Your routine
Biologique RechercheLa Grande Crème
Why it fits
Our estheticians love Le Grand Sérum layered over La Grande Crème: the cream goes on first, then 4 to 5 drops of the serum as the final step.
Biologique Recherche Le Grand Sérum
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Biologique Recherche's beautifying face elixir for skin showing visible signs of aging. A finishing serum applied as the very last step to help visibly smooth fine lines and wrinkles, firm the look of the skin and revive radiance.
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Boutique details
Your Edmonton boutique.
5238 Windermere Boulevard
Edmonton AB T6W 0L9
Canada
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Shipping, on usRegular $149+ · Priority $249+ CAD
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Selected with care.
Biologique Recherche
Le Grand Sérum
Your ritual begins with the right choice.
$285.00 CAD
Taxes calculated at checkout.
The skincare focus
The finishing touch for fine lines, firmness and radiance.
Biologique Recherche's beautifying face elixir for skin showing visible signs of aging. A finishing serum applied as the very last step to help visibly smooth fine lines and wrinkles, firm the look of the skin and revive radiance.
Explore our ingredient glossaryBiologique Recherche
The formula, explained.
The ingredients behind this formula—and what they bring to your skin.
Niacinamide
A form of vitamin B3 that helps skin look smoother and more even.
Acetyl Hexapeptide-8
A peptide included to help soften the look of expression lines.
Sodium Hyaluronate
A form of hyaluronic acid that hydrates the upper layers of the epidermis.
Ingredient imagery is illustrative. Explore the full ingredient list below.
Made to work together
Pairs beautifully.
Cleanse with the milk selected for your Skin Instant and apply the Lotion P50 selected for your Skin Instant. Follow with your serums and your cream, such as La Grande Crème, then finish with 4 to 5 drops of Le Grand Sérum. In the morning, add sunscreen.
Your routine
Biologique RechercheLotion P50T
Why it fits
Biologique Recherche’s exfoliating, purifying and balancing lotion for seborrheic Skin Instants. The first step after cleansing.
Worth knowing
The finer details.
A closer look at your skin, your routine and what goes into the formula.
Biologique Recherche Le Grand Sérum
Biologique Recherche Le Grand Sérum is the brand's beautifying elixir for the face, created for skin that is beginning to show visible signs of aging: fine lines and wrinkles, a loss of firmness and a dull-looking complexion.
Its formula is concentrated in 27 active ingredients chosen for their smoothing, antioxidant and firming roles. With regular use, wrinkles look visibly reduced, the skin looks firmer and the complexion looks more radiant.
Le Grand Sérum is a finishing serum: it is applied as the very last step of your Biologique Recherche routine, over your cream.
Why we love it
Our estheticians love Le Grand Sérum layered over La Grande Crème: the cream goes on first, then a few drops of the serum to finish. It is the step we suggest when someone wants their routine to address fine lines, firmness and radiance all at once. Because it is a finishing serum, it does not replace anything; it simply completes the routine. If you have a nut allergy or very reactive skin, we would rather see you for a consultation first.
Benefits
- Helps visibly reduce the look of fine lines and wrinkles
- Helps skin look firmer and more toned
- Helps the complexion look more radiant
- Hydrates the upper layers of the epidermis
- Antioxidant ingredients help protect skin from environmental stressors
Best for
Visible signs of aging
Apply La Grande Crème first, then press 4 to 5 drops of Le Grand Sérum over it as your final step.
How to use
- Complete your Biologique Recherche routine first: cleanse, apply the Lotion P50 selected for your Skin Instant, then your serums and cream.
- Apply 4 to 5 drops to the entire face, neck and décolleté, morning and/or evening, as the final step.
- Avoid contact with the eyes.
- In the morning, finish with a broad-spectrum sunscreen.
- For external use only.
