We should never forget that Melasma prevails among people with dark skin. While approximately only an 8,8% of Latin women are affected of Melasma, a 40% of population suffer this affection in South Asia. It can be caused by the presence of melanocytes biologically more active in the affected skin instead of a simple increase of melanocytes. The incidence of melasma among the same members of a family suggests that there is also a genetic susceptibility. Sun exposure exacerbates this alteration probably because the positive regulation induced by ultraviolet radiation on melanocyte-stimulating cytokines.