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Osmosis Affirm MD
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Explore La Crem rewardsThe Affirm MD is a next-generation, high-potency lifting serum designed to address the unique structural needs of the face, neck, and décolleté. This sophisticated formula acts as a "liquid architectural support," utilizing a bio-available blend of peptides and phospholipids to visibly firm and redefine sagging contours.
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5238 Windermere Boulevard
Edmonton AB T6W 0L9
Canada
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Standard free $149 CAD+ · Priority free $249 CAD+ on eligible orders
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This item excludes the entire order from free Priority, including orders of $249 CAD or more. The paid upgrade is offered where available.
Delivery details
For delivery in Canada: Standard is $25 CAD below $149 CAD. Priority is $30 CAD below $249 CAD and free from $249 CAD on eligible orders. Adding an item excluded from free Priority removes free Priority for the entire order.
This selected item excludes the entire order from free Priority shipping in Canada. Standard is $25 CAD below $149 CAD and free from $149 CAD. A paid Priority upgrade is $30 CAD where available, including orders of $249 CAD or more.
Thresholds apply after discounts, before taxes and shipping. Product, ground-shipping and destination restrictions may apply. Available services and final charges appear at checkout.
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Osmosis
Affirm MD
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The skincare focus
Osmosis Affirm MD
The Affirm MD is a next-generation, high-potency lifting serum designed to address the unique structural needs of the face, neck, and décolleté. This sophisticated formula acts as a "liquid architectural support," utilizing a bio-available blend of peptides and phospholipids to visibly firm and redefine sagging contours.
Explore our ingredient glossaryOsmosis
The formula, explained.
The ingredients behind this formula—and what they bring to your skin.
Palmitoyl Tripeptide-5
A potent peptide complex that helps visibly firm skin and smooth wrinkles.
Phosphatidylcholine
An advanced delivery system designed for maximum efficacy.
Swertia Chirata Extract
A cutting-edge botanical that helps renew the look of skin and improves the appearance of vertical lines.
Ingredient imagery is illustrative. Explore the full ingredient list below.
Made to work together
Pairs beautifully.
Explore another step in your face-care routine.
Your routine
OsmosisRescue MD Serum
Why it fits
Osmosis Rescue MD is a daily serum for skin that looks stressed or uneven and needs a little more comfort. It helps soften the appearance of redness and supports a smoother, more balanced-looking complexion.
Worth knowing
The finer details.
A closer look at your skin, your routine and what goes into the formula.
Osmosis Affirm MD
The Affirm MD is a next-generation, high-potency lifting serum designed to address the unique structural needs of the face, neck, and décolleté. This sophisticated formula acts as a "liquid architectural support," utilizing a bio-available blend of peptides and phospholipids to visibly firm and redefine sagging contours.
Unlike standard serums, Affirm MD focuses on the look of skin firmness. By delivering a concentrated dose of hydrolyzed collagen and specialized amino acids, it targets the "tech neck" lines and loss of jawline definition that often accompany aging and environmental stress. The result is a complexion that feels immediately tightened and looks remarkably more resilient over time.
Benefits
- Advanced Sculpting: High-performance peptides like Palmitoyl Tripeptide-5 help deliver a visible lifting effect.
- Deep Hydration: Squalane and Apricot Kernel Oil infuse the skin with essential lipids for a smooth, glass-like finish.
- Barrier Fortification: Niacinamide (Vitamin B3) refines skin tone while strengthening the natural defense system against pollutants.
- Immediate Radiance: Botanical extracts and Raspberry Seed Oil provide a nutrient-rich "glow" that lasts throughout the day.
- Structural Support: Proline and Glycine help support smoother, firmer-looking skin.
How to use
- Prepare: Begin by spritzing 3–4 sprays of an Osmosis Activating Mist (Infuse or Boost) onto the face.
- Apply: Dispense 2–3 pumps of Affirm MD into your palm.
- Massage: Warm the serum and massage upward from the décolleté to the neck, then onto the face using firm, lifting motions.
- Optimize: If the product feels too "tacky" or requires more glide, reapply the activating mist as needed. This ensures even delivery of the active ingredients.
