Your routine
Biologique RechercheLotion P50T
Why it fits
Biologique Recherche’s exfoliating, purifying and balancing lotion for seborrheic Skin Instants. The first step after cleansing.
Biologique Recherche Sérum Grand Millésime
Tax excluded. Shipping calculated at checkout
Your ritual, rewarded 138 estimated La Crem points
Your ritual, rewarded. Choose your La Crem tier to estimate your points.
Estimated on eligible spend before tax, shipping and discounts. Your account confirms the final balance.
Explore La Crem rewardsFatigued, dehydrated or dull skin
A finishing serum for radiance, hydration and smoothness, for skin showing fatigue, dehydration or dullness. One of the last steps of your routine, it brings an instant glow and a rested, luminous look.
Discover the formula & ingredientsPickup in Edmonton
Usually ready in 24 hours
Boutique details
Your Edmonton boutique.
5238 Windermere Boulevard
Edmonton AB T6W 0L9
Canada
Wait for your ready-for-pickup email before visiting.
Visit the boutiqueNeed expert guidance?
Let’s talk about your skin and what belongs in your routine.
From our boutique to your door
Shipping, on usRegular $149+ · Priority $249+ CAD
A little discoveryComplimentary samples with every order
30-day returnsUnopened products · View policy
On its way to youTrack your order
Selected with care.
Biologique Recherche
Sérum Grand Millésime
Your ritual begins with the right choice.
$138.00 CAD
Taxes calculated at checkout.
The skincare focus
An instant glow boost to finish your routine.
A finishing serum for radiance, hydration and smoothness, for skin showing fatigue, dehydration or dullness. One of the last steps of your routine, it brings an instant glow and a rested, luminous look.
Explore our ingredient glossaryBiologique Recherche
The formula, explained.
The ingredients behind this formula—and what they bring to your skin.
Cucumis Sativus (Cucumber) Fruit Extract & Hamamelis Virginiana (Witch Hazel) Extract
Botanical extracts that bring a fresh, toning feel to the skin.
Hydrolyzed Silk
Helps soften and smooth the skin.
Lactic Acid & Gluconolactone
Help smooth the look of the skin's texture and support a more luminous complexion.
Ingredient imagery is illustrative. Explore the full ingredient list below.
Made to work together
Pairs beautifully.
Cleanse with the milk selected for your Skin Instant and apply the Lotion P50 selected for your Skin Instant, then the serums and cream chosen for you. Sérum Grand Millésime comes in as one of the last steps. In the morning, finish with sunscreen and avoid sun exposure directly after application.
Your routine
Biologique RechercheCrème Grand Millésime
Why it fits
The cream step of the routine, applied after Lotion P50 and your Quintessential Serums to hydrate and bring radiance to the complexion.
Worth knowing
The finer details.
A closer look at your skin, your routine and what goes into the formula.
Biologique Recherche Sérum Grand Millésime
A true beauty elixir, Biologique Recherche Sérum Grand Millésime is the finishing touch to your skincare routine, designed to brighten, hydrate and smooth the skin while helping preserve its natural defenses.
This global serum for visible signs of aging works beyond hydration: it helps revitalize tired-looking skin, bringing immediate radiance and a rested, luminous appearance.
Ideal for seasonal transitions or periods of fatigue, Sérum Grand Millésime infuses the skin with hydrating, antioxidant and conditioning ingredients for a visibly fresher, more radiant-looking complexion.
Why we love it
Sérum Grand Millésime is the finishing serum we suggest when a client wants to elevate their routine with an extra layer of hydration, radiance and antioxidant protection. We especially like it as a revitalizing course at the change of seasons or after a tiring stretch, when the skin looks dull and needs a glow boost. It is highly concentrated, so we ask clients to expect possible mild redness at first and to keep it away from the eye area.
Benefits
- Brightens and evens the look of the complexion
- Smooths and tones the epidermis for a revitalized appearance
- Helps preserve the skin's natural defenses with antioxidants
- Hydrates the top layers of the epidermis while enhancing suppleness and glow
- A perfect final step in any Biologique Recherche routine
Best for
Fatigued, dehydrated or dull skin
Plan it as a course when the seasons change or you are run down, and skip it right after a deep exfoliation.
How to use
- Complete the earlier steps of your Biologique Recherche routine selected for your Skin Instant.
- Apply a few drops to the face, neck and décolleté in the morning and/or evening, as one of the last steps of your routine.
- Do not apply to the eye area.
