Le Mieux 24 HR. Age Defying cream

A Loshen & Crem bestseller for lasting moisture, barrier support and smoother, firmer-looking skin

Le Mieux 24 Hr. Age Defying Cream is a rich yet non-greasy moisturizer created for dry, mature and visibly depleted skin. Its multi-dimensional formula combines ten forms of hyaluronic acid with peptides, ceramides, squalane, cupuaçu butter, shea butter and kukui seed oil to replenish moisture and restore a smoother, more resilient appearance.

Designed to provide intense hydration for up to 24 hours, the cream addresses the tightness, roughness and crepey-looking texture that can become more noticeable with age, seasonal dryness or a depleted moisture barrier. It is particularly effective across the neck and décolleté, where the skin often requires more sustained nourishment.

There is a reason this is one of Loshen & Crem’s top-selling moisturizers: it provides the comfort of a genuinely rich cream while maintaining an elegant finish that does not feel excessively heavy or greasy.

Benefits

• Delivers intense, lasting hydration for up to 24 hours
• Helps strengthen and support the skin’s moisture barrier
• Softens the appearance of fine lines and wrinkles
• Improves the look of firmness and resiliency
• Helps smooth crepey-looking texture on the face and neck
• Reduces dry, tight or weathered sensations
• Supports a softer and more supple complexion
• Replenishes skin with ceramides, squalane and botanical lipids
• Helps seal in moisture throughout the day or night
• Promotes a smoother, more comfortable skin surface
• Nourishes mature and moisture-depleted skin
• Provides a rich texture without an excessively greasy finish
• Can be used morning and evening

Best For

24 Hr. Age Defying Cream is particularly well suited to:

• Dry or very dry skin
• Mature or visibly aging skin
• Fine lines and wrinkles
• Loss of firmness or resiliency
• Crepey-looking texture
• Dryness across the neck and décolleté
• Skin that feels tight or depleted
• Seasonal or weather-related dryness
• Skin experiencing reduced suppleness
• Normal skin needing a richer winter moisturizer
• Routines containing potentially drying active treatments
• Clients seeking a nourishing cream without a balm-like finish

Combination skin may prefer it as an evening moisturizer or concentrated neck cream. Very oily or congestion-prone skin may find the rich blend of butters and oils more than it needs.

Why It Is Different

24 Hr. Age Defying Cream combines humectants, barrier lipids, emollients, peptides and antioxidants in one formula. This layered approach allows it to attract moisture while also helping the skin retain it.

The Hya10+ Complex supports surface hydration and visible plumpness. Ceramides, phospholipids and squalane help reinforce the skin’s lipid environment, while cupuaçu and shea butters soften and protect against moisture loss. A multi-peptide complex addresses the appearance of wrinkles, elasticity and firmness.

• Hya10+ Complex: Ten forms of hyaluronic acid and hyaluronic acid derivatives support hydration, visible plumpness and skin comfort.
• Multi-Peptide Complex: Includes Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, SH-Oligopeptide-1, SH-Oligopeptide-2, Acetyl Octapeptide-3 and Palmitoyl Pentapeptide-4.
• Ceramides EOP and NP: Help replenish barrier-associated lipids and reduce moisture loss.
• Cupuaçu Butter: Provides rich emollience and helps soften dry, rough or depleted skin.
• Shea Butter: Helps seal in moisture and maintain lasting comfort.
• Kukui Seed Oil: Supplies conditioning fatty acids that support softness and flexibility.
• Squalane: Replenishes the skin with lightweight, compatible emollience.
• Galactomyces Ferment Filtrate: Helps hydrate, condition and support a more luminous-looking complexion.
• Beta-Glucan: Supports hydration while helping comfort dry-feeling skin.
• Antioxidant Extracts: Green tea, grape seed, mulberry and bilberry extracts support the skin against visible environmental stress.

How to Use

Use morning and evening after cleansing, toning and applying serum.

Apply a small amount to the face, neck and décolleté. Massage using gentle upward and outward motions until absorbed.

Pay particular attention to areas that feel dry or appear crepey, including the sides of the neck, upper chest and around the jawline. Avoid vigorous rubbing or pulling.

In the morning, finish with broad-spectrum sunscreen. In the evening, use as the final step unless applying a facial oil or another occlusive product.

If the cream feels too rich for the entire face, use a lighter moisturizer through oilier areas and reserve 24 Hr. Age Defying Cream for the cheeks, neck and décolleté.

Loshen & Crem’s Recommendation

This is one of our bestselling Le Mieux products because it answers a very common need: skin that requires substantial moisture but does not want to feel coated in a heavy, greasy balm.

It is especially beautiful for mature skin, Edmonton winters, dry climates, travel and periods when the complexion suddenly feels tighter or less resilient. You do not need to wait until skin is considered “mature” to use it—persistent dryness and barrier depletion matter more than age.

Pair it with TGF-β Booster when dehydration, visible firmness and fine lines are the priorities. Apply the serum first, allow it to absorb and seal it in with the cream.