Precautions
Full Ingredient List
WATER (AQUA), PROPYLENE GLYCOL, GLYCERIN, PROPANEDIOL, MALTODEXTRIN, HYDROLYZED HAZELNUT PROTEIN, LACTOBACILLUS/WASABIA JAPONICA ROOT FERMENT EXTRACT, PENTYLENE GLYCOL, CARVONE, MENTHOL, MYRTUS COMMUNIS LEAF EXTRACT, ALLIUM CEPA (ONION) BULB EXTRACT, COMMIPHORA MYRRHA RESIN EXTRACT, HONEY EXTRACT (MEL EXTRACT), CAMELLIA SINENSIS LEAF EXTRACT, HAMAMELIS VIRGINIANA (WITCH HAZEL) BARK/LEAF EXTRACT, CENTELLA ASIATICA EXTRACT, HYPERICUM PERFORATUM FLOWER/LEAF/STEM EXTRACT, PUNICA GRANATUM PERICARP EXTRACT, HAEMATOCOCCUS PLUVIALIS EXTRACT, HYDROLYZED SOY PROTEIN, HYDROLYZED YEAST PROTEIN, YEAST EXTRACT, SACCHAROMYCES CEREVISIAE EXTRACT, BIOSACCHARIDE GUM-1, ACETYL HEXAPEPTIDE-8, NIACINAMIDE, SODIUM HYALURONATE, LACTIC ACID, SODIUM LACTATE, CITRIC ACID, ALLANTOIN, SERINE, ROYAL JELLY EXTRACT, CARUM CARVI (CARAWAY) FRUIT OIL, MENTHA PIPERITA (PEPPERMINT) OIL, ACACIA SENEGAL GUM, XANTHAN GUM, CARAMEL, HYDROGENATED STARCH HYDROLYSATE, LECITHIN, 1,2-HEXANEDIOL, TEA-LACTATE, UREA, PHENYLPROPANOL, PHENOXYETHANOL, CAPRYLYL GLYCOL, SODIUM BENZOATE, POTASSIUM SORBATE, LIMONENE.
Frequently Asked Questions
When should I apply Le Grand Sérum?
As the very last step of your Biologique Recherche routine, morning and/or evening, after your cream.
How much should I use?
4 to 5 drops over the entire face, neck and décolleté.
Can I use it with La Grande Crème?
Yes. Our estheticians love it layered over La Grande Crème: apply the cream first, then finish with 4 to 5 drops of the serum. You'll find both together in Le Grand Coffret.
Does it contain nuts?
Yes. Le Grand Sérum contains hazelnut protein and peppermint oil. If you have a nut allergy or very reactive skin, please book a consultation with one of our estheticians before purchasing.
Who is it for?
Skin Instants showing visible signs of aging: fine lines and wrinkles, a loss of firmness and a dull-looking complexion.
I have allergies. Who can I ask?
Contact us at info@loshen.ca before purchasing. Our team will be happy to help verify the most current ingredient list for you.
Consultation & reactions
At Loshen & Crem, we want to ensure you have the best possible experience with Biologique Recherche. Before purchasing any Biologique Recherche product, we highly recommend booking a consultation with one of our estheticians. Consultations are available virtually through Google Meet or in person at our Edmonton boutique. An appointment is required.
In the event of a reaction, Biologique Recherche requires photos of the reaction and the product, the lot number found on the product or the bottom of the box, and proof of a consultation with one of our estheticians before they can review the concern.
If you choose to purchase without a consultation and experience a reaction, we will be unable to provide a refund. Our team is always happy to answer your questions and help you select the products best suited to your skin.
Shipping & returns
For delivery and return information, view our policy.
Biologique Recherche Le Grand Sérum is the brand's beautifying elixir for the face, created for skin that is beginning to show visible signs of aging: fine lines and wrinkles, a loss of firmness and a dull-looking complexion.
Its formula is concentrated in 27 active ingredients chosen for their smoothing, antioxidant and firming roles. With regular use, wrinkles look visibly reduced, the skin looks firmer and the complexion looks more radiant.
Le Grand Sérum is a finishing serum: it is applied as the very last step of your Biologique Recherche routine, over your cream.
Benefits
- Helps visibly reduce the look of fine lines and wrinkles
- Helps skin look firmer and more toned
- Helps the complexion look more radiant
- Hydrates the upper layers of the epidermis
- Antioxidant ingredients help protect skin from environmental stressors
How to use
- Complete your Biologique Recherche routine first: cleanse, apply the Lotion P50 selected for your Skin Instant, then your serums and cream.
- Apply 4 to 5 drops to the entire face, neck and décolleté, morning and/or evening, as the final step.
- Avoid contact with the eyes.
- In the morning, finish with a broad-spectrum sunscreen.
- For external use only.
