Your routine
CircadiaCyto-Comm Serum
Why it fits
Cyto-Comm Serum first for its firming benefits, then Nighttime Repair Plus on top: a lovely evening routine for mature skin.

Skincare Boutique & Facial Institute
Skincare Boutique & Facial Institute
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Explore La Crem rewardsMature skin, used to retinoids
A higher-strength vitamin A night cream for mature skin and for those already comfortable with retinoids. Peptides, ceramides and antioxidants help skin look smoother, firmer and more radiant by morning.
Discover the formula & ingredientsPickup in Edmonton
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5238 Windermere Boulevard
Edmonton AB T6W 0L9
Canada
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Circadia
Your ritual begins with the right choice.
$160.00 CAD
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The skincare focus
A higher-strength vitamin A night cream for mature skin and for those already comfortable with retinoids. Peptides, ceramides and antioxidants help skin look smoother, firmer and more radiant by morning.
Explore our ingredient glossaryCircadia
The ingredients behind this formula—and what they bring to your skin.
Retinyl Acetate (Vitamin A)
In a higher concentration than the original formula, encourages skin renewal for a smoother, more even look.
Tetrahexyldecyl Ascorbate (Vitamin C)
An oil-soluble form of vitamin C that adds antioxidant support.
Niacinamide (Vitamin B3)
Helps support the skin barrier and even the look of skin tone.
Ingredient imagery is illustrative. Explore the full ingredient list below.
Made to work together
If you have never used a retinoid, begin with Nighttime Repair. Keep the rest of the evening simple, and book a consultation if you would like guidance on where to start.
Your routine
Cyto-Comm Serum first for its firming benefits, then Nighttime Repair Plus on top: a lovely evening routine for mature skin.
Your routine
The last step of your morning routine, over serum, eye cream and moisturizer.
Worth knowing
A closer look at your skin, your routine and what goes into the formula.
Circadia Nighttime Repair Plus is a night cream with a higher concentration of vitamin A than the original Nighttime Repair. It is designed for mature skin and for those already comfortable with retinoids.
Peptides, ceramides and antioxidants work alongside vitamin A to encourage skin renewal, support the skin barrier and help skin look smoother, firmer and more radiant by morning.
If you have never used a retinoid, start with Nighttime Repair and move up once your skin is comfortable.
This is where a vitamin A routine goes once skin is ready for more. It keeps the same thoughtful support as the original, ceramides, niacinamide and peptides, with more vitamin A to work on visible signs of time and sun. We would always rather you build up to it than start here.
Mature skin, used to retinoids
Moving up from Nighttime Repair? Start Plus a few evenings a week and build up, just as you did the first time.
Aqua/Water, Caprylic/Capric Triglyceride, Glycerin, Bis-PEG/PPG-16/16 PEG/PPG-16/16 Dimethicone, Ethylhexyl Methoxycrylene, Cetyl Ethylhexanoate, Niacinamide, Palmitoyl Glycine, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Isohexadecane, Tetrahexyldecyl Ascorbate, Triethyl Citrate, Sodium Lauroyl Lactylate, Ergothioneine, Asiaticoside, Madecassic Acid, Sorbitan Oleate, Pentylene Glycol, Retinyl Acetate, Asiatic Acid, Palmitoyl Tripeptide-38, Tetrasodium EDTA, Arachis Hypogaea (Peanut/Arachide/Cacahuete) Oil, Palmitic Acid, Vanilla Planifolia Fruit Extract, Hydroxypropyl Cyclodextrin, Lactic Acid, Isopropyl Palmitate, Ceramide NP, Phytosphingosine, Ceramide AP, Ceramide EOP, Cholesterol, Xanthan Gum, Ethylhexylglycerin, Rosmarinus Officinalis Leaf Extract, Palmitoyl Tetrapeptide-7, Tocopherol, Chrysin, Carbomer, Polysorbate 80, Hexylene Glycol, Caprylyl Glycol, Phenoxyethanol, Sodium Hydroxide.
Mature skin, skin with visible sun damage, and anyone already comfortable with retinoids.
We suggest starting with Nighttime Repair and moving up once your skin is comfortable.
In the evening. If you are not yet used to vitamin A, start with a few evenings per week and build up gradually.
Yes. Wear sunscreen every morning while using this product.
We like Cyto-Comm Serum first, then Nighttime Repair Plus on top.