Full Ingredient List
Aqua, Ethyl Macadamiate, Prunus Armeniaca (Apricot) Kernel Oil, Coco-Caprylate/Caprate, Glycerin, Pentaerythrityl Tetraisostearate, Phosphatidylcholine, Hydrolyzed Collagen, Maltodextrin, Niacinamide, Squalane, Hydroxypropyl Starch Phosphate, Rinus Idaeus (Raspberry) Seed Oil, Palmitoyl Tripeptide-5, Palmitoyl Tripeptide-1, Palmitoyl Hexapeptide-12, Lysine HCl, Proline, Glycine, Prunus Amydalus Dulcis (Sweet Almond) Oil, Swertia Chirata Leaf Extract, Eucalyptus Globulus Leaf Oil, Zingiber Officinale (Ginger) Root Oil, Leuconostoc /Radish Root Ferment Filtrate, Sodium Stearoyl Glutamate, Lauryl Laurate, Sodium Gluconate, Xanthan Gum, Benzyl Alcohol, Cetearyl Alcohol, Caprylic/Capric Triglyceride, Caprylhydroxamic Acid, Cymbopogon Schoenanthus (Lemongrass) Oil, Propylene Carbonate, Stearalkonium Hectorite, Saccharide Isomerate, Rosa Damascena Flower Oil, Citrus Aurantium Bergamia (Bergamot) Fruit Oil.
Shipping & returns
For delivery and return information, view our policy.
The Affirm MD is a next-generation, high-potency lifting serum designed to address the unique structural needs of the face, neck, and décolleté. This sophisticated formula acts as a "liquid architectural support," utilizing a bio-available blend of peptides and phospholipids to visibly firm and redefine sagging contours.
Unlike standard serums, Affirm MD focuses on the look of skin firmness. By delivering a concentrated dose of hydrolyzed collagen and specialized amino acids, it targets the "tech neck" lines and loss of jawline definition that often accompany aging and environmental stress. The result is a complexion that feels immediately tightened and looks remarkably more resilient over time.
Recommended for:![]()
- Loss of Firmness: Skin showing signs of sagging, particularly along the jawline and neck.
- Textural Rejuvenation: Addressing fine lines and "crepey" texture on the décolleté.
- Environmental Recovery: Stressed skin in need of calming antioxidants and moisture-barrier support.
- Laxity Support: Ideal for those seeking long-term structural support without invasive procedures.
Benefits:
- Advanced Sculpting: High-performance peptides like Palmitoyl Tripeptide-5 help deliver a visible lifting effect.
- Deep Hydration: Squalane and Apricot Kernel Oil infuse the skin with essential lipids for a smooth, glass-like finish.
- Barrier Fortification: Niacinamide (Vitamin B3) refines skin tone while strengthening the natural defense system against pollutants.
- Immediate Radiance: Botanical extracts and Raspberry Seed Oil provide a nutrient-rich "glow" that lasts throughout the day.
- Structural Support: Proline and Glycine help support smoother, firmer-looking skin.
How to use:
- Prepare: Begin by spritzing 3–4 sprays of an Osmosis Activating Mist (Infuse or Boost) onto the face.
- Apply: Dispense 2–3 pumps of Affirm MD into your palm.
- Massage: Warm the serum and massage upward from the décolleté to the neck, then onto the face using firm, lifting motions.
- Optimize: If the product feels too "tacky" or requires more glide, reapply the activating mist as needed. This ensures even delivery of the active ingredients.
Loshen & Crem’s recommendation:
We recommend Affirm MD as an essential "corrective anchor" for any advanced skincare ritual. It is our top recommendation for clients who notice their neck and chest are aging faster than their face. Because Osmosis uses Phosphatidylcholine (a liposomal delivery system), the ingredients are delivered efficiently for a visible lifting effect.
Ingredients:
- Palmitoyl Tripeptide-5: A potent peptide complex that helps visibly firm skin and smooth wrinkles.
- Phosphatidylcholine: An advanced delivery system designed for maximum efficacy.
