


Pavise Extracellular Matrix Restore
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Advanced Post-Procedure Recovery & Regeneration
An innovative, bioactive second skin designed to amplify the impact and outcomes of in-office treatments. Extracellular Matrix Restore acts as a regenerative elixir, directing extracellular matrix (ECM) recovery while modulating inflammation. Powered by Pavise’s proprietary DiamondCore® biotechnology, this anhydrous, preservative-free treatment supports healthy cell activity, rebuilds epidermal density, and accelerates visible healing for compromised skin.
Benefits:
- Accelerates visible skin regeneration and supports ECM renewal
- Improves epidermal density, structure, and barrier resilience
- Calms post-procedure inflammation, pain, and itching
- Defends against oxidative stress and inflammatory free radical damage
- Helps prevent post-inflammatory hyperpigmentation (dark spots)
- Bacteriostatic, fragrance-free, vegan, and formulated for compromised barriers
Clinically-Proven Results:
| Metric | Clinical Improvement |
| Fibroblast Growth & Migration | 198% Increase |
| Epidermal Thickness | 182% Increase |
| Perlecan Expression | 163% Increase |
| Fibromodulin Expression | 108% Increase |
| Collagen Synthesis | 91% Increase |
| Hyaluronic Acid Production | 79% Increase |
| Keratinocyte Proliferation | 32% Increase |
How to Use:
- Apply a generous, even layer to treated skin immediately post-treatment
- Reapply as needed, or strictly as directed by your medical professional
- Use specifically as an extension to in-office clinical procedures
- Ideal for sensitive, reactive, and post-procedure skin with a compromised barrier
Loshen & Crem’s Recommendation:
Ideal as an essential recovery treatment for anyone undergoing intensive clinical procedures like lasers, microneedling, or chemical peels. Especially well-suited for highly sensitive or compromised skin, this elixir acts as a breathable bandage to maximize your treatment investment, ensuring rapid healing and superior long-term results without irritation.
Ingredients:
Key Ingredients:
- DiamondCore®: Proprietary molecule that stimulates fibroblast activity and collagen organization while controlling inflammatory and senescent cell signaling.
- Human Recombinant Collagen III: Often called “baby collagen,” this maintains skin elasticity, density, and a plump, smooth texture.
- Human Recombinant Growth Factors: Signaling proteins that promote cellular communication, fibroblast activation, and rapid skin renewal.
- Signaling Peptides: Messengers that influence cell behavior, stimulating the repair and proliferation of vital ECM scaffolding proteins.
Full Ingredients List:
Petrolatum, Pentaerythrityl Tetraisostearate, Caprylic/Capric Triglyceride, Undecane, Pentylene Glycol, Aluminum Starch Octenylsuccinate, Butylene Glycol, Propanediol, Passiflora Edulis (Passion Fruit) Seed Oil, Colloidal Diamond, Zinc Oxide, sr-(sh-Polypeptide-69 Dipeptide-19), Palmitoyl Hexapeptide-12, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Palmitoyl Dipeptide-10, sh-Polypeptide-10, sh-Polypeptide-1, Dipalmitoyl Hydroxyproline, Madecassoside, Centella Asiatica Extract, Ceramide NP, Panthenyl Triacetate, Palmitic Acid, Tocopherol, 4-t-butylcyclohexanol, Helianthus Annuus (Sunflower) Seed Oil, Tridecane, Triolein, Glyceryl Caprylate, Water (Aqua), Glyceryl Dioleate, Citrus Aurantium Amara (Bitter Orange) Fruit Extract, Propylene Carbonate, Stearalkonium Hectorite, Sodium Chloride, Potassium Phosphate.
Free Express Shipping with orders over $199
Available at our Edmonton Boutique
Ship to Canada only
Pickup currently unavailable at Loshen & Crem

Pavise Extracellular Matrix Restore
30 ml
Loshen & Crem
5238 Windermere Boulevard
Edmonton AB T6W 0L9
Canada
Returns & Refunds
At Loshen & Crem, we understand that sometimes, even the most carefully chosen product might not be "the one."
- Returns: You have 30 days from delivery to return any unopened and unused products in perfect condition—just as they arrived.