A small amount is generally enough. Applying an excessively thick layer does not guarantee longer hydration and may feel heavy beneath sunscreen or makeup.

The current published ingredient list does not include fragrance or parfum. However, the formula contains multiple botanical extracts, cupuaçu butter, shea butter and kukui seed oil. Sensitive skin and clients with nut allergies should patch test and review the current packaging carefully.

Complete the Le Mieux Age-Supportive Routine

1. Cleanse: Peptide Foam Cleanser
2. Prepare: Mist with Iso-Cell Recovery Solution
3. Treat: Apply TGF-β Booster to the face, neck and décolleté
4. Moisturize: Seal in hydration with 24 Hr. Age Defying Cream
5. Replenish: Use Bio Cell+ Mask when an additional hydration boost is desired
6. Protect: Apply broad-spectrum sunscreen every morning

When using retinol or exfoliating acids, apply them according to their directions and follow with 24 Hr. Age Defying Cream. If the skin is persistently burning, peeling or unusually sensitive, pause strong actives rather than expecting moisturizer to compensate for overuse.

24 Hr. Age Defying Cream or Bio Cell Rejuvenating Cream?

Both moisturizers support hydration and visible firmness, but they differ in richness.

• Choose 24 Hr. Age Defying Cream for dry, mature, weathered or crepey-looking skin that needs richer, longer-lasting moisture and barrier support.
• Choose Bio Cell Rejuvenating Cream for normal to dry skin seeking a lighter, silkier moisturizer with peptides, ceramides and a dewy finish.
• Choose Hyaluronic Shea Mask for an intensive overnight treatment or concentrated care for very dry and rough-feeling areas.
• Choose TGF-β Booster as a serum beneath either moisturizer when dehydration and early visible signs of aging are the primary concerns.

If Bio Cell Rejuvenating Cream feels too light by the end of the day, 24 Hr. Age Defying Cream is likely the better choice. If 24 Hr. feels too rich beneath makeup, use Bio Cell Rejuvenating Cream during the day and reserve 24 Hr. for evening.

What Does 24-Hour Hydration Mean?

Le Mieux describes this formula as providing hydration for up to 24 hours. This refers to the cream’s combination of water-binding humectants and moisture-retaining lipids—not a requirement to apply it only once daily.

Hyaluronic acid attracts and holds water at the skin’s surface. Ceramides, phospholipids and squalane support the skin’s lipid environment, while cupuaçu butter, shea butter and kukui seed oil soften the skin and help slow moisture loss.

How long the skin remains comfortable depends on climate, cleansing habits, barrier condition, product amount and individual skin type. Very dry skin may still benefit from morning and evening application.

Why Mature Skin Often Needs More Than Hyaluronic Acid

Hyaluronic acid can help the skin appear plumper and more hydrated, but humectants alone may not be enough for dry or mature skin—particularly in cold, low-humidity climates.

As the skin becomes drier, it may also need emollients and barrier-associated lipids to maintain softness and reduce water loss. This is why 24 Hr. Age Defying Cream pairs its Hya10+ Complex with ceramides, phospholipids, squalane, botanical oils and rich plant butters.

The result is a more complete moisturizing system: humectants attract water, emollients soften rough surface cells and lipids help retain moisture.

Ingredients

• Hya10+ Complex: Ten forms and derivatives of hyaluronic acid support hydration and visible plumpness.
• Galactomyces Ferment Filtrate: Helps condition, hydrate and promote a more luminous-looking complexion.
• Palmitoyl Tripeptide-5: Supports the appearance of firmness and elasticity.
• Acetyl Hexapeptide-8: Helps soften the appearance of expression-related fine lines.
• SH-Oligopeptide-1 and SH-Oligopeptide-2: Lab-produced cosmetic peptides used to support smoother and more resilient-looking skin.
• Acetyl Octapeptide-3: Helps improve the appearance of expression-related wrinkles.
• Palmitoyl Pentapeptide-4: Supports a smoother and more refined-looking complexion.
• Dipalmitoyl Hydroxyproline: An amino-acid derivative that helps condition and support a firmer-looking surface.
• Ceramides EOP and NP: Help maintain the skin barrier and reduce moisture loss.
• Cupuaçu Butter: Deeply conditions dry and rough-feeling skin.
• Shea Butter: Helps seal in moisture and improve softness.
• Kukui Seed Oil: Replenishes skin with conditioning fatty acids.
• Jojoba Oil: Provides lightweight nourishment and supports suppleness.
• Squalane: Softens and helps reduce dry, tight sensations.
• Beta-Glucan: Helps hydrate and comfort moisture-depleted skin.
• Green Tea, Grape Seed, Mulberry and Bilberry Extracts: Provide antioxidant and conditioning benefits.
• Vitamin E and Tocotrienols: Support antioxidant protection and skin softness.