- Swertia Chirata Extract: A cutting-edge botanical that helps renew the look of skin and improves the appearance of vertical lines.
- Amino Acid Complex (Lysine, Proline, Glycine): Essential nitrogen-rich amino acids that help support skin comfort and the look of elasticity.
Full INCI List: Aqua, Ethyl Macadamiate, Prunus Armeniaca (Apricot) Kernel Oil, Coco-Caprylate/Caprate, Glycerin, Pentaerythrityl Tetraisostearate, Phosphatidylcholine, Hydrolyzed Collagen, Maltodextrin, Niacinamide, Squalane, Hydroxypropyl Starch Phosphate, Rinus Idaeus (Raspberry) Seed Oil, Palmitoyl Tripeptide-5, Palmitoyl Tripeptide-1, Palmitoyl Hexapeptide-12, Lysine HCl, Proline, Glycine, Prunus Amydalus Dulcis (Sweet Almond) Oil, Swertia Chirata Leaf Extract, Eucalyptus Globulus Leaf Oil, Zingiber Officinale (Ginger) Root Oil, Leuconostoc /Radish Root Ferment Filtrate, Sodium Stearoyl Glutamate, Lauryl Laurate, Sodium Gluconate, Xanthan Gum, Benzyl Alcohol, Cetearyl Alcohol, Caprylic/Capric Triglyceride, Caprylhydroxamic Acid, Cymbopogon Schoenanthus (Lemongrass) Oil, Propylene Carbonate, Stearalkonium Hectorite, Saccharide Isomerate, Rosa Damascena Flower Oil, Citrus Aurantium Bergamia (Bergamot) Fruit Oil.
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Delivery details
For delivery in Canada: Standard is $25 CAD below $149 CAD. Priority is $30 CAD below $249 CAD and free from $249 CAD on eligible orders. Adding an item excluded from free Priority removes free Priority for the entire order.
This selected item excludes the entire order from free Priority shipping in Canada. Standard is $25 CAD below $149 CAD and free from $149 CAD. A paid Priority upgrade is $30 CAD where available, including orders of $249 CAD or more.
Thresholds apply after discounts, before taxes and shipping. Product, ground-shipping and destination restrictions may apply. Available services and final charges appear at checkout.
CAD · After discounts, before taxes and shipping. Conditions and product exclusions apply.
Canada & U.S. delivery details02 · Close to home
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Request an eligible return within 30 days. Items must be unopened, unused and in their original packaging. Final-sale exclusions apply.
Returns & order support
Palmitoyl Tripeptide-5
A potent peptide complex that helps visibly firm skin and smooth wrinkles.
Phosphatidylcholine
An advanced delivery system designed for maximum efficacy.
Swertia Chirata Extract
A cutting-edge botanical that helps renew the look of skin and improves the appearance of vertical lines.
Amino Acid Complex (Lysine, Proline, Glycine)
Essential nitrogen-rich amino acids that help support skin comfort and the look of elasticity.
Curious about your ingredients?
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Expert guidance. A considered routine.
Your skin.
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Beautiful formulas are only part of the story. Knowing what belongs in your routine makes all the difference.
Talk through your skin, the products you already use and the questions on your mind with one of our facialists.
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From your first question to your next replenishment, there’s a real person here to help.
01 Make sense of what you already use
You don’t need to start over. Bring us your current routine and we’ll help you understand where a new formula fits.
Ask our team02 Get to know your skin
Take our skin questionnaire for a thoughtful starting point, then speak with us if you’d like to explore your recommendations.
Find your starting point03 Keep the conversation going
A question about how to use it? Unsure about your next step? You’re welcome to come back to our team for guidance.
We’re here to helpFrom our Edmonton boutique
Explore Osmosis.
Find your place to begin.
Discover Osmosis Affirm MD at Loshen & Crem, a skin-health boutique and facial studio in Edmonton, Alberta. Explore the Osmosis collection online across Canada, or speak with our facialists about how this formula fits into the products you already use.
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Your ritual, beautifully noted.
The guidance you’ll want when you get home: how to use it, what to expect and when to check in. Your reminder, with your team still in reach.