Introduction
A silky peptide and ceramide moisturizer for lasting hydration, firmer-looking skin and a supple, dewy finish
Le Mieux Bio Cell Rejuvenating Cream is an award-winning daily moisturizer formulated to replenish normal to dry skin without a heavy or greasy finish. Its silky cream texture combines the Hya10+ Complex, five cosmetic peptides, ceramides and nourishing botanical oils to soften visible fine lines and restore a smoother, more supple appearance.
Ten forms of hyaluronic acid and hyaluronic acid derivatives support hydration across the skin’s surface, while ceramides, squalane, phospholipids and plant-derived emollients help reduce moisture loss and reinforce skin comfort.
Galactomyces ferment filtrate and rice bran water form the base of the formula, complemented by sacha inchi, jojoba, argan, rice bran, evening primrose and rosehip oils. Skin feels conditioned and replenished, with a soft, luminous finish that remains comfortable throughout the day.
Benefits
- Provides immediate and lasting hydration
- Helps soften fine lines emphasized by dehydration
- Supports a smoother, firmer-looking complexion
- Improves the appearance of suppleness and elasticity
- Helps reinforce the skin’s moisture barrier
- Reduces dry, tight or depleted sensations
- Leaves skin feeling soft, conditioned and replenished
- Promotes a healthy-looking, dewy finish
- Combines humectants, ceramides, peptides and botanical oils
- Delivers nourishment without an excessively heavy or greasy feel
- Can be used morning and evening
- Extends comfortably to the neck and décolleté
Best For
Bio Cell Rejuvenating Cream is particularly well suited to:
- Normal to dry skin
- Dehydrated or moisture-depleted skin
- Fine lines and early visible signs of aging
- Loss of suppleness or elasticity
- Dryness associated with seasonal changes
- Dull, tired or devitalized-looking skin
- Skin that feels tight after cleansing
- Clients seeking a nourishing moisturizer with a silky finish
- Mature skin needing additional moisture and comfort
- Skin routines containing potentially drying active treatments
Combination skin may also enjoy the cream during colder weather or as an evening moisturizer. Very oily or congestion-prone skin should begin with a small amount and assess how the richer blend of oils and shea butter feels.
Why It Is Different
Bio Cell Rejuvenating Cream approaches hydration through several complementary ingredient families rather than relying on a single hero ingredient.
The Hya10+ Complex attracts and helps retain moisture. Ceramides, phospholipids, squalane and botanical oils support softness and reduce moisture loss. A five-peptide complex addresses the visible appearance of fine lines and firmness, while antioxidant-rich ferments and plant extracts support a more luminous complexion.
Hya10+ Complex: Ten forms of hyaluronic acid and hyaluronic acid derivatives support hydration, plumpness and skin comfort.
Five-Peptide Complex: Includes Acetyl Hexapeptide-8, Oligopeptide-223, Oligopeptide-225, Palmitoyl Pentapeptide-4 and Palmitoyl Tripeptide-5 to support smoother and firmer-looking skin.
Ceramides EOP and NP: Help replenish barrier-associated lipids and protect against moisture loss.
Squalane: Provides lightweight emollience and supports softness without a greasy residue.
Sacha Inchi Oil: Rich in conditioning fatty acids that help nourish dry or depleted skin.
Galactomyces Ferment Filtrate: Helps condition the skin and promote a brighter, more refined-looking complexion.
Botanical Oil Complex: Jojoba, argan, rice bran, evening primrose and rosehip oils replenish and soften.
Shea Butter: Helps seal in moisture and comfort dry-feeling skin.
How to Use
Use morning and evening after cleansing, toning and applying serum.
Apply a small amount to the face, neck and décolleté. Massage gently until absorbed, using upward motions without pulling or stretching the skin.
In the morning, finish with broad-spectrum sunscreen. In the evening, use as the final step of the routine unless applying a facial oil or another occlusive product.
If layering over several serums, allow each product to absorb before applying the cream. Begin with a small amount—additional product can be pressed onto particularly dry areas as needed.
Loshen & Crem’s Recommendation
Bio Cell Rejuvenating Cream is a beautiful choice for clients who want the comfort of a nourishing cream without the dense finish of a traditional rich moisturizer. It is especially helpful when dehydration makes fine lines appear more pronounced or the complexion looks flat and depleted.
Pair it with TGF-β Booster when visible firmness, fine lines and dehydration are the primary concerns. The serum provides concentrated humectants and peptides, while the cream adds the ceramides, oils and emollients needed to seal in moisture.