- Avoid sun exposure directly after application, and apply a broad-spectrum sunscreen in the morning.
- Use it as a revitalizing course at the change of seasons or during periods of fatigue.
- Do not use immediately after a deep exfoliation. Not suitable for children.
Precautions
Full Ingredient List
WATER (AQUA), PROPYLENE GLYCOL, GLYCERIN, CUCUMIS SATIVUS (CUCUMBER) FRUIT EXTRACT, ACACIA SENEGAL GUM, HYDROLYZED SILK, NIACINAMIDE, MAGNESIUM CHLORIDE, MYRTUS COMMUNIS LEAF EXTRACT, ALLIUM CEPA (ONION) BULB EXTRACT, COMMIPHORA MYRRHA RESIN EXTRACT, HAMAMELIS VIRGINIANA (WITCH HAZEL) BARK/LEAF EXTRACT, HYPERICUM PERFORATUM FLOWER/LEAF/STEM EXTRACT, SOPHORA JAPONICA FLOWER EXTRACT, YEAST EXTRACT, RHIZOBIAN GUM, GLUCONOLACTONE, LACTIC ACID, SODIUM LACTATE, SALICYLIC ACID, CITRIC ACID, ALLANTOIN, SERINE, PYRIDOXINE HCL, THIAMINE HCL, VINEGAR (ACETUM), SORBITOL, CARAMEL, ALCOHOL DENAT., TEA-LACTATE, PROPANEDIOL, UREA, SODIUM BENZOATE, POTASSIUM SORBATE, SODIUM BISULFITE.
Frequently Asked Questions
Who is Sérum Grand Millésime for?
Skin showing signs of fatigue, dehydration or dullness. It is ideal for mature skin or anyone looking for an instant glow boost and enhanced skin resilience.
When should I apply it?
In the morning and/or evening, as one of the last steps of your Biologique Recherche routine.
Can I use it all year?
It is especially recommended as a revitalizing course at the change of seasons or during periods of fatigue.
Is redness normal?
It is a highly concentrated product, so mild redness may appear during the first applications. If irritation persists, discontinue use.
Are there any precautions?
Do not apply to the eye area, do not use immediately after a deep exfoliation, avoid sun exposure directly after application, and keep it away from children: it is not suitable for them.
I have allergies. Who can I ask?
Contact us at info@loshen.ca before purchasing. Our team will be happy to help verify the most current ingredient list for you.
Consultation & reactions
At Loshen & Crem, we want to ensure you have the best possible experience with Biologique Recherche. Before purchasing any Biologique Recherche product, we highly recommend booking a consultation with one of our estheticians. Consultations are available virtually through Google Meet or in person at our Edmonton boutique. An appointment is required.
In the event of a reaction, Biologique Recherche requires photos of the reaction and the product, the lot number found on the product or the bottom of the box, and proof of a consultation with one of our estheticians before they can review the concern.
If you choose to purchase without a consultation and experience a reaction, we will be unable to provide a refund. Our team is always happy to answer your questions and help you select the products best suited to your skin.
Shipping & returns
For delivery and return information, view our policy.
A true beauty elixir, Biologique Recherche Sérum Grand Millésime is the finishing touch to your skincare routine, designed to brighten, hydrate and smooth the skin while helping preserve its natural defenses.
This global serum for visible signs of aging works beyond hydration: it helps revitalize tired-looking skin, bringing immediate radiance and a rested, luminous appearance.
Ideal for seasonal transitions or periods of fatigue, Sérum Grand Millésime infuses the skin with hydrating, antioxidant and conditioning ingredients for a visibly fresher, more radiant-looking complexion.
Benefits
- Brightens and evens the look of the complexion
- Smooths and tones the epidermis for a revitalized appearance
- Helps preserve the skin's natural defenses with antioxidants
- Hydrates the top layers of the epidermis while enhancing suppleness and glow
- A perfect final step in any Biologique Recherche routine
How to use
- Complete the earlier steps of your Biologique Recherche routine selected for your Skin Instant.
- Apply a few drops to the face, neck and décolleté in the morning and/or evening, as one of the last steps of your routine.
- Do not apply to the eye area.
- Avoid sun exposure directly after application, and apply a broad-spectrum sunscreen in the morning.
- Use it as a revitalizing course at the change of seasons or during periods of fatigue.
- Do not use immediately after a deep exfoliation. Not suitable for children.