- Refunds: If your return reaches us within 30 days of purchase, you’ll have the choice between a refund or store credit (your preference, naturellement). After 30 days, store credit is your only option. Beyond 40 days, refunds and credits are no longer possible.
Final Sale Items
For transparency, certain items are final sale and not eligible for return or exchange:
- Products on sale
- Products marked “Final markdown” on our online store
- Gift cards
- Promotional kits and deluxe samples
- Limited-edition or seasonal item
Shipping Policy
At Loshen & Crem, we take delivering your skincare treasures très seriously. From Canada to the U.S., we’re here to ensure your beauty cabinet is always well-stocked.
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Free Shipping:
- Canada: Complimentary EXPRESS shipping on orders over $199 CAD (after discounts and before taxes).
- United States: Complimentary EXPRESS shipping on orders over $250 USD. We are temporarily pausing USD payments at the moment. Apologies for the inconvenience, and thank you for your understanding!
- During our annual sales, enjoy free EXPEDITED shipping for orders over $250 CAD (or $350 USD).
- For smaller indulgences, shipping is $24.95 CAD within Canada and $30.95 USD to the U.S.
P.S. We ship to P.O. Boxes via Canada Post—but not during strikes. C’est compliqué.
Processing Time:
We aim to dispatch your order within 2 business days, though peak sales and payment verifications may require a touch more patience.
Please note that if you make any changes with the courier after the dispatch, our carrier will charge a $32 fee. In addition, we will have to withdraw the Free Express shipping option from your SkinSkinGlow points account. We appreciate your understanding.
Our processing time starts from the moment your order is successfully submitted and may take up to 2 business days to dispatch your order. However, please be aware that processing and handling time may be extended during peak sale periods. Before we can ship your order, we may need to hold your order for payment verification and confirm your details with your card issuer.
We will do our very best to minimize delays.
Shipping Rates & Delivery Times
Estimated Delivery Times (Canada):
- British Columbia & Alberta: 1–2 business days
- Manitoba & Saskatchewan: 1–2 business days
- Quebec & Ontario: 1–2 business days
- Atlantic Provinces: 1–3 business days
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United States: Delivery times vary by region:
- Zone 1: Eastern States – 3–4 business days
- Zone 2: Central States – 4–5 business days
- Zone 3: Western States – 5 business days
Remote areas may experience longer shipping times.Please Note: Shipping windows are estimates and not guarantees. Delays may occur due to weather, traffic, or additional verification processes.
Shipping Address Details
For a smooth delivery, please provide all relevant information, including buzzer codes, directional suffixes (North, South, etc.), or special instructions.
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Address Changes: Once your package has left our warehouse, address updates cannot be made. If you need to make changes before dispatch, email us at info@loshen.ca with your order details.
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Carrier Fees: Any changes made with the courier after dispatch will incur a $32 CAD fee, and the Free Express Shipping option will be deducted from your La Crème Points account.
Tracking Your Order
All shipments include tracking information, so you can follow your package from our warehouse to your door. A confirmation email with your tracking number will be sent once your order is dispatched.
Damaged or Lost Packages
- Damaged Parcels: If your order arrives damaged, please contact us at info@loshen.ca with photos and details. We’ll work to resolve the issue promptly.
- Lost or Stolen Packages: If your package is marked "delivered" but hasn’t arrived, please contact the carrier directly to file a claim.
Tips to Avoid Lost or Stolen Packages:
- Opt for a signature upon receipt (required for orders over $350 CAD).
- Have your package delivered to your workplace.
- If you’re not home on the expected delivery date, ask a neighbor to receive your package.
Unclaimed Parcels
If your package is returned to us unclaimed, we’ll issue a refund minus a $24.95 CAD return shipping fee.
Free Samples
We believe every order deserves a little extra care! Expect 1–3 complimentary samples selected by our Skincare Specialists to perfectly complement your order.
Loyalty Rewards: La Crem Points
Earn La Crème Points with every purchase and redeem them for future orders. From time to time, we also offer Free Gifts With Purchase (GWP) for select brands, but these are available only while supplies last.
At Loshen & Crem, we aim to deliver excellence at every step of your skincare journey, with care and a touch of elegance. Questions? Don’t hesitate to reach out—we’re always happy to assist!
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