For very dry skin, apply a hydrating serum first and press a second light layer of Bio Cell Rejuvenating Cream over the driest areas. More cream is not always better—using a measured amount helps preserve its elegant, non-greasy finish.
The current published ingredient list includes fragrance. Sensitive or fragrance-reactive skin should patch test carefully. The formula also contains argan kernel oil and shea butter, so clients with nut allergies or ingredient sensitivities should review the packaging and contact us before use.
Complete the Le Mieux Rejuvenating Routine
Cleanse: Peptide Foam Cleanser
Prepare: Mist with Iso-Cell Recovery Solution
Treat: Apply TGF-β Booster to the face, neck and décolleté
Moisturize: Seal in hydration with Bio Cell Rejuvenating Cream
Mask: Use Bio Cell+ Mask when additional hydration and luminosity are desired
Protect: Apply broad-spectrum sunscreen every morning
When using retinol or exfoliating acids, Bio Cell Rejuvenating Cream may be applied afterward to support moisture and comfort. Avoid introducing several new active products simultaneously if the skin is already dry or reactive.
Bio Cell Rejuvenating Cream, TGF-β Booster or Hyaluronic Shea Mask?
These products complement one another but perform different roles.
Choose Bio Cell Rejuvenating Cream as a daily moisturizer for lasting hydration, barrier support and a supple, dewy finish.
Choose TGF-β Booster as a concentrated serum when dehydration, early fine lines and loss of visible firmness are the primary concerns. Follow it with moisturizer.
Choose Hyaluronic Shea Mask for richer nourishment, an overnight moisture treatment or extremely dry and rough-feeling areas.
Choose Bio Cell+ Mask for a single-use, serum-intensive treatment before an event, after travel or whenever the complexion needs an immediate hydration boost.
Bio Cell Rejuvenating Cream is the most versatile daily option. TGF-β Booster treats before moisturizing, while Hyaluronic Shea Mask offers a richer, more occlusive treatment.
Hyaluronic Acid, Ceramides and Botanical Oils
These ingredients support hydration differently.
Hyaluronic acid is a humectant. It attracts and holds water, helping the skin appear temporarily plumper and making dehydration lines less visible. Bio Cell Rejuvenating Cream contains ten named forms and derivatives, but this does not mean that each one reaches a separate “layer” of the skin. The performance of the complete formula matters more than the number alone.
Ceramides are lipids naturally associated with the skin barrier. Topical ceramides can help replenish the surface lipid environment and reduce moisture loss, particularly when skin feels dry, tight or depleted.
Squalane, shea butter and botanical oils act primarily as emollients. They soften the spaces between dry surface cells and help create a smoother, more flexible feel.
Together, humectants attract moisture, barrier lipids support retention and emollients improve softness. This combination explains why the cream can provide both immediate comfort and a more supple-looking finish with continued use.
Ingredients
Galactomyces Ferment Filtrate: Helps hydrate, condition and support a brighter-looking complexion.
Hya10+ Complex: Ten forms and derivatives of hyaluronic acid help attract moisture and promote a plumper appearance.
Acetyl Hexapeptide-8: Helps soften the appearance of expression-related fine lines.
Oligopeptide-223 and Oligopeptide-225: Cosmetic peptides that support smoother and firmer-looking skin.
Palmitoyl Pentapeptide-4: Supports a refined, more resilient-looking complexion.
Palmitoyl Tripeptide-5: Helps improve the appearance of firmness and elasticity.
Dipalmitoyl Hydroxyproline: An amino-acid derivative that conditions and supports a smoother-looking surface.
Ceramides EOP and NP: Help support the skin barrier and reduce moisture loss.
Squalane: Provides lightweight nourishment and skin-softening benefits.
Sacha Inchi Oil: Conditions dry or depleted skin with essential fatty acids.
Jojoba and Argan Oils: Nourish and soften while supporting suppleness.
Rice Bran Oil: Provides emollient and antioxidant benefits.
Evening Primrose and Rosehip Oils: Help replenish and condition dry-feeling skin.
Shea Butter: Helps seal in moisture and soften roughness.
Beta-Glucan: Supports hydration and skin comfort.
Grape Seed Extract and Vitamin E: Provide antioxidant and conditioning benefits.