Full Ingredient List:

Galactomyces Ferment Filtrate, Sodium Hyaluronate, Oryza Sativa (Rice) Bran Water, Hyaluronic Acid, Zinc Hydrolyzed Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Sodium Hyaluronate Dimethylsilanol, Sodium Hyaluronate Crosspolymer, C12-13 Alkyl Glyceryl Hydrolyzed Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Ascorbyl Propyl Hyaluronate, Palmitoyl Tripeptide-5, Theobroma Grandiflorum Seed Butter, Simmondsia Chinensis (Jojoba) Seed Oil, Squalane, Pyrus Malus (Apple) Fruit Water, Phospholipids, Acetyl Hexapeptide-8, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Acetyl Glutamine, Acetyl Octapeptide-3, DNA, Sodium Carboxymethyl Beta-Glucan, Dipalmitoyl Hydroxyproline, Ceramide EOP, Ceramide NP, Palmitoyl Pentapeptide-4, Vitis Vinifera (Grape) Seed Oil, Butyrospermum Parkii (Shea) Butter, Aleurites Moluccana Seed Oil, Oryza Sativa (Rice) Bran Oil, Enteromorpha Compressa Extract, Morus Alba Root Extract, Saccharomyces Lysate Extract, Tocotrienols, Camellia Sinensis Extract, Vitis Vinifera (Grape) Seed Extract, Vaccinium Myrtillus Seed Extract, Sphingomonas Ferment Extract, Tocopherol, Caprylyl Glycol, Ethylhexylglycerin, Undecylenoyl Glycine, Capryloyl Glycine.

Ingredient lists may change. Always refer to the product packaging for the most current ingredient list, particularly if you have allergies or sensitivities. Contact info@loshen.ca if you need help reviewing the formula before purchasing.

Frequently Asked Questions

Why is 24 Hr. Age Defying Cream a Loshen & Crem bestseller?

It provides substantial moisture and barrier support without the excessively heavy finish often associated with rich creams. Clients particularly appreciate it for dryness, mature skin and crepey-looking texture across the neck.

What skin types is it best for?

It is best suited to dry, very dry and mature skin. Normal skin may also enjoy it during winter, in dry climates or as an evening moisturizer.

Is it suitable for combination or oily skin?

Combination skin may prefer it at night or only on dry areas. Oily or congestion-prone skin may find the blend of butters and oils richer than necessary.

Does it really hydrate for 24 hours?

Le Mieux states that the formula provides intense hydration for up to 24 hours. Individual results depend on skin type, climate, cleansing habits and barrier condition. It may still be applied morning and evening.

Does it contain ten forms of hyaluronic acid?

Yes. The current ingredient list names ten forms and derivatives within the Hya10+ Complex.

Do ten forms hydrate ten separate layers of skin?

That should not be assumed. The different forms vary in molecular structure, skin affinity and film-forming properties, but the finished formula matters more than assigning each one to a particular layer.

Can it be used morning and night?

Yes. Apply after serum in the morning and evening. Always finish the morning routine with broad-spectrum sunscreen.

Can I use it on my neck and décolleté?

Yes. It is particularly well suited to dryness and crepey-looking texture across the neck and upper chest.

Will it remove wrinkles or tighten crepey skin?

No moisturizer can permanently tighten skin or eliminate wrinkles. Hydration can temporarily plump the surface, while peptides, lipids and emollients support a smoother and firmer-looking appearance with consistent use.

Can I use it with TGF-β Booster?

Yes. Apply TGF-β Booster first and follow with 24 Hr. Age Defying Cream to seal in hydration.

Can I use it with retinol or exfoliating acids?

Yes, provided the skin tolerates the active treatment. Apply the active according to its directions, then follow with the cream. Reduce active-product frequency if persistent irritation develops.

Can it be worn under makeup?

Yes. Apply a thin, even layer and allow it to absorb before sunscreen and makeup. Using too much may feel heavy or contribute to pilling.

Is it fragrance-free?

No fragrance or parfum is listed in the current published ingredient list. Individual sensitivity to botanical ingredients can still vary.

Is it suitable for sensitive skin?

The formula contains barrier-supporting ingredients, but it is also complex and includes multiple botanical extracts, oils and butters. Sensitive skin should patch test before regular use.

Can I use it if I have a nut allergy?

The formula contains shea butter and kukui seed oil. Those with nut allergies should consult their healthcare provider and contact Loshen & Crem for help reviewing the current packaging before use.

Is it non-comedogenic?

The official product page does not identify it as non-comedogenic. Because the formula contains rich butters and oils, congestion-prone skin should introduce it gradually.

What are SH-Oligopeptide-1 and SH-Oligopeptide-2?

They are lab-produced cosmetic peptides commonly used in age-supportive formulas. Their inclusion does not make the cream a medical treatment, and visible results depend on the complete formulation and consistent use.

Is the cream vegan?

The current ingredient list includes DNA and does not identify the origin of every ingredient. Vegan status should not be assumed without confirmation from Le Mieux.

Can it be used during pregnancy or breastfeeding?

The published formula does not list retinoids or exfoliating acids. However, pregnancy and breastfeeding considerations are individual, so consult your physician or qualified healthcare provider before introducing a new product.

Does it contain sunscreen?

No. Apply a separate broad-spectrum sunscreen every morning.