Ingredients
WATER (AQUA), PROPYLENE GLYCOL, GLYCERIN, PROPANEDIOL, MALTODEXTRIN, HYDROLYZED HAZELNUT PROTEIN, LACTOBACILLUS/WASABIA JAPONICA ROOT FERMENT EXTRACT, PENTYLENE GLYCOL, CARVONE, MENTHOL, MYRTUS COMMUNIS LEAF EXTRACT, ALLIUM CEPA (ONION) BULB EXTRACT, COMMIPHORA MYRRHA RESIN EXTRACT, HONEY EXTRACT (MEL EXTRACT), CAMELLIA SINENSIS LEAF EXTRACT, HAMAMELIS VIRGINIANA (WITCH HAZEL) BARK/LEAF EXTRACT, CENTELLA ASIATICA EXTRACT, HYPERICUM PERFORATUM FLOWER/LEAF/STEM EXTRACT, PUNICA GRANATUM PERICARP EXTRACT, HAEMATOCOCCUS PLUVIALIS EXTRACT, HYDROLYZED SOY PROTEIN, HYDROLYZED YEAST PROTEIN, YEAST EXTRACT, SACCHAROMYCES CEREVISIAE EXTRACT, BIOSACCHARIDE GUM-1, ACETYL HEXAPEPTIDE-8, NIACINAMIDE, SODIUM HYALURONATE, LACTIC ACID, SODIUM LACTATE, CITRIC ACID, ALLANTOIN, SERINE, ROYAL JELLY EXTRACT, CARUM CARVI (CARAWAY) FRUIT OIL, MENTHA PIPERITA (PEPPERMINT) OIL, ACACIA SENEGAL GUM, XANTHAN GUM, CARAMEL, HYDROGENATED STARCH HYDROLYSATE, LECITHIN, 1,2-HEXANEDIOL, TEA-LACTATE, UREA, PHENYLPROPANOL, PHENOXYETHANOL, CAPRYLYL GLYCOL, SODIUM BENZOATE, POTASSIUM SORBATE, LIMONENE.
Skin Reaction Policy
At Loshen & Crem, we want to ensure you have the best possible experience with Biologique Recherche. Before purchasing any Biologique Recherche product, we highly recommend booking a consultation with one of our estheticians. Consultations are available virtually through Google Meet or in person at our Edmonton boutique. An appointment is required.
In the event of a reaction, Biologique Recherche requires photos of the reaction and the product, the lot number found on the product or the bottom of the box, and proof of a consultation with one of our estheticians before they can review the concern.
If you choose to purchase without a consultation and experience a reaction, we will be unable to provide a refund. Our team is always happy to answer your questions and help you select the products best suited to your skin.
The care behind your order
From our boutique.
To your door.
A few helpful details, before your next delivery.
Track your order01 · Across Canada
A good thing, on its way.
$149+Free Regular shipping
$249+Free Priority shipping
CAD · After discounts, before taxes and shipping. Conditions and product exclusions apply.
Canada & U.S. delivery details02 · Close to home
Collect in Edmonton.
Choose pickup at checkout when available. We’ll let you know when your order is ready.
Speak with our boutique03 · A little reassurance
Here after checkout, too.
Request an eligible return within 30 days. Items must be unopened, unused and in their original packaging. Final-sale exclusions apply.
Returns & order support
Niacinamide
A form of vitamin B3 that helps skin look smoother and more even.
Acetyl Hexapeptide-8
A peptide included to help soften the look of expression lines.
Sodium Hyaluronate
A form of hyaluronic acid that hydrates the upper layers of the epidermis.
Centella Asiatica Extract
A botanical extract that helps skin feel comfortable.
Royal Jelly Extract & Hydrolyzed Hazelnut Protein
Help condition the skin and leave it feeling soft.
Curious about your ingredients?
Explore La Matière
A little guidance. A more considered routine.
Your skin.
Our attention.
Beautiful formulas are only part of the story. Knowing what belongs in your routine makes all the difference.
Talk through your skin, the products you already use and the questions on your mind with one of our facialists.
Book a consultation Just a product question? Ask us.Personal guidance, in Edmonton or online.
The care behind your care
A place in your routine.
A team in your corner.
From your first question to your next replenishment, there’s a real person here to help.
01 Make sense of what you already use
You don’t need to start over. Bring us your current routine and we’ll help you understand where a new formula fits.
Ask our team02 Get to know your skin
Take our skin questionnaire for a thoughtful starting point, then speak with us if you’d like to explore your recommendations.
Find your starting point03 Keep the conversation going
A question about how to use it? Unsure about your next step? You’re welcome to come back to our team for guidance.
We’re here to helpFrom our Edmonton boutique
Explore Biologique Recherche.
Find your place to begin.
Discover Biologique Recherche Le Grand Sérum at Loshen & Crem, a skin-health boutique and facial studio in Edmonton, Alberta. Explore the Biologique Recherche collection online across Canada, or speak with our facialists about how this formula fits into the products you already use.
A little care, to keep.
Your ritual, beautifully noted.
The guidance you’ll want when you get home: how to use it, what to expect and when to check in. A little reminder, with your team still in reach.