Full Ingredient List:
Galactomyces Ferment Filtrate, Sodium Hyaluronate, Oryza Sativa (Rice) Bran Water, Hyaluronic Acid, Zinc Hydrolyzed Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Sodium Hyaluronate Dimethylsilanol, Sodium Hyaluronate Crosspolymer, C12-13 Alkyl Glyceryl Hydrolyzed Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Ascorbyl Propyl Hyaluronate, Acetyl Hexapeptide-8, Oligopeptide-223, Oligopeptide-225, Dipalmitoyl Hydroxyproline, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-5, Ceramide EOP, Ceramide NP, Squalane, Saccharomyces Lysate Extract, Phospholipids, Glyceryl Polymethacrylate, Simmondsia Chinensis (Jojoba) Seed Oil, Argania Spinosa Kernel Oil, Oryza Sativa (Rice) Bran Oil, Plukenetia Volubilis Seed Oil, Butyrospermum Parkii (Shea) Butter, Cetyl Alcohol, Tocotrienols, Tocopheryl Linoleate, Sodium Carboxymethyl Beta-Glucan, Vitis Vinifera Seed Extract, Oenothera Biennis (Evening Primrose) Oil, Rosa Canina Seed Oil, Hydroxyethylcellulose, Tocopherol, Fragrance, Caprylyl Glycol, Ethylhexylglycerin, Undecylenoyl Glycine, Capryloyl Glycine.
Ingredient lists may change. Always refer to the product packaging for the most current ingredient list, particularly if you have allergies or sensitivities. Contact info@loshen.ca if you need help reviewing the formula before purchasing.
What skin types is Bio Cell Rejuvenating Cream best for?
It is best suited to normal, dry, dehydrated and mature skin. Combination skin may also enjoy it as an evening moisturizer or during colder, drier weather.
Is the cream heavy or greasy?
Le Mieux describes it as a lightweight yet creamy moisturizer with a non-greasy finish. It contains several nourishing oils and shea butter, but the texture is designed to feel silky rather than dense.
Can it be used morning and night?
Yes. Apply it after serum in the morning and evening. Always finish the morning routine with broad-spectrum sunscreen.
How much should I apply?
Begin with a small amount and distribute it evenly across the face, neck and décolleté. Apply an additional light layer only where the skin feels particularly dry.
Does it contain ten forms of hyaluronic acid?
Yes. The current published ingredient list names ten forms or derivatives of hyaluronic acid within the Hya10+ Complex.
Do ten forms of hyaluronic acid hydrate ten separate skin layers?
That claim cannot be assumed from the ingredient list. Different forms can vary in molecular size, skin affinity and film-forming behaviour, but the performance of the complete formula is more important than assigning each form to a specific layer.
Will it remove wrinkles or permanently firm the skin?
No moisturizer can permanently lift the skin or erase wrinkles. Hydration can make fine lines appear softer, while peptides and barrier-supporting ingredients may improve the appearance of smoothness and firmness with consistent use.
Can I use it with TGF-β Booster?
Yes. Apply TGF-β Booster first and follow with Bio Cell Rejuvenating Cream. This combination is particularly well suited to dehydration, fine lines and loss of visible suppleness.
Can I use it with retinol or exfoliating acids?
Yes, provided the skin tolerates the active product. Apply retinol or an exfoliating treatment according to its directions, then follow with Bio Cell Rejuvenating Cream. Pause strong actives if the skin becomes persistently irritated.
Is it suitable for acne-prone skin?
The cream is not an acne treatment and contains several botanical oils and shea butter. Some blemish-prone clients may tolerate it well, while others may prefer a lighter moisturizer. Begin with a small amount and monitor the skin.
Will it clog pores?
The finished formula has not been identified as non-comedogenic on the official product page. Individual responses to richer emollients vary, so congestion-prone skin should introduce it gradually.
Can I wear it under makeup?
Yes. Apply a light, even layer and allow it to absorb before sunscreen and makeup. Using too much moisturizer may contribute to pilling.
Is Bio Cell Rejuvenating Cream fragrance-free?
No. Fragrance is listed in the current published ingredient list. Fragrance-reactive or highly sensitive skin should patch test carefully.
Is it suitable for sensitive skin?
The formula contains barrier-supporting and conditioning ingredients, but it also contains fragrance and multiple botanical oils. Sensitive skin should patch test before regular use.
Can I use it if I have a nut allergy?
The formula contains argan kernel oil and shea butter. Cosmetic reactions and allergy risks vary according to the ingredient and its processing. Consult your healthcare provider and contact Loshen & Crem for help reviewing the current packaging before use.
Can it be used during pregnancy or breastfeeding?
The published formula does not list retinoids or exfoliating acids. However, pregnancy and breastfeeding considerations are individual, so consult your physician or qualified healthcare provider before introducing a new product.