Ingredients
WATER (AQUA), PROPYLENE GLYCOL, GLYCERIN, CUCUMIS SATIVUS (CUCUMBER) FRUIT EXTRACT, ACACIA SENEGAL GUM, HYDROLYZED SILK, NIACINAMIDE, MAGNESIUM CHLORIDE, MYRTUS COMMUNIS LEAF EXTRACT, ALLIUM CEPA (ONION) BULB EXTRACT, COMMIPHORA MYRRHA RESIN EXTRACT, HAMAMELIS VIRGINIANA (WITCH HAZEL) BARK/LEAF EXTRACT, HYPERICUM PERFORATUM FLOWER/LEAF/STEM EXTRACT, SOPHORA JAPONICA FLOWER EXTRACT, YEAST EXTRACT, RHIZOBIAN GUM, GLUCONOLACTONE, LACTIC ACID, SODIUM LACTATE, SALICYLIC ACID, CITRIC ACID, ALLANTOIN, SERINE, PYRIDOXINE HCL, THIAMINE HCL, VINEGAR (ACETUM), SORBITOL, CARAMEL, ALCOHOL DENAT., TEA-LACTATE, PROPANEDIOL, UREA, SODIUM BENZOATE, POTASSIUM SORBATE, SODIUM BISULFITE.
Skin Reaction Policy
At Loshen & Crem, we want to ensure you have the best possible experience with Biologique Recherche. Before purchasing any Biologique Recherche product, we highly recommend booking a consultation with one of our estheticians. Consultations are available virtually through Google Meet or in person at our Edmonton boutique. An appointment is required.
In the event of a reaction, Biologique Recherche requires photos of the reaction and the product, the lot number found on the product or the bottom of the box, and proof of a consultation with one of our estheticians before they can review the concern.
If you choose to purchase without a consultation and experience a reaction, we will be unable to provide a refund. Our team is always happy to answer your questions and help you select the products best suited to your skin.
The care behind your order
From our boutique.
To your door.
A few helpful details, before your next delivery.
Track your order01 · Across Canada
A good thing, on its way.
$149+Free Regular shipping
$249+Free Priority shipping
CAD · After discounts, before taxes and shipping. Conditions and product exclusions apply.
Canada & U.S. delivery details02 · Close to home
Collect in Edmonton.
Choose pickup at checkout when available. We’ll let you know when your order is ready.
Speak with our boutique03 · A little reassurance
Here after checkout, too.
Request an eligible return within 30 days. Items must be unopened, unused and in their original packaging. Final-sale exclusions apply.
Returns & order support
Cucumis Sativus (Cucumber) Fruit Extract & Hamamelis Virginiana (Witch Hazel) Extract
Botanical extracts that bring a fresh, toning feel to the skin.
Hydrolyzed Silk
Helps soften and smooth the skin.
Lactic Acid & Gluconolactone
Help smooth the look of the skin's texture and support a more luminous complexion.
Vinegar (Acetum), Commiphora Myrrha, Myrtus Communis & Allium Cepa (Onion) Extracts
Included in the formula's antioxidant complex.
Yeast Extract & Niacinamide
Help condition the skin and support its natural barrier.
Curious about your ingredients?
Explore La Matière
A little guidance. A more considered routine.
Your skin.
Our attention.
Beautiful formulas are only part of the story. Knowing what belongs in your routine makes all the difference.
Talk through your skin, the products you already use and the questions on your mind with one of our facialists.
Book a consultation Just a product question? Ask us.Personal guidance, in Edmonton or online.
The care behind your care
A place in your routine.
A team in your corner.
From your first question to your next replenishment, there’s a real person here to help.
01 Make sense of what you already use
You don’t need to start over. Bring us your current routine and we’ll help you understand where a new formula fits.
Ask our team02 Get to know your skin
Take our skin questionnaire for a thoughtful starting point, then speak with us if you’d like to explore your recommendations.
Find your starting point03 Keep the conversation going
A question about how to use it? Unsure about your next step? You’re welcome to come back to our team for guidance.
We’re here to helpFrom our Edmonton boutique
Explore Biologique Recherche.
Find your place to begin.
Discover Biologique Recherche Sérum Grand Millésime at Loshen & Crem, a skin-health boutique and facial studio in Edmonton, Alberta. Explore the Biologique Recherche collection online across Canada, or speak with our facialists about how this formula fits into the products you already use.
A little care, to keep.
Your ritual, beautifully noted.
The guidance you’ll want when you get home: how to use it, what to expect and when to check in. A little reminder, with your team still in reach.