin, your routine and what goes into the formula.
Biophora Bioactive Retinol 60
Biophora’s 0.5% encapsulated retinol cream, the next step for normal to oily skin that already tolerates retinol well. Evening only.
For clients who have completed the Bioactive Retinol 30 protocol and are ready to go further. A higher concentration of encapsulated retinol, released gradually, works on more persistent concerns: the look of stubborn dark spots, deeper lines, congestion and uneven texture. Squalane and vitamin E keep the barrier supported throughout.
Our recommendation: If you would like help deciding whether your skin is ready for this step, we recommend a complimentary virtual consultation with one of our estheticians.
Benefits
- The next step after Retinol 30
- Works on the look of deeper lines and stubborn dark spots
- Smooths the look of texture and congestion
- Gradual-release encapsulated retinol
- Squalane and vitamin E keep the barrier supported
How to use
- Cleanse and dry: In the evening, cleanse and let the skin dry completely. Patch test a discreet area at least 24 hours before your first full application.
- Apply Retinol 60: Even if you already use retinol, start once a week for the first few weeks at this strength, then every other night for a month, then nightly only if your skin stays comfortable.
- Comfort as needed: If your skin feels tight, follow with a gentle hydrating serum or barrier cream.
- SPF every morning: Retinol makes skin more sensitive to the sun. Wear a broad-spectrum sunscreen every day while using it.
Precautions
Full Ingredient List
Aqua (water), Caprylic capric triglyceride, Mineral oil, Glyceryl Stearate, PEG-100 Stearate, Squalane, Propylene glycol, Dimethicone, Dipropylene glycol, Betula alba bark extract, Scrophularia nodosa extract, Retinol, BHT, Tricaprylin, Polymethyl methacrylate, PEG-40 hydrogenated castor oil, Tocopherol, Phenoxyethanol, Ethylhexylglycerin, Cetyl alcohol, Stearyl alcohol, Carbomer, Disodium EDTA.
Shipping & returns
For delivery and return information, view our policy.
Biophora’s 0.5% encapsulated retinol cream, the next step for normal to oily skin that already tolerates retinol well. Evening only.
For clients who have completed the Bioactive Retinol 30 protocol and are ready to go further. A higher concentration of encapsulated retinol, released gradually, works on more persistent concerns: the look of stubborn dark spots, deeper lines, congestion and uneven texture. Squalane and vitamin E keep the barrier supported throughout.
Our recommendation: If you would like help deciding whether your skin is ready for this step, we recommend a complimentary virtual consultation with one of our estheticians.
Key ingredients
- Encapsulated retinol (0.5%): a gradual-release vitamin A for the look of persistent tone concerns, deeper lines and texture
- Squalane: hydrates and softens, offsetting the dryness often associated with retinol
- Vitamin E (tocopherol): an antioxidant that helps soothe and protect
- Birch bark extract (Betula alba): a calming, purifying botanical
How to use
- Patch test first: apply a small amount to a discreet area at least 24 hours before your first full application.
- In the evening, apply a small amount to clean, dry skin.
- Start slowly: even if you already use retinol, apply once a week for the first few weeks when stepping up to this strength.
- Increase to every other night for a month, then nightly only if your skin stays comfortable.
Retinol makes the skin more sensitive to the sun: wear a broad-spectrum SPF every day while using it. Retinol is a form of vitamin A. If you are pregnant, breastfeeding or planning a pregnancy, check with your healthcare provider before use.
Full ingredient list
Aqua (water), Caprylic capric triglyceride, Mineral oil, Glyceryl Stearate, PEG-100 Stearate, Squalane, Propylene glycol, Dimethicone, Dipropylene glycol, Betula alba bark extract, Scrophularia nodosa extract, Retinol, BHT, Tricaprylin, Polymethyl methacrylate, PEG-40 hydrogenated castor oil, Tocopherol, Phenoxyethanol, Ethylhexylglycerin, Cetyl alcohol, Stearyl alcohol, Carbomer, Disodium EDTA.
The care behind your order
From our boutique.
To your door.
A few helpful details, before your next delivery.
Track your orderDelivery
A good thing, on its way.
Delivery details
For delivery in Canada: Standard is $25 CAD below $149 CAD. Priority is $30 CAD below $249 CAD and free from $249 CAD on eligible orders. Adding an item excluded from free Priority removes free Priority for the entire order.
This selected item excludes the entire order from free Priority shipping in Canada. Standard is $25 CAD below $149 CAD and free from $149 CAD. A paid Priority upgrade is $30 CAD where available, including orders of $249 CAD or more.
Thresholds apply after discounts, before taxes and shipping. Product, ground-shipping and destination restrictions may apply. Available services and final charges appear at checkout.
CAD · After discounts, before taxes and shipping. Conditions and product exclusions apply.
Canada & U.S. delivery details02 · Close to home
Collect in Edmonton.
Choose pickup at checkout when available. We’ll let you know when your order is ready.
Speak with our boutique03 · Care you can count on
Here after checkout, too.
Request an eligible return within 30 days. Items must be unopened, unused and in their original packaging. Final-sale exclusions apply.
Returns & order support
Encapsulated retinol (0.5%)
An encapsulated form of vitamin A at a higher strength than Retinol 30, released gradually to help the look of persistent tone concerns, deeper lines and texture, with less redness.
Squalane
Hydrates, softens and protects the skin barrier, offsetting the dryness often associated with retinol.
Vitamin E
Tocopherol, an antioxidant that helps soothe the skin and protect it from everyday environmental stress.
Birch bark extract
Betula alba bark extract, known for its calming and purifying properties.
Curious about your ingredients?
Explore La Matière
Expert guidance. A considered routine.
Your skin.
Our attention.
Beautiful formulas are only part of the story. Knowing what belongs in your routine makes all the difference.
Talk through your skin, the products you already use and the questions on your mind with one of our facialists.
Book a consultation Just a product question? Ask us.Personal guidance, in Edmonton or online.
The care behind your care
A place in your routine.
A team in your corner.
From your first question to your next replenishment, there’s a real person here to help.
01 Make sense of what you already use
You don’t need to start over. Bring us your current routine and we’ll help you understand where a new formula fits.
Ask our team02 Get to know your skin
Take our skin questionnaire for a thoughtful starting point, then speak with us if you’d like to explore your recommendations.
Find your starting point03 Keep the conversation going
A question about how to use it? Unsure about your next step? You’re welcome to come back to our team for guidance.
We’re here to helpFrom our Edmonton boutique
Explore Biophora.
Find your place to begin.
Discover Biophora Bioactive Retinol 60 at Loshen & Crem, a skin-health boutique and facial studio in Edmonton, Alberta. Explore the Biophora collection online across Canada, or speak with our facialists about how this formula fits into the products you already use.
Care, to keep.
Your ritual, beautifully noted.
The guidance you’ll want when you get home: how to use it, what to expect and when to check in. Your reminder, with your team still in reach.