For delivery and return information, view our policy.
A higher-strength vitamin A night cream for mature skin
Circadia Nighttime Repair Plus is a night cream with a higher concentration of vitamin A than the original Nighttime Repair, designed for mature skin and for those already comfortable with retinoids. Peptides, ceramides and antioxidants work alongside vitamin A to encourage skin renewal, support the skin barrier and help skin look smoother, firmer and more radiant by morning.
In the evening, after cleanser and serum, dispense a pea-sized amount onto fingertips and apply to face and neck. Avoid contact with eyes. If you are not yet used to vitamin A, start with a few evenings per week and build up gradually. Wear sunscreen every morning while using this product.
In the evening, apply Cyto-Comm Serum first for its firming benefits, then layer Nighttime Repair Plus on top. It is a lovely routine for mature skin or skin with visible sun damage. If you have never used a retinoid, we suggest starting with Nighttime Repair and moving up once your skin is comfortable. Always follow with Circa-Shield Mineral Sunscreen SPF 30 in the morning, and book a consultation if you would like guidance on where to start.
Aqua/Water, Caprylic/Capric Triglyceride, Glycerin, Bis-PEG/PPG-16/16 PEG/PPG-16/16 Dimethicone, Ethylhexyl Methoxycrylene, Cetyl Ethylhexanoate, Niacinamide, Palmitoyl Glycine, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Isohexadecane, Tetrahexyldecyl Ascorbate, Triethyl Citrate, Sodium Lauroyl Lactylate, Ergothioneine, Asiaticoside, Madecassic Acid, Sorbitan Oleate, Pentylene Glycol, Retinyl Acetate, Asiatic Acid, Palmitoyl Tripeptide-38, Tetrasodium EDTA, Arachis Hypogaea (Peanut/Arachide/Cacahuete) Oil, Palmitic Acid, Vanilla Planifolia Fruit Extract, Hydroxypropyl Cyclodextrin, Lactic Acid, Isopropyl Palmitate, Ceramide NP, Phytosphingosine, Ceramide AP, Ceramide EOP, Cholesterol, Xanthan Gum, Ethylhexylglycerin, Rosmarinus Officinalis Leaf Extract, Palmitoyl Tetrapeptide-7, Tocopherol, Chrysin, Carbomer, Polysorbate 80, Hexylene Glycol, Caprylyl Glycol, Phenoxyethanol, Sodium Hydroxide.
The care behind your order
A few helpful details, before your next delivery.
Track your order01 · Across Canada
$149+Free Regular shipping
$249+Free Priority shipping
CAD · After discounts, before taxes and shipping. Conditions and product exclusions apply.
Canada & U.S. delivery details02 · Close to home
Choose pickup at checkout when available. We’ll let you know when your order is ready.
Speak with our boutique03 · Care you can count on
Request an eligible return within 30 days. Items must be unopened, unused and in their original packaging. Final-sale exclusions apply.
Returns & order support
In a higher concentration than the original formula, encourages skin renewal for a smoother, more even look.
An oil-soluble form of vitamin C that adds antioxidant support.
Helps support the skin barrier and even the look of skin tone.
Skin-identical lipids that help reinforce the barrier.
Peptides that help smooth the look of lines and support the look of firmness.
Curious about your ingredients?
Explore La Matière
Expert guidance. A considered routine.
Beautiful formulas are only part of the story. Knowing what belongs in your routine makes all the difference.
Talk through your skin, the products you already use and the questions on your mind with one of our facialists.
Book a consultation Just a product question? Ask us.The care behind your care
From your first question to your next replenishment, there’s a real person here to help.
You don’t need to start over. Bring us your current routine and we’ll help you understand where a new formula fits.
Ask our teamTake our skin questionnaire for a thoughtful starting point, then speak with us if you’d like to explore your recommendations.
Find your starting pointA question about how to use it? Unsure about your next step? You’re welcome to come back to our team for guidance.
We’re here to helpFrom our Edmonton boutique
Discover Circadia Nighttime Repair Plus at Loshen & Crem, a skin-health boutique and facial studio in Edmonton, Alberta. Explore the Circadia collection online across Canada, or speak with our facialists about how this formula fits into the products you already use.
Care, to keep.
The guidance you’ll want when you get home: how to use it, what to expect and when to check in. Your reminder, with your team still in reach.
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